Trace Amines and Neurological Disorders

Written By Tahira Farooqui
Trace Amines and Neurological Disorders
  • Publsiher : Academic Press
  • Release : 08 August 2016
  • ISBN : 9780128036037
  • Pages : 432 pages
  • Rating : /5 from reviews
GET THIS BOOKTrace Amines and Neurological Disorders


Download or read book entitled Trace Amines and Neurological Disorders by author: Tahira Farooqui which was release on 08 August 2016 and published by Academic Press with total page 432 pages . This book available in PDF, EPUB and Kindle Format. "Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors" explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disordersEdited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage availableProvides cutting-edge research on trace amines-mediated signaling in vertebrate model systems"

Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui
  • Publisher : Academic Press
  • Release Date : 2016-08-08
  • Total pages : 432
  • ISBN : 9780128036037
GET BOOK

Summary : "Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors" explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating ...

Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2016-07-12
  • Total pages : 432
  • ISBN : 9780128036037
GET BOOK

Summary : Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating ...

Neuropsychopharmacology of the Trace Amines

Neuropsychopharmacology of the Trace Amines
  • Author : Alan A. Boulton,Peter R. Bieck,L. Maitre,P. Riederer
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 510
  • ISBN : 9780128036037
GET BOOK

Summary : A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed ...

Trace Amines and the Brain

Trace Amines and the Brain
  • Author : Earl Usdin,Merton Sandler,American College of Neuropsychopharmacology
  • Publisher : Marcel Dekker
  • Release Date : 1976
  • Total pages : 301
  • ISBN : 9780128036037
GET BOOK

Summary : Read online Trace Amines and the Brain written by Earl Usdin,Merton Sandler,American College of Neuropsychopharmacology, published by Marcel Dekker which was released on 1976. Download full Trace Amines and the Brain Books now! Available in PDF, ePub and Kindle....

Trace Amine Associated Receptor 1 TAAR1 a Novel Astrocyte Receptor for METH mediated Neurotoxicity

Trace Amine Associated Receptor 1  TAAR1   a Novel Astrocyte Receptor for METH mediated Neurotoxicity
  • Author : Irma E. Cisneros
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 152
  • ISBN : 9780128036037
GET BOOK

Summary : This dissertation explores the role of astrocyte trace amine associated receptor 1 (TAAR1), a novel G-protein coupled receptor (GPCR), in modulating the effects of methamphetamine (METH) on astrocyte-mediated excitotoxicity, thereby exacerbating HIV-associated neurocognitive disorders (HAND). The rising pandemic of methamphetamine (METH) abuse has multiple effects and interactions with HIV-1 in infected ...

Neurobiology of the Trace Amines

Neurobiology of the Trace Amines
  • Author : Alan A. Boulton,Glen B. Baker,William G. Dewhurst,Merton Sandler
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-12
  • Total pages : 598
  • ISBN : 9780128036037
GET BOOK

Summary : Many of the trace amines-more correctly called biogenic amines have been known for decades, but because of their tiny concentra tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. ...

Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2020-09-07
  • Total pages : 400
  • ISBN : 9780128036037
GET BOOK

Summary : Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also ...

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2020-03-20
  • Total pages : 498
  • ISBN : 9780128036037
GET BOOK

Summary : Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help ...

11 Loss of function Mutations in the Trace Amine associated Receptor 1 TAAR1 Among Patients with Major Mental Disorders

11   Loss of function Mutations in the Trace Amine associated Receptor 1  TAAR1  Among Patients with Major Mental Disorders
  • Author : Grazia Rutigliano
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 9780128036037
GET BOOK

Summary : Objectives. To identify and functionally characterize variants in the trace amine associated receptor 1 (TAAR1) in a cohort of patients suffering from major mental disorders.Background and aims. The G protein-coupled receptor (GPCR) TAAR1 is widely expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic ...

Addiction Medicine E Book

Addiction Medicine E Book
  • Author : Bankole Johnson
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-12-12
  • Total pages : 788
  • ISBN : 9780128036037
GET BOOK

Summary : Integrating scientific knowledge with today’s most effective treatment options, Addiction Medicine: Science and Practice, 2nd Edition, provides a wealth of information on addictions to substances and behavioral addictions. It discusses the concrete research on how the brain and body are affected by addictions, improving your understanding of how patients ...

Ischemic and Traumatic Brain and Spinal Cord Injuries

Ischemic and Traumatic Brain and Spinal Cord Injuries
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2018-03-21
  • Total pages : 484
  • ISBN : 9780128036037
GET BOOK

Summary : Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs ...

Encyclopedia of Neuroscience Volume 1

Encyclopedia of Neuroscience  Volume 1
  • Author : Larry R. Squire
  • Publisher : Academic Press
  • Release Date : 2009-06-12
  • Total pages : 12505
  • ISBN : 9780128036037
GET BOOK

Summary : The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before ...

Research Methods in Neurochemistry

Research Methods in Neurochemistry
  • Author : Neville Marks
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 442
  • ISBN : 9780128036037
GET BOOK

Summary : The fourth volume of Research Methods in Neurochemistry includes chapters on different aspects of topics touched on in previous volumes and develops a number of new themes as well. The bias, though not entirely intended, is directed toward studies of macromolecules, both at the meta bolic level in relation to ...

Mechanisms of Neurological Disease

Mechanisms of Neurological Disease
  • Author : Anthony J. Lewis
  • Publisher : Little, Brown Medical Division
  • Release Date : 1976
  • Total pages : 540
  • ISBN : 9780128036037
GET BOOK

Summary : Read online Mechanisms of Neurological Disease written by Anthony J. Lewis, published by Little, Brown Medical Division which was released on 1976. Download full Mechanisms of Neurological Disease Books now! Available in PDF, ePub and Kindle....

Thyroid Hormone and Metabolites Central Versus Peripheral Effects

Thyroid Hormone and Metabolites  Central Versus Peripheral Effects
  • Author : Grazia Chiellini,Federica Cioffi,Rosalba Senese,Pieter de Lange
  • Publisher : Frontiers Media SA
  • Release Date : 2019-07-19
  • Total pages : 212
  • ISBN : 9780128036037
GET BOOK

Summary : Read online Thyroid Hormone and Metabolites Central Versus Peripheral Effects written by Grazia Chiellini,Federica Cioffi,Rosalba Senese,Pieter de Lange, published by Frontiers Media SA which was released on 2019-07-19. Download full Thyroid Hormone and Metabolites Central Versus Peripheral Effects Books now! Available in PDF, ePub and Kindle....