NK Cell Based Cancer Immunotherapy

Written By Francisco Borrego
NK Cell Based Cancer Immunotherapy
  • Publsiher : Frontiers Media SA
  • Release : 08 September 2016
  • ISBN : 2889199347
  • Pages : pages
  • Rating : /5 from reviews
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Download or read book entitled NK Cell Based Cancer Immunotherapy by author: Francisco Borrego which was release on 08 September 2016 and published by Frontiers Media SA with total page pages . This book available in PDF, EPUB and Kindle Format. Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

NK Cell Based Cancer Immunotherapy

NK Cell Based Cancer Immunotherapy
  • Author : Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona
  • Publisher : Frontiers Media SA
  • Release Date : 2016-09-08
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC ...

NK Cells in Cancer Immunotherapy Successes and Challenges

NK Cells in Cancer Immunotherapy  Successes and Challenges
  • Author : Anahid Jewett
  • Publisher : Academic Press
  • Release Date : 2021-03-15
  • Total pages : 350
  • ISBN : 2889199347
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Summary : NK cells in cancer immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies focusing on NK cells to allow the best and precise combination treatment to be offered to cancer patients. It provides existing background knowledge in the field of immunotherapy and discusses the future areas of research required to ...

NK Cells in Cancer Immunotherapy

NK Cells in Cancer Immunotherapy
  • Author : Lynda Addou-Klouche
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer. NK cells' activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. Opposite signals delivered by ...

The Memory Activation of NK Cells New Methods in Cancer Immunotherapy

The Memory Activation of NK Cells  New Methods in Cancer Immunotherapy
  • Author : Gheorghita Isvoranu
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Cancer remains a main cause of mortality, despite the research efforts to unravel molecular mechanisms and for developing personalized targeted therapies with acceptable side effects. In cancer, both players, the aggressor (tumor cells) and the endogenous defenders (immune cells), are key therapeutic targets. Immunotherapy is nowadays considered the fourth therapeutical ...

Tumor Immunology and Immunotherapy

Tumor Immunology and Immunotherapy
  • Author : Robert C. Rees
  • Publisher : Oxford University Press, USA
  • Release Date : 2014-05-20
  • Total pages : 442
  • ISBN : 2889199347
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Summary : Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting ...

Natural Killer Cells

Natural Killer Cells
  • Author : Jacques Zimmer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-01-12
  • Total pages : 428
  • ISBN : 2889199347
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Summary : Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. ...

The Natural Killer Cell Interactome in the Tumor Microenvironment Basic Concepts and Clinical Application

The Natural Killer Cell Interactome in the Tumor Microenvironment  Basic Concepts and Clinical Application
  • Author : Martin Villalba,Régis Thierry Costello,Julian Pardo,Alberto Anel
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-02
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Read online The Natural Killer Cell Interactome in the Tumor Microenvironment Basic Concepts and Clinical Application written by Martin Villalba,Régis Thierry Costello,Julian Pardo,Alberto Anel, published by Frontiers Media SA which was released on 2020-07-02. Download full The Natural Killer Cell Interactome in the Tumor Microenvironment ...

Cancer Immunology

Cancer Immunology
  • Author : Nima Rezaei
  • Publisher : Springer
  • Release Date : 2014-12-29
  • Total pages : 485
  • ISBN : 2889199347
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Summary : This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for ...

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1994
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Read online Biomedical Index to PHS supported Research written by , published by which was released on 1994. Download full Biomedical Index to PHS supported Research Books now! Available in PDF, ePub and Kindle....

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer
  • Author : Loredana Cifaldi,Daniel Olive,James Di Santo
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-31
  • Total pages : 212
  • ISBN : 2889199347
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Summary : In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing ...

Natural Killer T cells

Natural Killer T cells
  • Author : Masaki Terabe,Jay A. Berzofsky
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-09-22
  • Total pages : 208
  • ISBN : 2889199347
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Summary : This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells....

Cancer Immunology Immunotherapy

Cancer Immunology  Immunotherapy
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1991
  • Total pages : 212
  • ISBN : 2889199347
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Summary : Read online Cancer Immunology Immunotherapy written by , published by which was released on 1991. Download full Cancer Immunology Immunotherapy Books now! Available in PDF, ePub and Kindle....

Cancer Immunotherapy

Cancer Immunotherapy
  • Author : George C. Prendergast,Elizabeth M. Jaffee
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Total pages : 428
  • ISBN : 2889199347
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Summary : There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly ...

Cancer Immunotherapy and Biological Cancer Treatments

Cancer Immunotherapy and Biological Cancer Treatments
  • Author : Hilal Arnouk
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-11-13
  • Total pages : 112
  • ISBN : 2889199347
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Summary : In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or ...

Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy
  • Author : Glenn Dranoff
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-11
  • Total pages : 306
  • ISBN : 2889199347
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Summary : The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an ...