Polymers and Nanomaterials for Gene Therapy

Written By Ravin Narain
Polymers and Nanomaterials for Gene Therapy
  • Publsiher : Woodhead Publishing
  • Release : 09 January 2016
  • ISBN : 0081005210
  • Pages : 302 pages
  • Rating : /5 from reviews
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Download or read book entitled Polymers and Nanomaterials for Gene Therapy by author: Ravin Narain which was release on 09 January 2016 and published by Woodhead Publishing with total page 302 pages . This book available in PDF, EPUB and Kindle Format. Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Polymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy
  • Author : Ravin Narain
  • Publisher : Woodhead Publishing
  • Release Date : 2016-01-09
  • Total pages : 302
  • ISBN : 0081005210
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Summary : Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides ...

Gene therapy

Gene therapy
  • Author : Surendra Nimesh
  • Publisher : Elsevier
  • Release Date : 2013-10-31
  • Total pages : 380
  • ISBN : 0081005210
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Summary : Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be ...

Enhanced Polymeric Nanoparticles for Gene Delivery

Enhanced Polymeric Nanoparticles for Gene Delivery
  • Author : Jordan Jamieson Green,Massachusetts Institute of Technology. Department of Biological Engineering
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 228
  • ISBN : 0081005210
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Summary : (cont.) We show that small modifications to the termini of a polymer can significantly increase its in vivo activity and demonstrate potential utility of these polymers in the fields of cancer therapy, genetic vaccines, and stem cell engineering. As the enhanced polymeric gene delivery nanoparticles described here have many attractive ...

Theory Techniques and Applications of Nanotechnology in Gene Silencing

Theory  Techniques and Applications of Nanotechnology in Gene Silencing
  • Author : Surendra Nimesh,Ramesh Chandra
  • Publisher : River Publishers
  • Release Date : 2012-02-06
  • Total pages : 193
  • ISBN : 0081005210
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Summary : Gene silencing mediated through short interfering RNAs (siRNAs) is rapidly emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence there arises a need to develop a delivery system which can ...

Development and Characterization of Biodegradable Polymeric Nanoparticles for Gene Delivery

Development and Characterization of Biodegradable Polymeric Nanoparticles for Gene Delivery
  • Author : Nashid Farhan
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 206
  • ISBN : 0081005210
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Summary : Gene therapy offers the hope to alleviate the diseases for which there is no permanent cure including genetic disorders, HIV, and cancer. The nucleic acids cannot transfect the cells by themselves as the degradation occurs before they reach the nucleus. Viral vectors initially showed the promise to deliver the nucleic ...

Development of Novel Polymeric Nanoparticles for Cancer Gene Therapy

Development of Novel Polymeric Nanoparticles for Cancer Gene Therapy
  • Author : Hong Yao
  • Publisher : Unknown
  • Release Date : 2017-01-26
  • Total pages : 212
  • ISBN : 0081005210
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Summary : Read online Development of Novel Polymeric Nanoparticles for Cancer Gene Therapy written by Hong Yao, published by which was released on 2017-01-26. Download full Development of Novel Polymeric Nanoparticles for Cancer Gene Therapy Books now! Available in PDF, ePub and Kindle....

Advances in Polymeric Nanomaterials for Biomedical Applications

Advances in Polymeric Nanomaterials for Biomedical Applications
  • Author : Anil Kumar Bajpai,Rajesh Kumar Saini
  • Publisher : Elsevier
  • Release Date : 2021-04-02
  • Total pages : 388
  • ISBN : 0081005210
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Summary : Advances in Polymeric Nanomaterials for Biomedical Applications examines advanced polymer synthetic strategies for developing novel biomaterials for use in medicine. With a strong focus on fundamentals and structure, the authors also explore their fabrication, along with their current and potential biomedical applications. The book begins with a look at the ...

Smart Internal Stimulus Responsive Nanocarriers for Drug and Gene Delivery

Smart Internal Stimulus Responsive Nanocarriers for Drug and Gene Delivery
  • Author : Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2015-12-01
  • Total pages : 115
  • ISBN : 0081005210
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Summary : The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by ...

Bio Inspired Nanomaterials and Applications

Bio Inspired Nanomaterials and Applications
  • Author : Donglu Shi
  • Publisher : World Scientific
  • Release Date : 2014-11-18
  • Total pages : 256
  • ISBN : 0081005210
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Summary : This book intends to provide an up-to-date information in the field of nanobiomedicine. The focus of the book is on the basic concepts and recent developments in the field of nanotechnology. This book covers a broad spectrum of nanomaterials processing, structural characteristics, and related properties and will include bio-probes, medical ...

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery
  • Author : Zhongwei Gu
  • Publisher : John Wiley & Sons
  • Release Date : 2015-03-09
  • Total pages : 360
  • ISBN : 0081005210
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Summary : Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes ...

Smart External Stimulus Responsive Nanocarriers for Drug and Gene Delivery

Smart External Stimulus Responsive Nanocarriers for Drug and Gene Delivery
  • Author : Mahdi Karimi,Parham Sahandi Zangabad,Amir Ghasemi,Michael R Hamblin
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2015-12-01
  • Total pages : 155
  • ISBN : 0081005210
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Summary : The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by ...

Polymeric Gene Delivery

Polymeric Gene Delivery
  • Author : Mansoor M. Amiji
  • Publisher : CRC Press
  • Release Date : 2004-09-29
  • Total pages : 704
  • ISBN : 0081005210
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Summary : To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages ...

Polymeric Nanomaterials in Nanotherapeutics

Polymeric Nanomaterials in Nanotherapeutics
  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2018-10-26
  • Total pages : 558
  • ISBN : 0081005210
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Summary : Polymeric Nanomaterials in Nanotherapeutics describes how polymeric nanosensors and nanorobotics are used for biomedical instrumentation, surgery, diagnosis and targeted drug delivery for cancer, pharmacokinetics, monitoring of diabetes and healthcare. Key areas of coverage include drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy ...

Advances in Nanomaterials for Drug Delivery

Advances in Nanomaterials for Drug Delivery
  • Author : Mahdi Karimi,Maryam Rad Mansouri,Navid Rabiee,Michael R Hamblin
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2018-12-05
  • Total pages : 78
  • ISBN : 0081005210
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Summary : Nanomedicine is a developing field, which includes different disciplines such as material science, chemistry, engineering and medicine devoted to the design, synthesis and construction of high-tech nanostructures. The ability of these structures to have their chemical and physical properties tuned by structural modification, has allowed their use in drug delivery ...

Functional Polymer for Drug and Gene Delivery

Functional Polymer for Drug and Gene Delivery
  • Author : Peisheng Xu
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 237
  • ISBN : 0081005210
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Summary : Polymeric nanoparticles have been widely explored as carriers for cancer-targeted delivery of therapeutic agents due to their advantages of few side effects and enhanced therapeutic efficacy. Polymer nanoparticles developed to date, however, have problems of stability, slow cellular internalization, low therapeutic efficiency in cancer chemotherapy and low transfection efficiency in ...