The History of Alternative Test Methods in Toxicology

Written By Anonim
The History of Alternative Test Methods in Toxicology
  • Publsiher : Academic Press
  • Release : 20 October 2018
  • ISBN : 0128136987
  • Pages : 352 pages
  • Rating : /5 from reviews
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Download or read book entitled The History of Alternative Test Methods in Toxicology by author: Anonim which was release on 20 October 2018 and published by Academic Press with total page 352 pages . This book available in PDF, EPUB and Kindle Format. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-20
  • Total pages : 352
  • ISBN : 0128136987
GET BOOK

Summary : The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history ...

Alternative Toxicological Methods

Alternative Toxicological Methods
  • Author : Harry Salem,Sidney A. Katz
  • Publisher : CRC Press
  • Release Date : 2003-03-26
  • Total pages : 616
  • ISBN : 0128136987
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Summary : Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist...

Departments of Labor and Health and Human Services Education and Related Agencies Appropriations

Departments of Labor  and Health and Human Services  Education  and Related Agencies Appropriations
  • Author : United States. Congress. Senate. Committee on Appropriations
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online Departments of Labor and Health and Human Services Education and Related Agencies Appropriations written by United States. Congress. Senate. Committee on Appropriations, published by which was released on 2005. Download full Departments of Labor and Health and Human Services Education and Related Agencies Appropriations Books now! Available in PDF, ...

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for Fiscal Year 2006

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for Fiscal Year 2006
  • Author : United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 677
  • ISBN : 0128136987
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Summary : Read online Departments of Labor Health and Human Services Education and Related Agencies Appropriations for Fiscal Year 2006 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies, published by which was released on 2006. Download full Departments of Labor ...

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for Fiscal Year 2007

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for Fiscal Year 2007
  • Author : United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online Departments of Labor Health and Human Services Education and Related Agencies Appropriations for Fiscal Year 2007 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies, published by which was released on 2006. Download full Departments of Labor ...

Proceedings of the Indian National Science Academy

Proceedings of the Indian National Science Academy
  • Author : Indian National Science Academy
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online Proceedings of the Indian National Science Academy written by Indian National Science Academy, published by which was released on 2001. Download full Proceedings of the Indian National Science Academy Books now! Available in PDF, ePub and Kindle....

Principles and Methods of Toxicology Fifth Edition

Principles and Methods of Toxicology  Fifth Edition
  • Author : A. Wallace Hayes
  • Publisher : CRC Press
  • Release Date : 2007-09-25
  • Total pages : 2296
  • ISBN : 0128136987
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Summary : Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and ...

Hazardous Waste Hazardous Materials

Hazardous Waste   Hazardous Materials
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1988
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online Hazardous Waste Hazardous Materials written by , published by which was released on 1988. Download full Hazardous Waste Hazardous Materials Books now! Available in PDF, ePub and Kindle....

Proceedings

Proceedings
  • Author : Indian National Science Academy
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online Proceedings written by Indian National Science Academy, published by which was released on 2001. Download full Proceedings Books now! Available in PDF, ePub and Kindle....

United States Code

United States Code
  • Author : United States
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online United States Code written by United States, published by which was released on 2001. Download full United States Code Books now! Available in PDF, ePub and Kindle....

Blast

Blast
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2002
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online Blast written by , published by which was released on 2002. Download full Blast Books now! Available in PDF, ePub and Kindle....

United States Code Annotated

United States Code Annotated
  • Author : United States
  • Publisher : Unknown
  • Release Date : 1927
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online United States Code Annotated written by United States, published by which was released on 1927. Download full United States Code Annotated Books now! Available in PDF, ePub and Kindle....

Reviews of Environmental Contamination and Toxicology

Reviews of Environmental Contamination and Toxicology
  • Author : George W. Ware
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 172
  • ISBN : 0128136987
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Summary : International concern in scientific, industrial, and governmental communi ties over traces of xenobiotics in foods and in both abiotic and biotic en vironments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published research papers and progress reports, and archival documentations. These three international publications ...

ATLA

ATLA
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2002
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Read online ATLA written by , published by which was released on 2002. Download full ATLA Books now! Available in PDF, ePub and Kindle....

Animals and Alternatives in Testing

Animals and Alternatives in Testing
  • Author : Joanne Zurlo,Deborah Rudacille,Alan M. Goldberg
  • Publisher : Unknown
  • Release Date : 1994
  • Total pages : 86
  • ISBN : 0128136987
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Summary : Read online Animals and Alternatives in Testing written by Joanne Zurlo,Deborah Rudacille,Alan M. Goldberg, published by which was released on 1994. Download full Animals and Alternatives in Testing Books now! Available in PDF, ePub and Kindle....