Transporters in Drug Discovery and Development

Written By Yurong Lai
Transporters in Drug Discovery and Development
  • Publsiher : Woodhead Publishing
  • Release : 22 August 2014
  • ISBN : 190881828X
  • Pages : 780 pages
  • Rating : /5 from reviews
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Download or read book entitled Transporters in Drug Discovery and Development by author: Yurong Lai which was release on 22 August 2014 and published by Woodhead Publishing with total page 780 pages . This book available in PDF, EPUB and Kindle Format. Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
  • Author : Yurong Lai
  • Publisher : Woodhead Publishing
  • Release Date : 2014-08-22
  • Total pages : 780
  • ISBN : 190881828X
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Summary : Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant ...

Transporters in Drug Development

Transporters in Drug Development
  • Author : Yuichi Sugiyama,Bente Steffansen
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-09-16
  • Total pages : 317
  • ISBN : 190881828X
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Summary : Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization ...

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development
  • Author : Qing Yan
  • Publisher : Humana
  • Release Date : 2010-04-26
  • Total pages : 365
  • ISBN : 190881828X
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Summary : This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development....

Drug Transporters

Drug Transporters
  • Author : Guofeng You,Marilyn E. Morris
  • Publisher : John Wiley & Sons
  • Release Date : 2014-07-07
  • Total pages : 528
  • ISBN : 190881828X
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Summary : This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical ...

Oral Bioavailability Assessment

Oral Bioavailability Assessment
  • Author : Ayman F. El-Kattan
  • Publisher : John Wiley & Sons
  • Release Date : 2017-05-15
  • Total pages : 448
  • ISBN : 190881828X
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Summary : Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the ...

Pharmacogenomics of Human Drug Transporters

Pharmacogenomics of Human Drug Transporters
  • Author : Toshihisa Ishikawa,Richard B. Kim,Jörg König
  • Publisher : John Wiley & Sons
  • Release Date : 2013-03-11
  • Total pages : 440
  • ISBN : 190881828X
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Summary : Sets the foundation for safer, more effective drugtherapies With this book as their guide, readers will discover how toapply our current understanding of the pharmacogenomics of drugtransporters to advance their own drug discovery and developmentefforts. In particular, the book explains how new findings in thefield now enable researchers to more ...

Drug Transporters

Drug Transporters
  • Author : Glynis Nicholls,Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-08-16
  • Total pages : 463
  • ISBN : 190881828X
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Summary : Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second ...

Drug Transporters

Drug Transporters
  • Author : Glynis Nicholls,Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-08-17
  • Total pages : 239
  • ISBN : 190881828X
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Summary : Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis ...

Drug Transporters Molecular Characterization and Role in Drug Disposition Third Edition

Drug Transporters  Molecular Characterization and Role in Drug Disposition  Third Edition
  • Author : John Wiley & Sons Canada, Limited
  • Publisher : Unknown
  • Release Date : 2022-07-06
  • Total pages : 600
  • ISBN : 190881828X
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Summary : Unique in the field of pharmaceutical science, this revised 3rd edition takes into account that knowledge in transporters as drug targets for diseases has expanded. Since publication of the second edition, there have been significant advances in the field: in-depth understanding of membrane transporters in pediatric pharmacotherapy, new insights into ...

Membrane Transporters and Channels as Targets for Drugs

Membrane Transporters and Channels as Targets for Drugs
  • Author : Graça Soveral,Cesare Indiveri
  • Publisher : Frontiers Media SA
  • Release Date : 2020-01-03
  • Total pages : 212
  • ISBN : 190881828X
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Summary : Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. ...

Chemical Biology

Chemical Biology
  • Author : Natanya Civjan
  • Publisher : John Wiley & Sons
  • Release Date : 2012-08-07
  • Total pages : 524
  • ISBN : 190881828X
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Summary : An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used ...

ADME Enabling Technologies in Drug Design and Development

ADME Enabling Technologies in Drug Design and Development
  • Author : Donglu Zhang,Sekhar Surapaneni
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-13
  • Total pages : 800
  • ISBN : 190881828X
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Summary : A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME). ADME-Enabling Technologies in Drug ...

Transporters and Drug Metabolizing Enzymes in Drug Toxicity

Transporters and Drug Metabolizing Enzymes in Drug Toxicity
  • Author : Albert P. Li
  • Publisher : Wiley
  • Release Date : 2021-04-27
  • Total pages : 352
  • ISBN : 190881828X
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Summary : Accurate assessment of human drug toxicity is a major challenge in the pharmaceutical industry. Drug metabolism and toxicology are two scientific disciplines that traditionally have been considered independently. For instance, in drug development, drug candidates are evaluated for properties in these two disciplines in different departments. It is now becoming ...

Evaluation of Drug Candidates for Preclinical Development

Evaluation of Drug Candidates for Preclinical Development
  • Author : Chao Han,Charles B. Davis,Binghe Wang
  • Publisher : John Wiley & Sons
  • Release Date : 2010-01-06
  • Total pages : 304
  • ISBN : 190881828X
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Summary : Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early ...

ABC Transporters and Multidrug Resistance

ABC Transporters and Multidrug Resistance
  • Author : Ahcène Boumendjel,Jean Boutonnat,Jacques Robert
  • Publisher : John Wiley & Sons
  • Release Date : 2009-06-17
  • Total pages : 480
  • ISBN : 190881828X
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Summary : A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to ...