NK Cell Based Cancer Immunotherapy

Written By Francisco Borrego
NK Cell Based Cancer Immunotherapy
  • Publsiher : Frontiers Media SA
  • Release : 08 September 2016
  • ISBN : 2889199347
  • Pages : pages
  • Rating : /5 from reviews
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Download or read book entitled NK Cell Based Cancer Immunotherapy by author: Francisco Borrego which was release on 08 September 2016 and published by Frontiers Media SA with total page pages . This book available in PDF, EPUB and Kindle Format. Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

NK Cell Based Cancer Immunotherapy

NK Cell Based Cancer Immunotherapy
  • Author : Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona
  • Publisher : Frontiers Media SA
  • Release Date : 2016-09-08
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC ...

Natural Killer Cells

Natural Killer Cells
  • Author : Jacques Zimmer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-01-12
  • Total pages : 428
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. ...

Cancer Immunotherapy

Cancer Immunotherapy
  • Author : Sarah S. Donatelli,Julie Y. Djeu
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Total pages : 684
  • ISBN : 2889199347
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Summary : Natural Killer (NK) cells are a unique subset of lymphocytes genetically programmed to locate and destroy cellular malignancies. They accomplish this through unique cell surface receptors that, upon contacting a target cell, transmit either inhibitory or activating intracellular signals, ultimately determining whether the target cell will be killed or spared. ...

NKT Cells in Cancer Immunotherapy 2nd Edition

NKT Cells in Cancer Immunotherapy  2nd Edition
  • Author : Tonya J. Webb,Paolo Dellabona,Weiming Yuan,Everett Meyer
  • Publisher : Frontiers Media SA
  • Release Date : 2020-11-20
  • Total pages : 178
  • ISBN : 2889199347
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Summary : Read online NKT Cells in Cancer Immunotherapy 2nd Edition written by Tonya J. Webb,Paolo Dellabona,Weiming Yuan,Everett Meyer, published by Frontiers Media SA which was released on 2020-11-20. Download full NKT Cells in Cancer Immunotherapy 2nd Edition Books now! Available in PDF, ePub and Kindle....

NK Cells in Cancer Immunotherapy Successes and Challenges

NK Cells in Cancer Immunotherapy  Successes and Challenges
  • Author : Anahid Jewett
  • Publisher : Academic Press
  • Release Date : 2021-03-15
  • Total pages : 350
  • ISBN : 2889199347
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Summary : NK cells in cancer immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies focusing on NK cells to allow the best and precise combination treatment to be offered to cancer patients. It provides existing background knowledge in the field of immunotherapy and discusses the future areas of research required to ...

NK Cells in Cancer Immunotherapy

NK Cells in Cancer Immunotherapy
  • Author : Lynda Addou-Klouche
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer. NK cells' activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. Opposite signals delivered by ...

Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy
  • Author : Benjamin Bonavida,Anahid Jewett
  • Publisher : Academic Press
  • Release Date : 2021-06-25
  • Total pages : 538
  • ISBN : 2889199347
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Summary : Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various ...

Expansion of Highly Cytotoxic Human Natural Killer Cells by Osteoclast for Cancer Immunotherapy

Expansion of Highly Cytotoxic Human Natural Killer Cells by Osteoclast for Cancer Immunotherapy
  • Author : So-Hyun Park
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 105
  • ISBN : 2889199347
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Summary : Natural Killer (NK) cells have a crucial role in immune surveillance against a variety of infectious microorganisms and tumors. NK cells are known to mediate direct cytotoxicity as well as antibody dependent cellular cytotoxicity (ADCC) against a variety of tumor cells. Also, they are known to regulate the functions of ...

Lymphocytes in Immunotherapy of Cancer

Lymphocytes in Immunotherapy of Cancer
  • Author : Paul Koldovsky,Ursula Koldovsky,Lutwin Beck,Karl-Heinz Vosteen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 100
  • ISBN : 2889199347
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Summary : In the past, research in cancer immunology has produced informa tion important for other medical disciplines. It helped, for example, in formulating the laws of immunogenetics and in achieving a better understanding of the mechanism governing the fate of allotrans planted tissue. Cancer has often been considered a foreign body, ...

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer
  • Author : Loredana Cifaldi,Daniel Olive,James Di Santo
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-31
  • Total pages : 212
  • ISBN : 2889199347
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Summary : In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing ...

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia
  • Author : Eva Lion,Evelien Smits,Viggo Van Tendeloo
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2012-07
  • Total pages : 260
  • ISBN : 2889199347
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Summary : The ultimate goal of tumor immunotherapy is the eradication of tumor cells by the immune system. Both innate and adaptive immune responses can contribute to the elimination of tumor cells, with natural killer (NK) cells and T lymphocytes as pivotal players, respectively. Dendritic cells (DC) are the most professional antigen-presenting ...

Cancer Immunotherapy and Biological Cancer Treatments

Cancer Immunotherapy and Biological Cancer Treatments
  • Author : Hilal Arnouk
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-11-13
  • Total pages : 112
  • ISBN : 2889199347
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Summary : In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or ...

Natural Killer Cells the Future of Cancer Immunotherapy

Natural Killer Cells  the Future of Cancer Immunotherapy
  • Author : Priyanka Senthil
  • Publisher : Unknown
  • Release Date : 2020-04-20
  • Total pages : 53
  • ISBN : 2889199347
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Summary : Cellular therapeutics is an emerging field with significant advances in the engineering of immune effector cells that play a revolutionary role in treatment for cancer. Up until now, most immunomodulatory strategies focus on enhancing T cells, which are lymphocyte immune cells that are important for cell-mediated immunity to fight pathogens ...

Clinical Applications of Natural Killer Cells

Clinical Applications of Natural Killer Cells
  • Author : Yui Harada
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells are an essential component of the innate immune system, and they play a crucial role in immunity against malignancies. Recent advances in our understanding of NK cell biology have paved the way for new therapeutic strategies based on NK cells for the treatment of various cancers. ...

Oncoimmunology

Oncoimmunology
  • Author : Laurence Zitvogel,Guido Kroemer
  • Publisher : Springer
  • Release Date : 2017-12-13
  • Total pages : 724
  • ISBN : 2889199347
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Summary : In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to ...