Pharmacology in Drug Discovery

Written By Terrence P. Kenakin
Pharmacology in Drug Discovery
  • Publsiher : Academic Press
  • Release : 10 April 2021
  • ISBN : 0123848563
  • Pages : 247 pages
  • Rating : /5 from reviews
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Download or read book entitled Pharmacology in Drug Discovery by author: Terrence P. Kenakin which was release on 10 April 2021 and published by Academic Press with total page 247 pages . This book available in PDF, EPUB and Kindle Format. Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material. Enables the reader to interpret drug dose-response data and make mechanistic inferences at the molecular level Bridges the gap between biochemistry and therapeutic medicine Chapters include key topics such as drug affinity and efficacy, enzymes as drug targets, in vivo pharmacology, safety pharmacology, and more

Pharmacology in Drug Discovery

Pharmacology in Drug Discovery
  • Author : Terrence P. Kenakin
  • Publisher : Academic Press
  • Release Date : 2012
  • Total pages : 247
  • ISBN : 0123848563
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Summary : Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can ...

Translational Medicine

Translational Medicine
  • Author : Robert A. Meyers
  • Publisher : John Wiley & Sons
  • Release Date : 2018-07-16
  • Total pages : 1064
  • ISBN : 0123848563
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Summary : This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification ...

Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2016-10-21
  • Total pages : 350
  • ISBN : 0123848563
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Summary : Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book ...

Drug Discovery and Evaluation Methods in Clinical Pharmacology

Drug Discovery and Evaluation  Methods in Clinical Pharmacology
  • Author : H.Gerhard Vogel,Jochen Maas,Alexander Gebauer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-15
  • Total pages : 564
  • ISBN : 0123848563
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Summary : Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these ...

Pharmacology for Chemists

Pharmacology for Chemists
  • Author : Raymond Hill,Terry Kenakin,Tom Blackburn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-30
  • Total pages : 524
  • ISBN : 0123848563
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Summary : Read online Pharmacology for Chemists written by Raymond Hill,Terry Kenakin,Tom Blackburn, published by Royal Society of Chemistry which was released on 2017-10-30. Download full Pharmacology for Chemists Books now! Available in PDF, ePub and Kindle....

Toxins in Drug Discovery and Pharmacology

Toxins in Drug Discovery and Pharmacology
  • Author : Steve Peigneur
  • Publisher : MDPI
  • Release Date : 2018-05-04
  • Total pages : 316
  • ISBN : 0123848563
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Summary : This book is a printed edition of the Special Issue "Toxins in Drug Discovery and Pharmacology" that was published in Toxins...

Drug Discovery and Evaluation

Drug Discovery and Evaluation
  • Author : Hans G. Vogel,Wolfgang H. Vogel
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-17
  • Total pages : 759
  • ISBN : 0123848563
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Summary : This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the ...

Molecular Pharmacology

Molecular Pharmacology
  • Author : John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam
  • Publisher : John Wiley & Sons
  • Release Date : 2012-11-30
  • Total pages : 424
  • ISBN : 0123848563
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Summary : This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of ...

Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery
  • Author : Bhushan Patwardhan,Rathnam Chaguturu
  • Publisher : Academic Press
  • Release Date : 2016-10-03
  • Total pages : 480
  • ISBN : 0123848563
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Summary : Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis ...

Drug Discovery Development

Drug Discovery   Development
  • Author : Bhushan Patwardhan
  • Publisher : New India Publishing
  • Release Date : 2007
  • Total pages : 362
  • ISBN : 0123848563
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Summary : While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have ...

Quantitative Molecular Pharmacology and Informatics in Drug Discovery

Quantitative Molecular Pharmacology and Informatics in Drug Discovery
  • Author : Michael Lutz,Terry Kenakin
  • Publisher : John Wiley & Sons
  • Release Date : 2000-01-10
  • Total pages : 428
  • ISBN : 0123848563
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Summary : Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the ...

Drug Discovery and Evaluation Methods in Clinical Pharmacology

Drug Discovery and Evaluation  Methods in Clinical Pharmacology
  • Author : Franz J. Hock,Michael R. Gralinski
  • Publisher : Springer
  • Release Date : 2020-09-01
  • Total pages : 1169
  • ISBN : 0123848563
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Summary : This is the second edition of a well-received book in the series “Drug Discovery and Evaluation” The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The ...

The Science and Business of Drug Discovery

The Science and Business of Drug Discovery
  • Author : Edward D. Zanders
  • Publisher : Springer Nature
  • Release Date : 2020-12-11
  • Total pages : 402
  • ISBN : 0123848563
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Summary : The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting ...

Early Drug Development 2 Volume Set

Early Drug Development  2 Volume Set
  • Author : Fabrizio Giordanetto
  • Publisher : John Wiley & Sons
  • Release Date : 2018-12-10
  • Total pages : 816
  • ISBN : 0123848563
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Summary : This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early ...

Drug Discovery and Evaluation

Drug Discovery and Evaluation
  • Author : H. Gerhard Vogel
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-01
  • Total pages : 889
  • ISBN : 0123848563
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Summary : This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process....