Novel Designs of Early Phase Trials for Cancer Therapeutics

Written By Shivaani Kummar
Novel Designs of Early Phase Trials for Cancer Therapeutics
  • Publsiher : Academic Press
  • Release : 22 May 2018
  • ISBN : 0128125705
  • Pages : 234 pages
  • Rating : /5 from reviews
GET THIS BOOKNovel Designs of Early Phase Trials for Cancer Therapeutics


Download or read book entitled Novel Designs of Early Phase Trials for Cancer Therapeutics by author: Shivaani Kummar which was release on 22 May 2018 and published by Academic Press with total page 234 pages . This book available in PDF, EPUB and Kindle Format. Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development

Novel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics
  • Author : Shivaani Kummar,Chris Takimoto
  • Publisher : Academic Press
  • Release Date : 2018-05-22
  • Total pages : 234
  • ISBN : 0128125705
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Summary : Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses ...

Statistical Approaches in Oncology Clinical Development

Statistical Approaches in Oncology Clinical Development
  • Author : Satrajit Roychoudhury,Soumi Lahiri
  • Publisher : CRC Press
  • Release Date : 2018-12-07
  • Total pages : 220
  • ISBN : 0128125705
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Summary : Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview of statistical considerations in oncology clinical trials, both early and late phase of development. It illustrates how novel statistical methods can enrich the design and analysis of modern oncology trials. The authors include many relevant real ...

Dose Finding Designs for Early Phase Cancer Clinical Trials

Dose Finding Designs for Early Phase Cancer Clinical Trials
  • Author : Takashi Daimon,Akihiro Hirakawa,Shigeyuki Matsui
  • Publisher : Springer
  • Release Date : 2019-05-21
  • Total pages : 133
  • ISBN : 0128125705
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Summary : This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide ...

Phase I Cancer Clinical Trials

Phase I Cancer Clinical Trials
  • Author : Chris Twelves,Marc E. Buyse
  • Publisher : Oxford University Press, USA
  • Release Date : 2014-06-01
  • Total pages : 368
  • ISBN : 0128125705
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Summary : Preceded by Phase I cancer clinical trials: a practical guide / Elizabeth A. Eisenhauer, Christopher Twelves, Marc Buyse. 1st ed. 2006....

Oncology Clinical Trials

Oncology Clinical Trials
  • Author : Susan Halabi, PhD,Wm. Kevin Kelly, DO
  • Publisher : Demos Medical Publishing
  • Release Date : 2009-12-22
  • Total pages : 168
  • ISBN : 0128125705
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Summary : Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the ...

A Practical Guide to Designing Phase II Trials in Oncology

A Practical Guide to Designing Phase II Trials in Oncology
  • Author : Sarah R. Brown,Walter M. Gregory,Christopher J. Twelves,Julia M. Brown
  • Publisher : John Wiley & Sons
  • Release Date : 2014-03-28
  • Total pages : 256
  • ISBN : 0128125705
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Summary : How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase ...

Biomarkers of the Tumor Microenvironment

Biomarkers of the Tumor Microenvironment
  • Author : Lars A. Akslen,Randolph S. Watnick
  • Publisher : Springer
  • Release Date : 2017-08-02
  • Total pages : 534
  • ISBN : 0128125705
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Summary : This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in ...

Blood and Marrow Transplantation Long Term Management

Blood and Marrow Transplantation Long Term Management
  • Author : Bipin N. Savani,Andre Tichelli
  • Publisher : John Wiley & Sons
  • Release Date : 2021-03-02
  • Total pages : 464
  • ISBN : 0128125705
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Summary : Hematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. ...

Textbook of Gastrointestinal Oncology

Textbook of Gastrointestinal Oncology
  • Author : Suayib Yalcin,Philip A. Philip
  • Publisher : Springer Nature
  • Release Date : 2019-09-05
  • Total pages : 716
  • ISBN : 0128125705
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Summary : This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful ...

The American Cancer Society s Principles of Oncology

The American Cancer Society s Principles of Oncology
  • Author : The American Cancer Society
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-13
  • Total pages : 472
  • ISBN : 0128125705
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Summary : Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners is a comprehensive reference covering the diagnosis of cancer, and a range of related issues that are key to a multidisciplinary approach to cancer and critical to cancer control and may be ...

Oncology Clinical Trials

Oncology Clinical Trials
  • Author : William Kevin Kelly, DO,Susan Halabi, PhD
  • Publisher : Springer Publishing Company
  • Release Date : 2018-03-28
  • Total pages : 600
  • ISBN : 0128125705
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Summary : The second edition of Oncology Clinical Trials has been thoroughly revised and updated and now contains the latest designs and methods of conducting and analyzing cancer clinical trials in the era of precision medicine with biologic agents—including trials investigating the safety and efficacy of targeted therapies, immunotherapies, and combination ...

Early Phase Cancer Immunotherapy

Early Phase Cancer Immunotherapy
  • Author : Sandip Pravin Patel,Razelle Kurzrock
  • Publisher : Springer
  • Release Date : 2017-11-03
  • Total pages : 331
  • ISBN : 0128125705
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Summary : This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy....

Phase I Cancer Clinical Trials

Phase I Cancer Clinical Trials
  • Author : Elizabeth A. Eisenhauer,Christopher Twelves,Marc Buyse
  • Publisher : Oxford University Press
  • Release Date : 2015-03-20
  • Total pages : 352
  • ISBN : 0128125705
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Summary : Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies ...

Designs for Clinical Trials

Designs for Clinical Trials
  • Author : David Harrington
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-09
  • Total pages : 206
  • ISBN : 0128125705
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Summary : This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, the design of studies in which missing data is anticipated. Each chapter will be written by an expert conducting research in the topic ...

Handbook of Brain Tumor Chemotherapy Molecular Therapeutics and Immunotherapy

Handbook of Brain Tumor Chemotherapy  Molecular Therapeutics  and Immunotherapy
  • Author : Herbert B. Newton
  • Publisher : Academic Press
  • Release Date : 2018-03-28
  • Total pages : 848
  • ISBN : 0128125705
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Summary : Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular ...