Patient Derived Tumor Xenograft Models

Written By Rajesh Uthamanthil
Patient Derived Tumor Xenograft Models
  • Publsiher : Academic Press
  • Release : 13 October 2016
  • ISBN : 0128040610
  • Pages : 486 pages
  • Rating : /5 from reviews
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Download or read book entitled Patient Derived Tumor Xenograft Models by author: Rajesh Uthamanthil which was release on 13 October 2016 and published by Academic Press with total page 486 pages . This book available in PDF, EPUB and Kindle Format. Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Patient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models
  • Author : Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina
  • Publisher : Academic Press
  • Release Date : 2016-10-13
  • Total pages : 486
  • ISBN : 0128040610
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Summary : Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing ...

Patient Derived Xenograft Models of Human Cancer

Patient Derived Xenograft Models of Human Cancer
  • Author : Yuzhuo Wang,Dong Lin,Peter W. Gout
  • Publisher : Springer
  • Release Date : 2017-06-29
  • Total pages : 204
  • ISBN : 0128040610
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Summary : This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of ...

Patient Derived Mouse Models of Cancer

Patient Derived Mouse Models of Cancer
  • Author : Robert M. Hoffman
  • Publisher : Springer
  • Release Date : 2017-08-31
  • Total pages : 296
  • ISBN : 0128040610
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Summary : This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently ...

Patient derived Organoid Systems for the Study of Castrate resistant Metastatic Prostate Cancer

Patient derived Organoid Systems for the Study of Castrate resistant Metastatic Prostate Cancer
  • Author : William Zhu
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 15
  • ISBN : 0128040610
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Summary : Bone metastases of prostate cancer continue to elude effective clinical management world-wide. A newly developed xenograft model, PCSD1, is a pre-clinical therapeutic development and testing platform to understand the mechanisms of resistance to androgen deprivation therapy of bone metastatic prostate cancer. Prostate cancer is a heterogeneous disease for which it ...

Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient derived Xenograft Models of Colorectal Cancer

Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient derived Xenograft Models of Colorectal Cancer
  • Author : Marielle Chiron
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 9
  • ISBN : 0128040610
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Summary : Read online Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient derived Xenograft Models of Colorectal Cancer written by Marielle Chiron, published by which was released on 2014. Download full Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient derived Xenograft Models of Colorectal Cancer Books now! Available in PDF, ePub ...

Molecular and Preclinical Evaluation of Patient derived Orthotopic Xenograft Models of Pediatric Brain Tumors

Molecular and Preclinical Evaluation of Patient derived Orthotopic Xenograft Models of Pediatric Brain Tumors
  • Author : Sebastian Brabetz
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0128040610
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Summary : Read online Molecular and Preclinical Evaluation of Patient derived Orthotopic Xenograft Models of Pediatric Brain Tumors written by Sebastian Brabetz, published by which was released on 2018. Download full Molecular and Preclinical Evaluation of Patient derived Orthotopic Xenograft Models of Pediatric Brain Tumors Books now! Available in PDF, ePub and Kindle....

Development of a Patient derived Xenograft Model of Ovarian Cancer to Characterize the Chemotherapy Resistant Population

Development of a Patient derived Xenograft Model of Ovarian Cancer to Characterize the Chemotherapy Resistant Population
  • Author : Zachary Christopher Dobbin
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 131
  • ISBN : 0128040610
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Summary : Ovarian cancer while the second most common gynecologic malignancy is the most commons cause of death due to a gynecologic malignancy and the fifth most common cause of death to cancer in women. In 2014, there will be an expected 21,980 cases and 14,270 deaths. Unfortunately, the five-year survival for ovarian cancer is ...

Colorectal Cancer Patient derived Xenograft PDX Models as Platform for Drug Screening Molecular and Response Analysis

Colorectal Cancer Patient derived Xenograft  PDX  Models as Platform for Drug Screening  Molecular and Response Analysis
  • Author : Maria Rivera
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 212
  • ISBN : 0128040610
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Summary : Read online Colorectal Cancer Patient derived Xenograft PDX Models as Platform for Drug Screening Molecular and Response Analysis written by Maria Rivera, published by which was released on 2016. Download full Colorectal Cancer Patient derived Xenograft PDX Models as Platform for Drug Screening Molecular and Response Analysis Books now! Available in ...

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release Date : 2019-04-16
  • Total pages : 470
  • ISBN : 0128040610
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Summary : Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on ...

Patient Derived Models of IDH1 Mutant Hypermutated Glioma

Patient Derived Models of IDH1 Mutant  Hypermutated Glioma
  • Author : Lindsey Elise Jones
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 73
  • ISBN : 0128040610
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Summary : Gliomas are a group of central nervous system tumors that are classified based upon histopathological and molecular features. IDH-mutant low-grade gliomas (LGG) are prognostically favorable tumors and are often treated with temozolomide, but can undergo malignant progression via TMZ-induced hypermutation. Cell cultures that faithfully model this genetically distinct and clinically ...

Advances in Epithelial Ovarian Cancer Model Systems Microenvironmental Influences Therapy and Origins

Advances in Epithelial Ovarian Cancer  Model Systems  Microenvironmental Influences  Therapy  and Origins
  • Author : Viive Maarika Howell,Ben Davidson,TIAN-Li WANG,Christina Annunziata
  • Publisher : Frontiers Media SA
  • Release Date : 2016-02-03
  • Total pages : 212
  • ISBN : 0128040610
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Summary : This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles ...

A Novel Approach to Develop Predictive Biomarkers

A Novel Approach to Develop Predictive Biomarkers
  • Author : Paulina Pechańska
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 208
  • ISBN : 0128040610
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Summary : Read online A Novel Approach to Develop Predictive Biomarkers written by Paulina Pechańska, published by which was released on 2014. Download full A Novel Approach to Develop Predictive Biomarkers Books now! Available in PDF, ePub and Kindle....

Chick Chorioallantoic Membrane Model and Precision Cancer Therapy

Chick Chorioallantoic Membrane Model and Precision Cancer Therapy
  • Author : Fuyuhiko Tamanoi
  • Publisher : Academic Press
  • Release Date : 2019-11-12
  • Total pages : 178
  • ISBN : 0128040610
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Summary : Chick Chorioallantoic Membrane Model and Precision Cancer Therapy, Volume 46 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on the history of CAM model development, an overview of various CAM-based cancer models, the chick embryo chorioallantoic membrane as an in vivo experimental ...

Leveraging Protein Evolution to Elucidate Oncogenic Cytokine Signaling Axes and Develop Novel Therapeutics for Highly Lethal Cancers

Leveraging Protein Evolution to Elucidate Oncogenic Cytokine Signaling Axes and Develop Novel Therapeutics for Highly Lethal Cancers
  • Author : César Márquez
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 212
  • ISBN : 0128040610
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Summary : Pro-inflammatory cytokines in the tumor microenvironment (TME) can promote tumor growth, yet their value as therapeutic targets remains underexploited. Monoclonal antibodies have been the most widely used strategy to block ligand-receptor interactions and neutralize biological activity. An alternative approach involves engineering an extracellular fragment of a soluble receptor as a ...

Pharmacokinetics and Biodistribution of 89Zr Df PEG40 Nanoparticles in Xenograft Tumor Models Using Micro PET CT

Pharmacokinetics and Biodistribution of 89Zr Df PEG40 Nanoparticles in Xenograft Tumor Models Using Micro PET CT
  • Author : Guillaume Trusz
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 39
  • ISBN : 0128040610
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Summary : One of the challenges that physicians face is the uncertainty that their therapy of choice will be effective. A reason why therapeutic treatments often fall short in efficacy remains their limited presence and accumulation at the intended site of action. This challenge may be overcome by utilizing non-invasive molecular imaging. ...