Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

Written By Carrie Markgraf
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
  • Publsiher : Academic Press
  • Release : 14 July 2015
  • ISBN : 0124202160
  • Pages : 320 pages
  • Rating : /5 from reviews
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Download or read book entitled Nonclinical Assessment of Abuse Potential for New Pharmaceuticals by author: Carrie Markgraf which was release on 14 July 2015 and published by Academic Press with total page 320 pages . This book available in PDF, EPUB and Kindle Format. Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
  • Author : Carrie Markgraf,Thomas Hudzik,David Compton
  • Publisher : Academic Press
  • Release Date : 2015-07-14
  • Total pages : 320
  • ISBN : 0124202160
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Summary : Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples ...

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2016-11-03
  • Total pages : 986
  • ISBN : 0124202160
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Summary : A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem ...

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A Comprehensive Guide to Toxicology in Preclinical Drug Development
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  • Publisher : Academic Press
  • Release Date : 2012-10-18
  • Total pages : 1024
  • ISBN : 0124202160
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Summary : A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide ...

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Stem Cells in Toxicology and Medicine
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  • Publisher : John Wiley & Sons
  • Release Date : 2016-10-13
  • Total pages : 560
  • ISBN : 0124202160
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Summary : A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A ...

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  • Publisher : Oxford University Press, USA
  • Release Date : 2020-10
  • Total pages : 212
  • ISBN : 0124202160
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Summary : "Over the last few years there has been an increased interest in identification and treatment of substance use disorders, due at least in part to the widespread drug overdose epidemic. Clinicians and the lay public have gained a greater understanding of the need for treatment of substance use disorders and ...

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

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  • Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
  • Publisher : Academic Press
  • Release Date : 2015-03-13
  • Total pages : 716
  • ISBN : 0124202160
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Summary : The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, ...

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  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • Total pages : 1054
  • ISBN : 0124202160
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Summary : This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, ...

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  • Publisher : CRC Press
  • Release Date : 2019-11-21
  • Total pages : 668
  • ISBN : 0124202160
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Summary : Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of ...

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  • Author : Sarah E. Boslaugh
  • Publisher : SAGE Publications
  • Release Date : 2015-09-15
  • Total pages : 1888
  • ISBN : 0124202160
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Summary : The SAGE Encyclopedia of Pharmacology and Society explores the social and policy sides of the pharmaceutical industry and its pervasive influence in society. While many technical STM works explore the chemistry and biology of pharmacology and an equally large number of clinically oriented works focus on use of illegal drugs, ...

Advanced Issue Resolution in Safety Pharmacology

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  • Author : Mary Jeanne Kallman,Michael Pugsley
  • Publisher : Academic Press
  • Release Date : 2018-09-05
  • Total pages : 360
  • ISBN : 0124202160
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Summary : Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it ...

Testing for Abuse Liability of Drugs in Humans

Testing for Abuse Liability of Drugs in Humans
  • Author : Marian W. Fischman,Nancy K. Mello
  • Publisher : Unknown
  • Release Date : 1989
  • Total pages : 398
  • ISBN : 0124202160
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Summary : Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and ...

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  • Publisher : John Wiley & Sons
  • Release Date : 2016-04-18
  • Total pages : 584
  • ISBN : 0124202160
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Summary : As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers ...

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Principles of Safety Pharmacology
  • Author : Michael K. Pugsley,Michael J Curtis
  • Publisher : Springer
  • Release Date : 2015-06-19
  • Total pages : 481
  • ISBN : 0124202160
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Summary : This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current ...

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  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release Date : 2009-02-24
  • Total pages : 432
  • ISBN : 0124202160
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Summary : Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory ...

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  • Publisher : Springer
  • Release Date : 2016-03-30
  • Total pages : 341
  • ISBN : 0124202160
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Summary : This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug ...