Therapeutic Applications of Quadruplex Nucleic Acids

Written By Cancer Research Campaign Biomolecular Structure Unit Stephen Neidle
Therapeutic Applications of Quadruplex Nucleic Acids
  • Publsiher : Academic Press
  • Release : 02 September 2016
  • ISBN : 9780128103722
  • Pages : 208 pages
  • Rating : /5 from reviews
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Download or read book entitled Therapeutic Applications of Quadruplex Nucleic Acids by author: Cancer Research Campaign Biomolecular Structure Unit Stephen Neidle which was release on 02 September 2016 and published by Academic Press with total page 208 pages . This book available in PDF, EPUB and Kindle Format. The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligandsand the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas. "

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Cancer Research Campaign Biomolecular Structure Unit Stephen Neidle,Stephen Neidle
  • Publisher : Academic Press
  • Release Date : 2016-09-02
  • Total pages : 208
  • ISBN : 9780128103722
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Summary : The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ...

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release Date : 2011
  • Total pages : 196
  • ISBN : 9780128103722
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Summary : New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in ...

G Quadruplex Nucleic Acids

G Quadruplex Nucleic Acids
  • Author : Danzhou Yang,Clement Lin
  • Publisher : Humana
  • Release Date : 2019-08-24
  • Total pages : 437
  • ISBN : 9780128103722
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Summary : This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods ...

Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids
  • Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-10
  • Total pages : 448
  • ISBN : 9780128103722
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Summary : Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and ...

G Quadruplex Nucleic Acids

G Quadruplex Nucleic Acids
  • Author : Danzhou Yang
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 437
  • ISBN : 9780128103722
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Summary : Read online G Quadruplex Nucleic Acids written by Danzhou Yang, published by which was released on 2019. Download full G Quadruplex Nucleic Acids Books now! Available in PDF, ePub and Kindle....

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids
  • Author : Jonathan B. Chaires,David Graves
  • Publisher : Springer
  • Release Date : 2014-07-08
  • Total pages : 278
  • ISBN : 9780128103722
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Summary : Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell ...

Interplay Between Metal Ions and Nucleic Acids

Interplay Between Metal Ions and Nucleic Acids
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-01-02
  • Total pages : 353
  • ISBN : 9780128103722
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Summary : An overview of metal ion-nucleic acid interactions, the characterisation of which is covered in solution and in the solid state. It concentrates on modern developments, including topics ranging from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs)....

Biomedical Applications of Acridines

Biomedical Applications of Acridines
  • Author : Jan Ježek,Jan Hlaváček,Jaroslav Šebestík
  • Publisher : Springer
  • Release Date : 2017-08-15
  • Total pages : 237
  • ISBN : 9780128103722
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Summary : This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares ...

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids
  • Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
  • Publisher : Springer Science & Business
  • Release Date : 2014-04-22
  • Total pages : 599
  • ISBN : 9780128103722
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Summary : This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; ...

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-09-01
  • Total pages : 564
  • ISBN : 9780128103722
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Summary : The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human ...

Catalytically Active Nucleic Acids

Catalytically Active Nucleic Acids
  • Author : Harald Seitz,Frank Stahl,Johanna-Gabriela Walter
  • Publisher : Springer Nature
  • Release Date : 2019-09-30
  • Total pages : 123
  • ISBN : 9780128103722
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Summary : This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of ...

G quadruplex and Microorganisms

G quadruplex and Microorganisms
  • Author : Sara N. Richter
  • Publisher : MDPI
  • Release Date : 2019-08-19
  • Total pages : 208
  • ISBN : 9780128103722
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Summary : G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s ...

Medicinal Chemistry Approaches to Personalized Medicine

Medicinal Chemistry Approaches to Personalized Medicine
  • Author : Karen Lackey,Bruce Roth
  • Publisher : John Wiley & Sons
  • Release Date : 2013-11-22
  • Total pages : 408
  • ISBN : 9780128103722
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Summary : Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "...

Advances in Bionanomaterials II

Advances in Bionanomaterials II
  • Author : Stefano Piotto,Simona Concilio,Lucia Sessa,Federico Rossi
  • Publisher : Springer Nature
  • Release Date : 2020-05-29
  • Total pages : 260
  • ISBN : 9780128103722
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Summary : This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods ...

The Alkali Metal Ions Their Role for Life

The Alkali Metal Ions  Their Role for Life
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer
  • Release Date : 2016-02-09
  • Total pages : 628
  • ISBN : 9780128103722
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Summary : MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes ...