RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy

Written By Sijin Guo
RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy
  • Publsiher : Unknown
  • Release : 07 May 2021
  • ISBN :
  • Pages : pages
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GET THIS BOOKRNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy


Download or read book entitled RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy by author: Sijin Guo which was release on 07 May 2021 and published by Unknown with total page pages . This book available in PDF, EPUB and Kindle Format. Ribonucleic acid (RNA) nanotechnology is a rapidly emerging field that focuses on the nanostructure design, construction, and application in biotechnology and biomedicine. Unlike other biomacromolecules, RNA is more flexible in structure and more versatile in functionality. On the other hand, RNA is a naturally-occurring biopolymer, making them more biocompatible compared to other nanomaterials. Thus, RNA can serve as a building block to construct nanoparticles as drug delivery platform for cancer therapy. This dissertation primarily describes a fundamental study that explores the immune-compatibility of RNA nanoparticles, as well as the use of thermostable RNA nanoparticles to specifically deliver therapeutics for efficient cancer therapy without causing toxicity. Firstly, RNA polygons that have identical size but varying shapes, or same shape but with different sizes were constructed as study model. The RNA nanoparticles were found to be immunologically inert, indicating that RNA nanoparticles are safe drug carriers without triggering immune responses. On the other hand, they can elicit significant immunomodulation by extending the nanoparticles with special sequences. Specifically, this immunomodulation was found to be size, shape, sequence-dependent, demonstrating the potential of using RNA nanoparticles in immunotherapy. Secondly, the use of a thermostable RNA nanoparticle for solubilizing and high-density loading chemotherapeutic drugs for cancer inhibition is reported. Small chemotherapeutic drugs possess significant anti-cancer activity, but their clinical applications were greatly limited by the poor biocompatibility such as water-insolubility. By chemically conjugating water-insoluble drugs to RNA, the RNA nanoparticles dramatically improved drug water-solubility. An ultra-thermostable RNA four-way junction nanoparticle was able to covalently load twenty-four copies of paclitaxel without nanoparticle dissociation or unfolding. After intravenous administration, the resulting RNA-paclitaxel nanoparticles harboring specific cancer targeting ligand significantly inhibited breast cancer tumor in mice. The toxicity in organs and immune responses in mice were almost undetectable. Besides paclitaxel, this RNA-drug conjugation was applied to another anti-cancer drug, camptothecin, and showed significant inhibitory effect on tumor growth. Furthermore, an acid labile linker was developed within RNA-drug conjugates, aiming at controlling pH-responsive drug release in acidic tumor environment to improve drug efficacy. Thirdly, a three-dimensional RNA cube was constructed and explored as a multi-functional drug carrier by incorporation with different therapeutic modules. This multi-functional RNA cube is able to load chemotherapeutic drug, immunostimulatory molecule, or short-interfering RNA for enhanced cellular effects in vitro. What’s more, the RNA cube can be manipulated to become reconfigurable, suggesting the great potential of drug encapsulation and release for in vivo applications. Collectively, these findings demonstrate that RNA nanoparticles can serve as a biocompatible drug delivery platform for effective cancer therapy with favorable safety profile.

RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy

RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy
  • Author : Sijin Guo
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 212
  • ISBN :
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Summary : Ribonucleic acid (RNA) nanotechnology is a rapidly emerging field that focuses on the nanostructure design, construction, and application in biotechnology and biomedicine. Unlike other biomacromolecules, RNA is more flexible in structure and more versatile in functionality. On the other hand, RNA is a naturally-occurring biopolymer, making them more biocompatible compared ...

Handbook of Nanomaterials for Cancer Theranostics

Handbook of Nanomaterials for Cancer Theranostics
  • Author : Joao Conde
  • Publisher : Elsevier
  • Release Date : 2018-06-27
  • Total pages : 606
  • ISBN :
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Summary : Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with ...

Nanobiotechnology in Diagnosis Drug Delivery and Treatment

Nanobiotechnology in Diagnosis  Drug Delivery and Treatment
  • Author : Mahendra Rai,Mehdi Razzaghi-Abyaneh,Avinash P. Ingle
  • Publisher : John Wiley & Sons
  • Release Date : 2020-11-17
  • Total pages : 416
  • ISBN :
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Summary : Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and ...

