Overflow Metabolism

Written By Alexei Vazquez
Overflow Metabolism
  • Publsiher : Academic Press
  • Release : 27 October 2017
  • ISBN : 0128123354
  • Pages : 84 pages
  • Rating : /5 from reviews
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Download or read book entitled Overflow Metabolism by author: Alexei Vazquez which was release on 27 October 2017 and published by Academic Press with total page 84 pages . This book available in PDF, EPUB and Kindle Format. Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

Overflow Metabolism

Overflow Metabolism
  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Release Date : 2017-10-27
  • Total pages : 84
  • ISBN : 0128123354
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Summary : Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients ...

A Metabolic Engineering Approach to Study Overflow Metabolism in Escherichia Coli

A Metabolic Engineering Approach to Study Overflow Metabolism in Escherichia Coli
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 452
  • ISBN : 0128123354
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Summary : Read online A Metabolic Engineering Approach to Study Overflow Metabolism in Escherichia Coli written by , published by which was released on 2005. Download full A Metabolic Engineering Approach to Study Overflow Metabolism in Escherichia Coli Books now! Available in PDF, ePub and Kindle....

The Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli

The Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli
  • Author : Chuankai Cheng
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 45
  • ISBN : 0128123354
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Summary : Overflow metabolism can be explained by a pathway switch behavior in the cell based on the tradeoffs between metabolic efficiency and proteomic efficiency (enzymatic kinetics). This thesis simulates this behavior on the both small-scale and genome-scale model. By sweeping the enzyme kinetics parameters on multiple pathways or reactions, the simulation ...

The Significance of Overflow Metabolism in the Physiology and Growth of Klebsiella Aerogenes

The Significance of Overflow Metabolism in the Physiology and Growth of Klebsiella Aerogenes
  • Author : Oense Martinus Neijssel
  • Publisher : Unknown
  • Release Date : 1976
  • Total pages : 52
  • ISBN : 0128123354
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Summary : Read online The Significance of Overflow Metabolism in the Physiology and Growth of Klebsiella Aerogenes written by Oense Martinus Neijssel, published by which was released on 1976. Download full The Significance of Overflow Metabolism in the Physiology and Growth of Klebsiella Aerogenes Books now! Available in PDF, ePub and Kindle....

The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading

The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 212
  • ISBN : 0128123354
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Summary : Background: Clostridium thermocellum is a model thermophilic organism for the production of biofuels from lignocellulosic substrates. The majority of publications studying the physiology of this organism use substrate concentrations of ≤10 g/L. However, industrially relevant concentrations of substrate start at 100 g/L carbohydrate, which corresponds to approximately 150 g/L solids. ...

The significance of overflow metabolism in the physiology and g

The significance of overflow metabolism in the physiology and g
  • Author : Oense Martinus Neijssel
  • Publisher : Unknown
  • Release Date : 1976
  • Total pages : 212
  • ISBN : 0128123354
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Summary : Read online The significance of overflow metabolism in the physiology and g written by Oense Martinus Neijssel, published by which was released on 1976. Download full The significance of overflow metabolism in the physiology and g Books now! Available in PDF, ePub and Kindle....

The Journal of General Physiology

The Journal of General Physiology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1948
  • Total pages : 212
  • ISBN : 0128123354
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Summary : Read online The Journal of General Physiology written by , published by which was released on 1948. Download full The Journal of General Physiology Books now! Available in PDF, ePub and Kindle....

Insect Plant Interactions

Insect Plant Interactions
  • Author : Elizabeth A. Bernays
  • Publisher : CRC Press
  • Release Date : 2019-10-01
  • Total pages : 176
  • ISBN : 0128123354
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Summary : First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in ...

The Effect of Cations on Microbial Metabolism and Growth Energetics

The Effect of Cations on Microbial Metabolism and Growth Energetics
  • Author : Ed T. Buurman
  • Publisher : Unknown
  • Release Date : 1991
  • Total pages : 109
  • ISBN : 0128123354
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Summary : Read online The Effect of Cations on Microbial Metabolism and Growth Energetics written by Ed T. Buurman, published by which was released on 1991. Download full The Effect of Cations on Microbial Metabolism and Growth Energetics Books now! Available in PDF, ePub and Kindle....

Quantitative Aspects of Growth and Metabolism of Microorganisms

Quantitative Aspects of Growth and Metabolism of Microorganisms
  • Author : A.H. Stouthamer
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 252
  • ISBN : 0128123354
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Summary : Application of recent advances, such as non-equilibrium thermodynamics, the maintenance concept and the material balancing method, to the description, of microbial growth has suggested new experimental approaches which have yielded a wealth of data. These data have been used to develop mathematical models of microbial growth and metabolism, and the ...

Physiological Stress Responses in Bioprocesses

Physiological Stress Responses in Bioprocesses
  • Author : Sven-Olof Enfors,Thomas Egli
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-05-06
  • Total pages : 244
  • ISBN : 0128123354
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Summary : This review series covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http://link.springer.de/series/abe/...

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production
  • Author : Kazuyuki Shimizu
  • Publisher : CRC Press
  • Release Date : 2017-07-12
  • Total pages : 325
  • ISBN : 0128123354
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Summary : The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of ...

Metabolism and Bacterial Pathogenesis

Metabolism and Bacterial Pathogenesis
  • Author : Tyrrell Conway,Paul S. Cohen
  • Publisher : John Wiley & Sons
  • Release Date : 2020-07-24
  • Total pages : 382
  • ISBN : 0128123354
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Summary : Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific ...

Basic Biotechnology

Basic Biotechnology
  • Author : Colin Ratledge,Bjorn Kristiansen
  • Publisher : Cambridge University Press
  • Release Date : 2006-05-25
  • Total pages : 666
  • ISBN : 0128123354
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Summary : Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined ...

The Metabolic Pathway Engineering Handbook

The Metabolic Pathway Engineering Handbook
  • Author : Christina Smolke
  • Publisher : CRC Press
  • Release Date : 2009-07-28
  • Total pages : 678
  • ISBN : 0128123354
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Summary : This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction...