Small Molecule Drug Discovery

Written By Andrea Trabocchi
Small Molecule Drug Discovery
  • Publsiher : Elsevier
  • Release : 23 November 2019
  • ISBN : 0128183500
  • Pages : 356 pages
  • Rating : /5 from reviews
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Download or read book entitled Small Molecule Drug Discovery by author: Andrea Trabocchi which was release on 23 November 2019 and published by Elsevier with total page 356 pages . This book available in PDF, EPUB and Kindle Format. Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release Date : 2019-11-23
  • Total pages : 356
  • ISBN : 0128183500
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Summary : Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
  • Publisher : Academic Press
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0128183500
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Summary : Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the ...

Small Molecule Medicinal Chemistry

Small Molecule Medicinal Chemistry
  • Author : Werngard Czechtizky,Peter Hamley
  • Publisher : John Wiley & Sons
  • Release Date : 2015-11-02
  • Total pages : 528
  • ISBN : 0128183500
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Summary : Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Michael Stocks
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0128183500
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Summary : Drug discovery of small molecules from target selection through to clinical evaluation is a very complex, challenging but rewarding area of drug discovery. There are many obstacles along the journey from initial hit-finding activities, through optimization of compounds and eventually to delivery of robust candidate drugs (CDs) for clinical evaluation. ...

Early stage Small molecule Drug Discovery

Early stage Small molecule Drug Discovery
  • Author : Wellcome Trust (London, England)
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 1
  • ISBN : 0128183500
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Summary : Read online Early stage Small molecule Drug Discovery written by Wellcome Trust (London, England), published by which was released on 2011. Download full Early stage Small molecule Drug Discovery Books now! Available in PDF, ePub and Kindle....

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : James Samanen
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0128183500
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Summary : Biotechnology has given rise to a broad range of biotherapies or biologics, including biomolecular drugs, vaccines, cell or gene therapies. This chapter focuses on biomolecular drugs, namely monoclonal antibodies (Mabs), cytokines, tissue growth factors and therapeutic proteins. Prior to the US approval of recombinant human insulin in 1982, biomolecular drugs were ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : James Samanen
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0128183500
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Summary : Successful drugs have a good return on investment by bringing in considerably more revenue than the expenses of discovery, development, and manufacturing. Successful drugs pay for all drug projects, those that fail and those that have yet to fail or succeed. Most research and development (R&D) projects fail. Since ...

The Science and Business of Drug Discovery

The Science and Business of Drug Discovery
  • Author : Edward D. Zanders
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-07-08
  • Total pages : 397
  • ISBN : 0128183500
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Summary : The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting ...

Drug Discovery and Development

Drug Discovery and Development
  • Author : Omboon Vallisuta,Suleiman Olimat
  • Publisher : BoD – Books on Demand
  • Release Date : 2015-06-03
  • Total pages : 330
  • ISBN : 0128183500
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Summary : It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse ...

Applied Biophysics for Drug Discovery

Applied Biophysics for Drug Discovery
  • Author : Donald Huddler,Edward R. Zartler
  • Publisher : John Wiley & Sons
  • Release Date : 2017-10-02
  • Total pages : 312
  • ISBN : 0128183500
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Summary : 13.2.1 Protein Dynamics of SA WT and S1 Mutant DHFR in Apo and Bound States...

Successful Drug Discovery Volume 5

Successful Drug Discovery  Volume 5
  • Author : Janos Fischer,Christian Klein,Wayne E. Childers
  • Publisher : John Wiley & Sons
  • Release Date : 2021-02-12
  • Total pages : 320
  • ISBN : 0128183500
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Summary : Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drug's discovery and development. Case studies of drugs from different ...

Drug Discovery Conference 2008

Drug Discovery Conference 2008
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 5
  • ISBN : 0128183500
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Summary : Read online Drug Discovery Conference 2008 written by , published by which was released on 2008. Download full Drug Discovery Conference 2008 Books now! Available in PDF, ePub and Kindle....

Application of Computational Methods for Kinase Small Molecule Drug Discovery and Design

Application of Computational Methods for Kinase Small Molecule Drug Discovery and Design
  • Author : Abdulkarim Najjar
  • Publisher : Unknown
  • Release Date : 2018*
  • Total pages : 212
  • ISBN : 0128183500
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Summary : Kinase; PKMYT1; PRK1; EGFR; IGF-1R; PDGFR-[beta]; VEDFR2; kinase inhibitors; computer-aided drug design; drug discovery...

Successful Drug Discovery

Successful Drug Discovery
  • Author : János Fischer,Christian Klein,Wayne E. Childers
  • Publisher : John Wiley & Sons
  • Release Date : 2019-10-07
  • Total pages : 272
  • ISBN : 0128183500
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Summary : Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes ...

Fragment based Drug Discovery

Fragment based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-23
  • Total pages : 528
  • ISBN : 0128183500
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Summary : From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of ...