Third Generation EGFR Inhibitors

Written By Harun M. Patel
Third Generation EGFR Inhibitors
  • Publsiher : Elsevier
  • Release : 15 March 2019
  • ISBN : 9780081026618
  • Pages : 290 pages
  • Rating : /5 from reviews
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Download or read book entitled Third Generation EGFR Inhibitors by author: Harun M. Patel which was release on 15 March 2019 and published by Elsevier with total page 290 pages . This book available in PDF, EPUB and Kindle Format. EGFR inhibitors are useful tools in cancer therapeutics, but resistance to the first generations have significantly increased, meaning a new generation of improved inhibitors are needed with better efficacy and lower toxicity. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. Mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are then explored before a discussion of potential future trends. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems is a guide for medicinal chemists, drug developer, and researchers investigating cancer therapeutics, supporting them in the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and looks at how they may be able to overcome the constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors and reviews both their design strategies and typical anticancer activity

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,S. J. Surana
  • Publisher : Elsevier
  • Release Date : 2019-03-15
  • Total pages : 290
  • ISBN : 9780081026618
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Summary : EGFR inhibitors are useful tools in cancer therapeutics, but resistance to the first generations have significantly increased, meaning a new generation of improved inhibitors are needed with better efficacy and lower toxicity. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of ...

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,Sanjay J. Surana
  • Publisher : Elsevier
  • Release Date : 2018-11-27
  • Total pages : 208
  • ISBN : 9780081026618
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Summary : Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation ...

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma
  • Author : Caroline Amalia Nebhan
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 145
  • ISBN : 9780081026618
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Summary : Read online Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma written by Caroline Amalia Nebhan, published by which was released on 2014. Download full Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma Books now! Available in PDF, ePub and Kindle....

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  • Publisher : Bentham Science Publishers
  • Release Date : 2020-09-01
  • Total pages : 163
  • ISBN : 9780081026618
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Summary : Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug ...

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC
  • Author : Anthony Faber
  • Publisher : Academic Press
  • Release Date : 2021-03-15
  • Total pages : 250
  • ISBN : 9780081026618
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Summary : Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is ...

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Clinical Applications of Circulating Tumor DNA Analysis
  • Author : Jacob John Chabon
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 9780081026618
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Summary : Circulating tumor DNA (ctDNA) represents an exquisitely specific biomarker due to the fact that tumors harbor somatic mutations that are not present in other cell-types in the body. We begin with a review of the existing methodologies and applications of ctDNA, highlighting studies that illustrate the diverse clinical utility of ...

Nature

Nature
  • Author : Sir Norman Lockyer
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 9780081026618
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Summary : Read online Nature written by Sir Norman Lockyer, published by which was released on 2008. Download full Nature Books now! Available in PDF, ePub and Kindle....

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  • Author : Goetz Kloecker,Mostafa Fraig,Susanne M. Arnold,Cesar A. Perez
  • Publisher : McGraw Hill Professional
  • Release Date : 2021-01-08
  • Total pages : 336
  • ISBN : 9780081026618
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Summary : An essential guide to the treatment and management of lung cancer Lung cancer remains the leading cause of cancer deaths worldwide, attributed mostly to environmental and behavioral factors. However, a diagnosis of lung cancer no longer means inevitable death. The new standards of care and a greater understanding of the ...

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  • Publisher : McGraw Hill Professional
  • Release Date : 2020-07-03
  • Total pages : 2512
  • ISBN : 9780081026618
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Summary : Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 25+ additional chapters available online! The classic guide to driving optimal patient outcomes using evidence-based medication therapies—updated with the latest advances and guidelines ...

The Basic Science of Oncology Sixth Edition

The Basic Science of Oncology  Sixth Edition
  • Author : Lea Harrington,Robert E. Bristow,Ian F. Tannock,Richard Hill
  • Publisher : McGraw Hill Professional
  • Release Date : 2021-01-08
  • Total pages : 608
  • ISBN : 9780081026618
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Summary : Complete coverage of the basis of cancer and molecular biology – from globally recognized experts The Basic Science of Oncology is an accessible and thorough introduction to cancer causation, cancer biology, and the biology underlying cancer treatment. You’ll find everything you need to know about the latest critical thinking in ...

Goodman and Gilman s The Pharmacological Basis of Therapeutics 13th Edition

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  • Author : Laurence Brunton,Bjorn Knollman,Randa Hilal-Dandan
  • Publisher : McGraw Hill Professional
  • Release Date : 2017-10-26
  • Total pages : 1808
  • ISBN : 9780081026618
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Summary : The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody’s Core Title for 2019! Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology ...

Anticancer Research

Anticancer Research
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 9780081026618
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Summary : Read online Anticancer Research written by , published by which was released on 2007. Download full Anticancer Research Books now! Available in PDF, ePub and Kindle....

Reviews on Endocrine related Cancer

Reviews on Endocrine related Cancer
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1993
  • Total pages : 212
  • ISBN : 9780081026618
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Summary : Read online Reviews on Endocrine related Cancer written by , published by which was released on 1993. Download full Reviews on Endocrine related Cancer Books now! Available in PDF, ePub and Kindle....

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The CenterWatch Directory of Drugs in Clinical Trials
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2000
  • Total pages : 656
  • ISBN : 9780081026618
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Summary : Read online The CenterWatch Directory of Drugs in Clinical Trials written by , published by which was released on 2000. Download full The CenterWatch Directory of Drugs in Clinical Trials Books now! Available in PDF, ePub and Kindle....

CURRENT Medical Diagnosis and Treatment 2021

CURRENT Medical Diagnosis and Treatment 2021
  • Author : Maxine A. Papadakis,Stephen J. McPhee,Michael W. Rabow
  • Publisher : McGraw Hill Professional
  • Release Date : 2020-09-09
  • Total pages : 1920
  • ISBN : 9780081026618
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Summary : The 60th anniversary edition of the most popular, relied-upon guide to internal medicine For 60 years, CURRENT Medical Diagnosis and Treatment—the flagship volume of the renowned Lange medical series—has been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Covering the ...