Multi Scale Approaches in Drug Discovery

Written By Alejandro Speck-Planche
Multi Scale Approaches in Drug Discovery
  • Publsiher : Elsevier
  • Release : 14 February 2017
  • ISBN : 008101242X
  • Pages : 238 pages
  • Rating : /5 from reviews
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Download or read book entitled Multi Scale Approaches in Drug Discovery by author: Alejandro Speck-Planche which was release on 14 February 2017 and published by Elsevier with total page 238 pages . This book available in PDF, EPUB and Kindle Format. Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents. After an introduction to multi-scale approaches outlining the need for and benefits of their use, the book goes on to explore a range of useful techniques and research areas, and their potential applications to this process. Profiling drug binding by thermodynamics, machine learning for predicting enzyme sub-classes, and multitasking models for computer-aided design and virtual compound screening are discussed, before the book goes on to review Alkaloid Menispermaceae leads, natural chemotherapeutic agents and methods for speeding up the design and virtual screening of therapeutic peptides. Flavonoids as multi-target compounds are then explored, before the book concludes with a review of Quasi-SMILES as a novel tool. Collecting together reviews and original research contributions written by leading experts in the field, Multi-Scale Approaches to Drug Discovery highlights cutting-edge approaches and practical examples of their implementation for those involved in the drug discovery process at many different levels. Using the combined knowledge of medicinal, computational, pharmaceutical and bio- chemists, it aims to support growth in the multi-scale approach to promote greater success in the development of new drugs. Offers practical guidance on ways to implement multiscale approaches for increased efficiency in drug discovery Draws on the experience of a highly skilled team of authors under the editorial guidance of one of the field's leading experts Includes cutting-edge techniques at the forefront of medicinal chemistry and drug discovery optimization

Multi Scale Approaches in Drug Discovery

Multi Scale Approaches in Drug Discovery
  • Author : Alejandro Speck-Planche
  • Publisher : Elsevier
  • Release Date : 2017-02-14
  • Total pages : 238
  • ISBN : 008101242X
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Summary : Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and ...

Programs and Services

Programs and Services
  • Author : National Library of Medicine (U.S.)
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online Programs and Services written by National Library of Medicine (U.S.), published by which was released on 2006. Download full Programs and Services Books now! Available in PDF, ePub and Kindle....

National Library of Medicine Programs and Services

National Library of Medicine Programs and Services
  • Author : National Library of Medicine (U.S.)
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online National Library of Medicine Programs and Services written by National Library of Medicine (U.S.), published by which was released on 2007. Download full National Library of Medicine Programs and Services Books now! Available in PDF, ePub and Kindle....

Multiscale Approaches to Protein Modeling

Multiscale Approaches to Protein Modeling
  • Author : Andrzej Kolinski
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-10-13
  • Total pages : 355
  • ISBN : 008101242X
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Summary : The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. ...

Multiscale Computational Methods in Chemistry and Physics

Multiscale Computational Methods in Chemistry and Physics
  • Author : Achi Brandt,Jerzy Bernholc,Kurt Binder,K. Binder
  • Publisher : Ios PressInc
  • Release Date : 2001
  • Total pages : 363
  • ISBN : 008101242X
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Summary : This book brings together interdisciplinary contributions ranging from applied mathematics, theoretical physics, quantum chemistry and molecular biology, all addressing various facets of the problem to connect the many different scales that one has to deal with in the computer simulation of many systems of interest in chemistry (e.g. polymeric ...

Phenotypic screening in the 21st century

Phenotypic screening in the 21st century
  • Author : Gul Erdemli,Birgit T Priest
  • Publisher : Frontiers Media SA
  • Release Date : 2015-04-21
  • Total pages : 212
  • ISBN : 008101242X
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Summary : In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of ...

Journal of the Royal Society Interface

Journal of the Royal Society  Interface
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online Journal of the Royal Society Interface written by , published by which was released on 2005. Download full Journal of the Royal Society Interface Books now! Available in PDF, ePub and Kindle....

Multiscale Operational Organic Chemistry

Multiscale Operational Organic Chemistry
  • Author : John W. Lehman
  • Publisher : Pearson College Division
  • Release Date : 2002
  • Total pages : 854
  • ISBN : 008101242X
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Summary : This practical laboratory book provides both microscale and multiscale experiments. It encourages readers to think in the laboratory by solving a scientific problem in the process of carrying out an experiment. An “operational” approach is featured, equipping readers to master the major lab operations as they carry out problem solving ...

Biomimetic Approaches in Engineering Practice

Biomimetic Approaches in Engineering Practice
  • Author : Stanislav Kolisnychenko
  • Publisher : Trans Tech Publications Ltd
  • Release Date : 2018-06-18
  • Total pages : 1852
  • ISBN : 008101242X
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Summary : Presented for your attention the special collection “Biomimetic Approaches in Engineering Practice” consists of papers published by Trans Tech Publications Inc. from 2010 up to 2016 and covers a wide range of engineering solutions in the fields of mechanical engineering, materials science, mechatronics, robotics, and architecture, where the principles of bionics were ...

Semantic Breakthrough in Drug Discovery

Semantic Breakthrough in Drug Discovery
  • Author : Bin Chen,Huijun Wang,Ying Ding,David Wild
  • Publisher : Morgan & Claypool Publishers
  • Release Date : 2014-10-01
  • Total pages : 142
  • ISBN : 008101242X
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Summary : The current drug development paradigm---sometimes expressed as, ``One disease, one target, one drug''---is under question, as relatively few drugs have reached the market in the last two decades. Meanwhile, the research focus of drug discovery is being placed on the study of drug action on biological systems as a whole, ...

Dissertation Abstracts International

Dissertation Abstracts International
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online Dissertation Abstracts International written by , published by which was released on 2007. Download full Dissertation Abstracts International Books now! Available in PDF, ePub and Kindle....

Chemical Engineering Progress

Chemical Engineering Progress
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online Chemical Engineering Progress written by , published by which was released on 2008. Download full Chemical Engineering Progress Books now! Available in PDF, ePub and Kindle....

Science Technology in Japan

Science   Technology in Japan
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online Science Technology in Japan written by , published by which was released on 2006. Download full Science Technology in Japan Books now! Available in PDF, ePub and Kindle....

Multiscale Simulation Approaches for Predicting Protein Ligand Binding Kinetics

Multiscale Simulation Approaches for Predicting Protein Ligand Binding Kinetics
  • Author : Benjamin Robert Jagger
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 129
  • ISBN : 008101242X
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Summary : A detailed understanding of the interaction between a drug candidate molecule and its target is essential for the development, optimization, and efficacy prediction of a drug. Kinetic parameters such as the association rate and residence time of a molecule have been shown to better correlate with in vivo efficacy than ...

AMSTAT News

AMSTAT News
  • Author : American Statistical Association
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 008101242X
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Summary : Read online AMSTAT News written by American Statistical Association, published by which was released on 2006. Download full AMSTAT News Books now! Available in PDF, ePub and Kindle....