Dendrimer Based Nanotherapeutics

Dendrimer Based Nanotherapeutics
  • Author : Prashant Kesharwani
  • Publisher : Academic Press
  • Release Date : 2021-04-27
  • Total pages : 484
  • ISBN :
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Summary : Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, ...

Noble and Precious Metals

Noble and Precious Metals
  • Author : Mohindar Seehra,Alan Bristow
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-07-04
  • Total pages : 430
  • ISBN :
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Summary : The use of copper, silver, gold and platinum in jewelry as a measure of wealth is well known. This book contains 19 chapters written by international authors on other uses and applications of noble and precious metals (copper, silver, gold, platinum, palladium, iridium, osmium, rhodium, ruthenium, and rhenium). The topics covered ...

Multifunctional Nanoparticles for Drug Delivery Applications

Multifunctional Nanoparticles for Drug Delivery Applications
  • Author : Sonke Svenson,Robert K. Prud'homme
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-22
  • Total pages : 374
  • ISBN :
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Summary : This book presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles....

Cancer New Insights for the Healthcare Professional 2011 Edition

Cancer  New Insights for the Healthcare Professional  2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Total pages : 3937
  • ISBN :
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Summary : Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook ...

Standard Poor s Stock Reports

Standard   Poor s Stock Reports
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2011-03
  • Total pages : 212
  • ISBN :
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Summary : Read online Standard Poor s Stock Reports written by , published by which was released on 2011-03. Download full Standard Poor s Stock Reports Books now! Available in PDF, ePub and Kindle....

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 212
  • ISBN :
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Summary : Read online Genetic Engineering Biotechnology News written by , published by which was released on 2009. Download full Genetic Engineering Biotechnology News Books now! Available in PDF, ePub and Kindle....

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2011 Edition

Issues in Pharmacology  Pharmacy  Drug Research  and Drug Innovation  2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Total pages : 4229
  • ISBN :
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Summary : Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ ...

World Congress on Medical Physics and Biomedical Engineering May 26 31 2012 Beijing China

World Congress on Medical Physics and Biomedical Engineering May 26 31  2012  Beijing  China
  • Author : Mian Long
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-02-11
  • Total pages : 2345
  • ISBN :
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Summary : The congress’s unique structure represents the two dimensions of technology and medicine: 13 themes on science and medical technologies intersect with five challenging main topics of medicine to create a maximum of synergy and integration of aspects on research, development and application. Each of the congress themes was chaired by ...

Issues in General Science and Scientific Theory and Method 2011 Edition

Issues in General Science and Scientific Theory and Method  2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Total pages : 3278
  • ISBN :
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Summary : Issues in General Science and Scientific Theory and Method: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science and Scientific Theory and Method. The editors have built Issues in General Science and Scientific Theory and Method: 2011 Edition on the vast information databases of ScholarlyNews.™ ...

Issues in Life Sciences Molecular Biology 2011 Edition

Issues in Life Sciences  Molecular Biology  2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Total pages : 3330
  • ISBN :
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Summary : Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular ...

Issues in Analysis Measurement Monitoring Imaging and Remote Sensing Technology 2011 Edition

Issues in Analysis  Measurement  Monitoring  Imaging  and Remote Sensing Technology  2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Total pages : 2350
  • ISBN :
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Summary : Issues in Analysis, Measurement, Monitoring, Imaging, and Remote Sensing Technology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Analysis, Measurement, Monitoring, Imaging, and Remote Sensing Technology. The editors have built Issues in Analysis, Measurement, Monitoring, Imaging, and Remote Sensing Technology: 2011 Edition on the vast information ...

Issues in Chemistry and General Chemical Research 2011 Edition

Issues in Chemistry and General Chemical Research  2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Total pages : 6580
  • ISBN :
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Summary : Issues in Chemistry and General Chemical Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemistry and General Chemical Research. The editors have built Issues in Chemistry and General Chemical Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ...