Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Written By Anthony Faber
Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC
  • Publsiher : Academic Press
  • Release : 15 March 2021
  • ISBN : 9780128228333
  • Pages : 250 pages
  • Rating : /5 from reviews
GET THIS BOOKOvercoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC


Download or read book entitled Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC by author: Anthony Faber which was release on 15 March 2021 and published by Academic Press with total page 250 pages . This book available in PDF, EPUB and Kindle Format. Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC
  • Author : Anthony Faber
  • Publisher : Academic Press
  • Release Date : 2021-03-15
  • Total pages : 250
  • ISBN : 9780128228333
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Summary : Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is ...

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,Sanjay J. Surana
  • Publisher : Elsevier
  • Release Date : 2018-11-27
  • Total pages : 208
  • ISBN : 9780128228333
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Summary : Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation ...

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma
  • Author : Caroline Amalia Nebhan
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 145
  • ISBN : 9780128228333
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Summary : Read online Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma written by Caroline Amalia Nebhan, published by which was released on 2014. Download full Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma Books now! Available in PDF, ePub and Kindle....

Targeted Therapies in Lung Cancer Management Strategies for Nurses and Practitioners

Targeted Therapies in Lung Cancer  Management Strategies for Nurses and Practitioners
  • Author : Marianne Davies,Beth Eaby-Sandy
  • Publisher : Springer
  • Release Date : 2019-07-16
  • Total pages : 120
  • ISBN : 9780128228333
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Summary : This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In ...

Exploitation and Mechanistic Validation of Drug combination Strategies to Overcome EGFR inhibitor Resistance in NSCLC Cells

Exploitation and Mechanistic Validation of Drug combination Strategies to Overcome EGFR inhibitor Resistance in NSCLC Cells
  • Author : Yu-Chieh Wang
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 9780128228333
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Summary : Abstract: Pre-existing and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). In this dissertation research work, the in vitro/in vivo efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived antitumor ...

Lung Cancer and Personalized Medicine Novel Therapies and Clinical Management

Lung Cancer and Personalized Medicine  Novel Therapies and Clinical Management
  • Author : Aamir Ahmad,Shirish M. Gadgeel
  • Publisher : Springer
  • Release Date : 2015-12-24
  • Total pages : 231
  • ISBN : 9780128228333
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Summary : This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and ...

Current Applications for Overcoming Resistance to Targeted Therapies

Current Applications for Overcoming Resistance to Targeted Therapies
  • Author : Myron R. Szewczuk,Bessi Qorri,Manpreet Sambi
  • Publisher : Springer
  • Release Date : 2019-07-15
  • Total pages : 320
  • ISBN : 9780128228333
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Summary : Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the ...

AACR 2016 Abstracts 1 2696

AACR 2016  Abstracts 1 2696
  • Author : American Association for Cancer Research (AACR)
  • Publisher : CTI Meeting Technology
  • Release Date : 2016-03-28
  • Total pages : 212
  • ISBN : 9780128228333
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Summary : The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are ...

IASLC Thoracic Oncology E Book

IASLC Thoracic Oncology E Book
  • Author : Harvey Pass,David Ball,Giorgio Scagliotti
  • Publisher : Elsevier Health Sciences
  • Release Date : 2017-04-21
  • Total pages : 960
  • ISBN : 9780128228333
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Summary : Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today’s best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to ...

Cancer Research

Cancer Research
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 9780128228333
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Summary : Read online Cancer Research written by , published by which was released on 2008. Download full Cancer Research Books now! Available in PDF, ePub and Kindle....

The Treatment of Metastatic Non small Cell Lung Cancer NSCLC in New Era of Personalised Medicine

The Treatment of Metastatic Non small Cell Lung Cancer  NSCLC  in New Era of Personalised Medicine
  • Author : Vera Hirsh,Barbara Melosky
  • Publisher : Frontiers Media SA
  • Release Date : 2015-10-20
  • Total pages : 212
  • ISBN : 9780128228333
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Summary : Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common form of lung cancer, accounting for approximately 87% of cases. Systemic ...

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
  • Author : Yuichi Takiguchi
  • Publisher : Springer
  • Release Date : 2017-01-24
  • Total pages : 327
  • ISBN : 9780128228333
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Summary : This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also ...

Oncology

Oncology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 9780128228333
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Summary : Read online Oncology written by , published by which was released on 2008. Download full Oncology Books now! Available in PDF, ePub and Kindle....

At 101 Enhances Gefitinib Sensitivity in Non Small Cell Lung Cancer with EGFR T790M Mutations

At 101 Enhances Gefitinib Sensitivity in Non Small Cell Lung Cancer with EGFR T790M Mutations
  • Author : Cape Town Cape Town Press
  • Publisher : Unknown
  • Release Date : 2017-01-03
  • Total pages : 36
  • ISBN : 9780128228333
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Summary : Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard care of patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC), development of acquired resistance is inevitable. A secondary mutation of threonine 790 (T790M) is associated with approximately half of the cases of acquired resistance. Strategies ...

American Journal of Respiratory and Critical Care Medicine

American Journal of Respiratory and Critical Care Medicine
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 9780128228333
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Summary : Read online American Journal of Respiratory and Critical Care Medicine written by , published by which was released on 2007. Download full American Journal of Respiratory and Critical Care Medicine Books now! Available in PDF, ePub and Kindle....