Target Validation In Drug Discovery

Download or read book entitled Target Validation in Drug Discovery by author: Brian W. Metcalf which was release on 28 April 2011 and published by Elsevier with total page 296 pages . This book available in PDF, EPUB and Kindle Format. This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.