Therapeutic Antibody Engineering

Written By William R Strohl
Therapeutic Antibody Engineering
  • Publsiher : Elsevier
  • Release : 16 October 2012
  • ISBN : 1908818093
  • Pages : 696 pages
  • Rating : /5 from reviews
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Download or read book entitled Therapeutic Antibody Engineering by author: William R Strohl which was release on 16 October 2012 and published by Elsevier with total page 696 pages . This book available in PDF, EPUB and Kindle Format. The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : William R Strohl,Lila M Strohl
  • Publisher : Elsevier
  • Release Date : 2012-10-16
  • Total pages : 696
  • ISBN : 1908818093
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Summary : The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that ...

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-02-21
  • Total pages : 312
  • ISBN : 1908818093
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Summary : Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display ...

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • Total pages : 2544
  • ISBN : 1908818093
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Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial ...

Antibody Fc Engineering Towards Better Therapeutics

Antibody Fc Engineering  Towards Better Therapeutics
  • Author : Tianlei Ying,Rui Gong
  • Publisher : Frontiers Media SA
  • Release Date : 2018-12-21
  • Total pages : 212
  • ISBN : 1908818093
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Summary : Read online Antibody Fc Engineering Towards Better Therapeutics written by Tianlei Ying,Rui Gong, published by Frontiers Media SA which was released on 2018-12-21. Download full Antibody Fc Engineering Towards Better Therapeutics Books now! Available in PDF, ePub and Kindle....

New Horizons in Therapeutic Antibody Discovery

New Horizons in Therapeutic Antibody Discovery
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 212
  • ISBN : 1908818093
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Summary : Antibody drugs have become an increasingly significant component of the therapeutic landscape. Their success has been driven by some of their unique properties, in particular their very high specificity and selectivity, in contrast to the off-target liabilities of small molecules (SMs). Antibodies can bring additional functionality to the table with ...

Diagnostic and Therapeutic Antibodies

Diagnostic and Therapeutic Antibodies
  • Author : Andrew J. T. George,Catherine E. Urch
  • Publisher : Springer Science & Business Media
  • Release Date : 2000
  • Total pages : 477
  • ISBN : 1908818093
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Summary : Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few ...

Applications And Engineering Of Monoclonal Antibodies

Applications And Engineering Of Monoclonal Antibodies
  • Author : David J. King
  • Publisher : CRC Press
  • Release Date : 1998-11-27
  • Total pages : 249
  • ISBN : 1908818093
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Summary : A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and ...

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • Total pages : 2544
  • ISBN : 1908818093
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Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial ...

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • Total pages : 2544
  • ISBN : 1908818093
GET BOOK

Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial ...

Biosimilars of Monoclonal Antibodies

Biosimilars of Monoclonal Antibodies
  • Author : Cheng Liu,K. John Morrow, Jr.
  • Publisher : John Wiley & Sons
  • Release Date : 2016-12-09
  • Total pages : 704
  • ISBN : 1908818093
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Summary : Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, ...

Introduction to Antibody Engineering

Introduction to Antibody Engineering
  • Author : Florian Rüker,Gordana Wozniak-Knopp
  • Publisher : Springer Nature
  • Release Date : 2021-01-04
  • Total pages : 388
  • ISBN : 1908818093
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Summary : This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest ...

Antibodies

Antibodies
  • Author : G. Subramanian
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-07
  • Total pages : 314
  • ISBN : 1908818093
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Summary : If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an ...

Development of Antibody Based Therapeutics

Development of Antibody Based Therapeutics
  • Author : Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-04-24
  • Total pages : 426
  • ISBN : 1908818093
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Summary : Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection ...

Antibody Engineering

Antibody Engineering
  • Author : Patrick Chames
  • Publisher : Humana Press
  • Release Date : 2016-08-23
  • Total pages : 734
  • ISBN : 1908818093
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Summary : More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is ...

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
  • Author : Zhiqiang An
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-20
  • Total pages : 896
  • ISBN : 1908818093
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Summary : 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies ...