Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Written By Sheila Annie Peters
Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
  • Publsiher : John Wiley & Sons
  • Release : 17 February 2012
  • ISBN : 1118140303
  • Pages : 450 pages
  • Rating : /5 from reviews
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Download or read book entitled Physiologically Based Pharmacokinetic PBPK Modeling and Simulations by author: Sheila Annie Peters which was release on 17 February 2012 and published by John Wiley & Sons with total page 450 pages . This book available in PDF, EPUB and Kindle Format. The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
  • Publisher : John Wiley & Sons
  • Release Date : 2005-06-14
  • Total pages : 420
  • ISBN : 1118140303
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Summary : A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book ...

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
  • Author : Sheila Annie Peters
  • Publisher : John Wiley & Sons
  • Release Date : 2012-02-17
  • Total pages : 450
  • ISBN : 1118140303
GET BOOK

Summary : The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of ...

Physiologically Based Pharmacokinetic PBPK Modeling

Physiologically Based Pharmacokinetic  PBPK  Modeling
  • Author : Jeffrey W. Fisher,Jeffery M. Gearhart,Zhoumeng Lin
  • Publisher : Academic Press
  • Release Date : 2020-06-04
  • Total pages : 346
  • ISBN : 1118140303
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Summary : Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use ...

Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment

Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 40
  • ISBN : 1118140303
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Summary : Physiologically-based pharmacokinetic (PBPK) modeling has become the tool of choice to develop estimates of target site dosimetries in animals and humans for risk assessment purposes. PBPK model compartments correspond directly to the tissues and organs in the species. The drawbacks of PBPK modeling primarily relate to the time, effort and ...

Translational Physiologically based Pharmacokinetic PBPK Modeling and Simulation to Support Drug Development and Pharmacotherapy

Translational Physiologically based Pharmacokinetic  PBPK  Modeling and Simulation to Support Drug Development and Pharmacotherapy
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 1118140303
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Summary : Read online Translational Physiologically based Pharmacokinetic PBPK Modeling and Simulation to Support Drug Development and Pharmacotherapy written by , published by which was released on 2018. Download full Translational Physiologically based Pharmacokinetic PBPK Modeling and Simulation to Support Drug Development and Pharmacotherapy Books now! Available in PDF, ePub and Kindle....

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Jasmine Davda
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2009-08
  • Total pages : 112
  • ISBN : 1118140303
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Summary : This book describes the application of physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of therapeutic monoclonal antibodies (MAbs). These macromolecules exhibit distinctly different pharmacokinetic features compared with conventional small-molecule drugs. A PBPK model was developed to characterize the biodistribution of the pancarcinoma MAb CC49 in normal and neoplastic ...

Physiologically Based Pharmacokinetic PBPK Model Development of Perfluorocarboxylic Acids for Rats and Humans

Physiologically Based Pharmacokinetic  PBPK  Model Development of Perfluorocarboxylic Acids for Rats and Humans
  • Author : 晴美
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 1118140303
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Summary : Read online Physiologically Based Pharmacokinetic PBPK Model Development of Perfluorocarboxylic Acids for Rats and Humans written by 晴美, published by which was released on 2013. Download full Physiologically Based Pharmacokinetic PBPK Model Development of Perfluorocarboxylic Acids for Rats and Humans Books now! Available in PDF, ePub and Kindle....

Physiologically Based Pharmacokinetic Modeling of Nanoparticles in Rodents

Physiologically Based Pharmacokinetic Modeling of Nanoparticles in Rodents
  • Author : Xiaowan Li
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 26
  • ISBN : 1118140303
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Summary : A variety of nanoparticles are under development for medicine, energy, food and cosmetics. Both organic and inorganic nanoparticles are playing an increased role in industrial and medical applications. However, little is known about their distribution and effects on the human body, and as a result concerns exist about potential health ...

Computational Toxicology

Computational Toxicology
  • Author : Patricia Ruiz,Xiaoxia Yang,Annie Lumen,Jeff Fisher
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Total pages : 274
  • ISBN : 1118140303
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Summary : Human health risk assessment is “the process to estimate the nature and probability of adverse health effects in humans who may be exposed to chemicals in contaminated environmental media, now or in the future.” Currently, most data required for human risk assessment are derived from toxicological studies conducted in laboratory ...

Consequences of a Lack of Adult Intravenous Data on the Prediction Accuracy of Pediatric Physiologically Based Pharmacokinetic PBPK Modeling

Consequences of a Lack of Adult Intravenous Data on the Prediction Accuracy of Pediatric Physiologically Based Pharmacokinetic  PBPK  Modeling
  • Author : Rabiya Chandani
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 130
  • ISBN : 1118140303
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Summary : Lack of pediatric clinical data has led to a large gap in knowledge concerning drug efficacy, safety and dosing guidelines within the pediatric population. Many pediatric off-label doses are based largely on adult studies with little or no pediatric experience; this has the potential to lead to treatment failures, toxicities, ...

Mechanistic Physiologically Based Pharmacokinetic PBPK Modeling of Renal and Systemic Disposition of Drugs and Metabolites

Mechanistic Physiologically Based Pharmacokinetic  PBPK  Modeling of Renal and Systemic Disposition of Drugs and Metabolites
  • Author : Weize Huang
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 263
  • ISBN : 1118140303
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Summary : Physiologically-based pharmacokinetic (PBPK) models integrate system specific anatomy and physiology information with drug specific physicochemical and pharmacokinetic properties to predict drug disposition. Such integration permits items, events, processes, and pathways to communicate and influence each other interactively. By taking advantage of such mechanistic nature of PBPK modeling, drug dispositions under ...

CYP450 mediated Drug drug Interactions

CYP450 mediated Drug drug Interactions
  • Author : Niloufar Marsousi
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 214
  • ISBN : 1118140303
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Summary : Read online CYP450 mediated Drug drug Interactions written by Niloufar Marsousi, published by which was released on 2017. Download full CYP450 mediated Drug drug Interactions Books now! Available in PDF, ePub and Kindle....

A Parameter Analysis of a Physiologically Based Pharmacokinetic PBPK Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo p dioxin in the Mouse

A Parameter Analysis of a Physiologically Based Pharmacokinetic  PBPK  Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo p dioxin in the Mouse
  • Author : Jessica Leigh Wagner
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 60
  • ISBN : 1118140303
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Summary : Read online A Parameter Analysis of a Physiologically Based Pharmacokinetic PBPK Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo p dioxin in the Mouse written by Jessica Leigh Wagner, published by which was released on 2017. Download full A Parameter Analysis of a Physiologically Based Pharmacokinetic PBPK Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo ...

Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic PBPK Modeling

Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic  PBPK  Modeling
  • Author : Dirk P. Yamamoto
  • Publisher : Unknown
  • Release Date : 2010
  • Total pages : 376
  • ISBN : 1118140303
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Summary : Read online Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic PBPK Modeling written by Dirk P. Yamamoto, published by which was released on 2010. Download full Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic PBPK Modeling Books now! Available ...

Physiologically Based Pharmacokinetic Models for the Systemic Transport of Trichloroethylene

Physiologically Based Pharmacokinetic Models for the Systemic Transport of Trichloroethylene
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 1118140303
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Summary : Three physiologically based pharmacokinetic (PBPK) models for thesystemic transport of inhaled trichloroethylene (TCE) are presented. The major focus ofthese modeling efforts is the disposition of TCE in the adiposetissue, where TCE is known to accumulate. Adipose tissue is highly heterogeneous, with wide variations in fat cell size, lipid composition, blood ...