Target Discovery and Validation

Written By Alleyn T. Plowright
Target Discovery and Validation
  • Publsiher : John Wiley & Sons
  • Release : 31 December 2019
  • ISBN : 3527345299
  • Pages : 400 pages
  • Rating : /5 from reviews
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Download or read book entitled Target Discovery and Validation by author: Alleyn T. Plowright which was release on 31 December 2019 and published by John Wiley & Sons with total page 400 pages . This book available in PDF, EPUB and Kindle Format. The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Target Discovery and Validation

Target Discovery and Validation
  • Author : Alleyn T. Plowright
  • Publisher : John Wiley & Sons
  • Release Date : 2019-12-31
  • Total pages : 400
  • ISBN : 3527345299
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Summary : The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses ...

Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
  • Author : Jurgen Moll,Riccardo Colombo
  • Publisher : Humana Press
  • Release Date : 2016-05-01
  • Total pages : 388
  • ISBN : 3527345299
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Summary : This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."...

Target Validation in Drug Discovery

Target Validation in Drug Discovery
  • Author : Brian W. Metcalf,Susan Dillon
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Total pages : 296
  • ISBN : 3527345299
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Summary : This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases ...

Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
  • Author : Jürgen Moll,Sebastian Carotta
  • Publisher : Humana Press
  • Release Date : 2019-04-12
  • Total pages : 318
  • ISBN : 3527345299
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Summary : This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written ...

Comprehensive Analysis of Parasite Biology

Comprehensive Analysis of Parasite Biology
  • Author : Sylke M?ller,Rachel Cerdan,Ovidiu Radulescu,Paul M. Selzer
  • Publisher : John Wiley & Sons
  • Release Date : 2016-10-17
  • Total pages : 576
  • ISBN : 3527345299
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Summary : Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism ...

Target Discovery and Validation Reviews and Protocols

Target Discovery and Validation Reviews and Protocols
  • Author : Mouldy Sioud
  • Publisher : Springer Science & Business Media
  • Release Date : 2007
  • Total pages : 356
  • ISBN : 3527345299
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Summary : Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for ...

Target Discovery and Validation

Target Discovery and Validation
  • Author : Mouldy Sioud
  • Publisher : Springer Science & Business Media
  • Release Date : 2007
  • Total pages : 384
  • ISBN : 3527345299
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Summary : Annotation These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough ...

Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-11-21
  • Total pages : 690
  • ISBN : 3527345299
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Summary : Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, ...

Imaging in Drug Discovery and Early Clinical Trials

Imaging in Drug Discovery and Early Clinical Trials
  • Author : Markus Rudin
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-07-11
  • Total pages : 392
  • ISBN : 3527345299
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Summary : This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging ...

In Silico Technologies in Drug Target Identification and Validation

In Silico Technologies in Drug Target Identification and Validation
  • Author : Darryl Leon,Scott Markel
  • Publisher : CRC Press
  • Release Date : 2006-06-13
  • Total pages : 504
  • ISBN : 3527345299
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Summary : The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Identification and Validation ...

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • Total pages : 594
  • ISBN : 3527345299
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Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on ...

Real World Drug Discovery

Real World Drug Discovery
  • Author : Robert M. Rydzewski
  • Publisher : Elsevier
  • Release Date : 2010-07-07
  • Total pages : 600
  • ISBN : 3527345299
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Summary : Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, ...

New Approaches to Drug Discovery

New Approaches to Drug Discovery
  • Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
  • Publisher : Springer
  • Release Date : 2016-03-30
  • Total pages : 341
  • ISBN : 3527345299
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Summary : This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug ...

Methods and Techniques in Drug Discovery

Methods and Techniques in Drug Discovery
  • Author : John Sterling,Ellyn J. T. D. Kerr,Shannon Simons
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 266
  • ISBN : 3527345299
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Summary : Read online Methods and Techniques in Drug Discovery written by John Sterling,Ellyn J. T. D. Kerr,Shannon Simons, published by which was released on 2005. Download full Methods and Techniques in Drug Discovery Books now! Available in PDF, ePub and Kindle....

Drug Discovery and Development

Drug Discovery and Development
  • Author : Ramarao Poduri
  • Publisher : Springer Nature
  • Release Date : 2021-04-14
  • Total pages : 212
  • ISBN : 3527345299
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Summary : Read online Drug Discovery and Development written by Ramarao Poduri, published by Springer Nature which was released on . Download full Drug Discovery and Development Books now! Available in PDF, ePub and Kindle....