Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury

Written By Arthur Liesz
Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury
  • Publsiher : Frontiers Media SA
  • Release : 13 November 2015
  • ISBN : 2889196917
  • Pages : 284 pages
  • Rating : /5 from reviews
GET THIS BOOKMechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury


Download or read book entitled Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury by author: Arthur Liesz which was release on 13 November 2015 and published by Frontiers Media SA with total page 284 pages . This book available in PDF, EPUB and Kindle Format. Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.

Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury

Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury
  • Author : Arthur Liesz,Christoph Kleinschnitz
  • Publisher : Frontiers Media SA
  • Release Date : 2015-11-13
  • Total pages : 284
  • ISBN : 2889196917
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Summary : Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident ...

A Role for Neuroinflammation and GST mediated Detoxification in Parkinson s Disease

A Role for Neuroinflammation and GST mediated Detoxification in Parkinson s Disease
  • Author : Angelika D. Wahner
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 236
  • ISBN : 2889196917
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Summary : Read online A Role for Neuroinflammation and GST mediated Detoxification in Parkinson s Disease written by Angelika D. Wahner, published by which was released on 2006. Download full A Role for Neuroinflammation and GST mediated Detoxification in Parkinson s Disease Books now! Available in PDF, ePub and Kindle....

Neuroinflammation

Neuroinflammation
  • Author : Paul L. Wood
  • Publisher : Springer Science & Business Media
  • Release Date : 2002-12-18
  • Total pages : 420
  • ISBN : 2889196917
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Summary : In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates ...

Neuroinflammation From Bench to Bedside

Neuroinflammation     From Bench to Bedside
  • Author : H. Kettenmann,G. Burton,U. Moenning
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-14
  • Total pages : 238
  • ISBN : 2889196917
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Summary : Recent work has implicated inflammatory processes in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and multiple sclerosis. In this book leading experts in the field discuss molecular, in vivo and clinical aspects of neuroinflammation. It is hoped, with the wealth of research being conductied ...

Neuroinflammation

Neuroinflammation
  • Author : Alireza Minagar
  • Publisher : Elsevier
  • Release Date : 2010-12-17
  • Total pages : 540
  • ISBN : 2889196917
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Summary : Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through ...

Neuroinflammation in Stroke

Neuroinflammation in Stroke
  • Author : Ulrich Dirnagl,Bernd Elger
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-17
  • Total pages : 224
  • ISBN : 2889196917
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Summary : The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ...

Role of Inflammation in Environmental Neurotoxicity

Role of Inflammation in Environmental Neurotoxicity
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-02-15
  • Total pages : 300
  • ISBN : 2889196917
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Summary : Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral ...

Neuroinflammation

Neuroinflammation
  • Author : Samuel David
  • Publisher : John Wiley & Sons
  • Release Date : 2015-03-11
  • Total pages : 304
  • ISBN : 2889196917
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Summary : Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have ...

Neuron Glia Interaction in Neuroinflammation

Neuron Glia Interaction in Neuroinflammation
  • Author : Akio Suzumura,Kazuhiro Ikenaka
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-09-13
  • Total pages : 187
  • ISBN : 2889196917
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Summary : Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the ...

Estrogens and Memory

Estrogens and Memory
  • Author : Karyn M. Frick
  • Publisher : Oxford University Press, USA
  • Release Date : 2020
  • Total pages : 516
  • ISBN : 2889196917
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Summary : "A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory ...

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration
  • Author : Phillip K. Peterson,Michal Toborek
  • Publisher : Springer
  • Release Date : 2014-07-08
  • Total pages : 600
  • ISBN : 2889196917
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Summary : State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s ...

Neuroinflammation and CNS Disorders

Neuroinflammation and CNS Disorders
  • Author : Nicola Woodroofe,Sandra Amor
  • Publisher : John Wiley & Sons
  • Release Date : 2014-04-15
  • Total pages : 424
  • ISBN : 2889196917
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Summary : The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to ...

Neuroinflammation

Neuroinflammation
  • Author : Mario Di Napoli,Francesca Papa
  • Publisher : Nova Science Pub Incorporated
  • Release Date : 2008-01-01
  • Total pages : 108
  • ISBN : 2889196917
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Summary : Ischemic stroke is a devastating clinical event. Increasing evidence suggests that inflammatory mechanisms are involved in the progression of post ischemic-induced brain injury. Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory mediators, including prostanoids, extracellular proteases, ...

Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives

Neuroinflammation and its Resolution  From Molecular Mechanisms to Therapeutic Perspectives
  • Author : Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-14
  • Total pages : 212
  • ISBN : 2889196917
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Summary : Read online Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives written by Morena Zusso,Stefano Moro,Pietro Giusti,Leanne Stokes, published by Frontiers Media SA which was released on 2020-07-14. Download full Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives Books now! Available in PDF, ...

Novel Roles of RelB in Neuroinflammation

Novel Roles of RelB in Neuroinflammation
  • Author : Angela Gupta
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 2889196917
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Summary : Neuroinflammation is hallmark of almost all central nervous system diseases. Along with infiltrating immune cells, resident glial cells of the central nervous system play a critical role in modulating inflammation and thus regulating disease severity. The NF-kB family of transcription factors are major transcriptional regulators of inflammation. RelA (p65) is ...