The Human Mitochondrial Genome

Written By Giuseppe Gasparre
The Human Mitochondrial Genome
  • Publsiher : Academic Press
  • Release : 19 August 2020
  • ISBN : 0128196564
  • Pages : 596 pages
  • Rating : /5 from reviews
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Download or read book entitled The Human Mitochondrial Genome by author: Giuseppe Gasparre which was release on 19 August 2020 and published by Academic Press with total page 596 pages . This book available in PDF, EPUB and Kindle Format. The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • Total pages : 596
  • ISBN : 0128196564
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Summary : The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, ...

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
  • Author : Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-09-05
  • Total pages : 271
  • ISBN : 0128196564
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Summary : Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, ...

The Evolution of Human Mitochondrial DNA

The Evolution of Human Mitochondrial DNA
  • Author : Rebecca Louise Cann
  • Publisher : Unknown
  • Release Date : 1982
  • Total pages : 650
  • ISBN : 0128196564
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Summary : Read online The Evolution of Human Mitochondrial DNA written by Rebecca Louise Cann, published by which was released on 1982. Download full The Evolution of Human Mitochondrial DNA Books now! Available in PDF, ePub and Kindle....

Normal and Disease related Sequence Variants of the Human Mitochondrial Genome

Normal and Disease related Sequence Variants of the Human Mitochondrial Genome
  • Author : Patcharee Lertrit
  • Publisher : Unknown
  • Release Date : 1992
  • Total pages : 424
  • ISBN : 0128196564
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Summary : Read online Normal and Disease related Sequence Variants of the Human Mitochondrial Genome written by Patcharee Lertrit, published by which was released on 1992. Download full Normal and Disease related Sequence Variants of the Human Mitochondrial Genome Books now! Available in PDF, ePub and Kindle....

High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics Function and Signals of Selection in Cancer

High throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics  Function  and Signals of Selection in Cancer
  • Author : Sneha Grandhi
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0128196564
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Summary : Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated ...

The Role of MGME1 in Maintenance of the Human Mitochondrial Genome

The Role of MGME1 in Maintenance of the Human Mitochondrial Genome
  • Author : Thomas Joseph James Nicholls
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 212
  • ISBN : 0128196564
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Summary : Read online The Role of MGME1 in Maintenance of the Human Mitochondrial Genome written by Thomas Joseph James Nicholls, published by which was released on 2014. Download full The Role of MGME1 in Maintenance of the Human Mitochondrial Genome Books now! Available in PDF, ePub and Kindle....

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
  • Author : Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
  • Publisher : Springer
  • Release Date : 2006-05-12
  • Total pages : 271
  • ISBN : 0128196564
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Summary : Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, ...

MITOMAP

MITOMAP
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1997
  • Total pages : 212
  • ISBN : 0128196564
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Summary : MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations, and their clinical characteristics, population associated variation, and gene-gene interactions....

Mitochondrial DNA Mitochondria Disease and Stem Cells

Mitochondrial DNA  Mitochondria  Disease and Stem Cells
  • Author : Justin C. St. John
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-09-27
  • Total pages : 190
  • ISBN : 0128196564
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Summary : This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these ...

Regulation of Human Mitochondrial Gene Expression

Regulation of Human Mitochondrial Gene Expression
  • Author : Maria Isabel Guadalupe Lopez Sanchez
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 212
  • ISBN : 0128196564
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Summary : Human mitochondrial DNA is a distinct, compact genetic system that encodes proteins crucial for energy metabolism in the cell. Due to its reduced size and relatively simple organisation, all the regulatory factors directing the expression of the mitochondrial genome are encoded by nuclear DNA. It is evident that mitochondrial gene ...

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology
  • Author : Vivian Edesan Reyes
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 166
  • ISBN : 0128196564
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Summary : Read online Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology written by Vivian Edesan Reyes, published by which was released on 2008. Download full Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology Books now! Available in PDF, ePub and Kindle....

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer
  • Author : Mansoureh Akouchekian
  • Publisher : Cuvillier Verlag
  • Release Date : 2008
  • Total pages : 80
  • ISBN : 0128196564
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Summary : Read online Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer written by Mansoureh Akouchekian, published by Cuvillier Verlag which was released on 2008. Download full Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer Books now! Available in PDF, ePub and Kindle....

Human Mitochondrial DNA Evolution in Papua New Guinea

Human Mitochondrial DNA Evolution in Papua New Guinea
  • Author : Mark Allen Stoneking
  • Publisher : Unknown
  • Release Date : 1988
  • Total pages : 648
  • ISBN : 0128196564
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Summary : Read online Human Mitochondrial DNA Evolution in Papua New Guinea written by Mark Allen Stoneking, published by which was released on 1988. Download full Human Mitochondrial DNA Evolution in Papua New Guinea Books now! Available in PDF, ePub and Kindle....

Mitochondrial Diseases

Mitochondrial Diseases
  • Author : Wiley
  • Publisher : John Wiley & Sons
  • Release Date : 2013-07-12
  • Total pages : 140
  • ISBN : 0128196564
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Summary : This collection of reviews and protocols provides the reader with an introduction to the current state of knowledge on how various diseases are related to mitochondrial dysfunction. Mitochondria contain their own genome, a small, circular double-stranded DNA (mtDNA), and alterations in mtDNA may play an important role in the multistep ...

The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release Date : 2020-07-23
  • Total pages : 596
  • ISBN : 0128196564
GET BOOK

Summary : The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, ...