Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Written By Pierfausto Seneci
Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Publsiher : Academic Press
  • Release : 07 October 2014
  • ISBN : 0128004991
  • Pages : 314 pages
  • Rating : /5 from reviews
GET THIS BOOKMolecular Targets in Protein Misfolding and Neurodegenerative Disease


Download or read book entitled Molecular Targets in Protein Misfolding and Neurodegenerative Disease by author: Pierfausto Seneci which was release on 07 October 2014 and published by Academic Press with total page 314 pages . This book available in PDF, EPUB and Kindle Format. Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2014-10-07
  • Total pages : 314
  • ISBN : 0128004991
GET BOOK

Summary : Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical ...

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-14
  • Total pages : 260
  • ISBN : 0128004991
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Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

Heat Shock Proteins and the Brain Implications for Neurodegenerative Diseases and Neuroprotection

Heat Shock Proteins and the Brain  Implications for Neurodegenerative Diseases and Neuroprotection
  • Author : Alexzander A.A. Asea,Ian R. Brown
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-04-06
  • Total pages : 373
  • ISBN : 0128004991
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Summary : With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein ...

Dissertation Abstracts International

Dissertation Abstracts International
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 0128004991
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Summary : Read online Dissertation Abstracts International written by , published by which was released on 2008. Download full Dissertation Abstracts International Books now! Available in PDF, ePub and Kindle....

Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases
  • Author : Richard I. Morimoto,Yves Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-13
  • Total pages : 136
  • ISBN : 0128004991
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Summary : The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of ...

Cell Injury

Cell Injury
  • Author : Raphael Carl Lee,Florin Despa,Kimm Jon Hamann,New York Academy of Sciences
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 329
  • ISBN : 0128004991
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Summary : When cells are damaged, as often occurs during trauma and metabolic stress, a highly evolved cell healing process follows that was designed to enhance cell survival or remove irreparably injured cells. Following injury, cells attempt to seal breaks in their membranes, chaperone removal or refolding of altered proteins, repair damaged ...

Interleukin 1 beta Folding and Aggregation

Interleukin 1 beta  Folding and Aggregation
  • Author : John Mason Finke
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 318
  • ISBN : 0128004991
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Summary : Read online Interleukin 1 beta Folding and Aggregation written by John Mason Finke, published by which was released on 2001. Download full Interleukin 1 beta Folding and Aggregation Books now! Available in PDF, ePub and Kindle....

Biochemistry and Cell Biology

Biochemistry and Cell Biology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2010
  • Total pages : 212
  • ISBN : 0128004991
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Summary : Read online Biochemistry and Cell Biology written by , published by which was released on 2010. Download full Biochemistry and Cell Biology Books now! Available in PDF, ePub and Kindle....

Investigations of the Roles of Hsp70 and Hsp40 Molecular Chaperone Proteins in Protein Folding

Investigations of the Roles of Hsp70 and Hsp40 Molecular Chaperone Proteins in Protein Folding
  • Author : Micheline Lisa Markey
  • Publisher : Unknown
  • Release Date : 1997
  • Total pages : 276
  • ISBN : 0128004991
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Summary : Read online Investigations of the Roles of Hsp70 and Hsp40 Molecular Chaperone Proteins in Protein Folding written by Micheline Lisa Markey, published by which was released on 1997. Download full Investigations of the Roles of Hsp70 and Hsp40 Molecular Chaperone Proteins in Protein Folding Books now! Available in PDF, ePub and ...

Wiley Encyclopedia of Molecular Medicine Volume 5

Wiley Encyclopedia of Molecular Medicine  Volume 5
  • Author : Wiley
  • Publisher : Wiley-Interscience
  • Release Date : 2001-11-01
  • Total pages : 3699
  • ISBN : 0128004991
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Summary : The field of molecular biology is revolutionizing human medicine and the applications of molecular biology to medicine are expanding. Encyclopedia of Molecular Medicine brings together those aspects of medicine that have significance at the molecular level, plus advances in molecular biology that are relevant to medicine. With over 1,700 separate primary ...

Protein Folding Disorders Of The Central Nervous System

Protein Folding Disorders Of The Central Nervous System
  • Author : Ghiso Jorge A,Rostagno Agueda A
  • Publisher : World Scientific
  • Release Date : 2017-09-15
  • Total pages : 336
  • ISBN : 0128004991
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Summary : This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." ...

The Journal of Cell Biology

The Journal of Cell Biology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 0128004991
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Summary : No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-...

The GABAA benzodiazepine Receptor as a Target for Psychoactive Drugs

The GABAA benzodiazepine Receptor as a Target for Psychoactive Drugs
  • Author : Adam Doble,Ian L. Martin
  • Publisher : Oxford University Press
  • Release Date : 1996
  • Total pages : 274
  • ISBN : 0128004991
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Summary : Electrophysiological studies w/the benzodiazepines/efficacy & receptor reserve/cyclopyrrolones/benzodiazepine abuse/etc....

The Role of ER Quality Control and Protein Misfolding in Retinal Degeneration Caused by a Mutation in Rhodopsin

The Role of ER Quality Control and Protein Misfolding in Retinal Degeneration Caused by a Mutation in Rhodopsin
  • Author : Rahul Sunder Rajan
  • Publisher : Unknown
  • Release Date : 2003
  • Total pages : 266
  • ISBN : 0128004991
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Summary : Read online The Role of ER Quality Control and Protein Misfolding in Retinal Degeneration Caused by a Mutation in Rhodopsin written by Rahul Sunder Rajan, published by which was released on 2003. Download full The Role of ER Quality Control and Protein Misfolding in Retinal Degeneration Caused by a Mutation in ...

Protein Misfolding

Protein Misfolding
  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release Date : 2020-01-13
  • Total pages : 450
  • ISBN : 0128004991
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Summary : Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein ...