Introduction to Biological and Small Molecule Drug Research and Development

Written By C. Robin Ganellin
Introduction to Biological and Small Molecule Drug Research and Development
  • Publsiher : Academic Press
  • Release : 07 May 2013
  • ISBN : 0123977703
  • Pages : 472 pages
  • Rating : /5 from reviews
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Download or read book entitled Introduction to Biological and Small Molecule Drug Research and Development by author: C. Robin Ganellin which was release on 07 May 2013 and published by Academic Press with total page 472 pages . This book available in PDF, EPUB and Kindle Format. Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
  • Publisher : Academic Press
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
GET BOOK

Summary : Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Jill M. Carton,William R. Strohl
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Throughout human history, the morbidity and mortality associated with human disease has driven medical science into an ever-expanding quest for treatment and cure. Over the past century, a therapeutic approach complementing chemical drugs has been developing which uses proteins and peptides in the treatment of disease. Many innovative protein therapeutic ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Wolfgang Jelkmann
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The renal hormone erythropoietin (Epo) is essential for the viability and proliferation of the erythrocytic progenitors generating reticulocytes in the bone marrow. Human Epo consists of a chain of 165 amino acid residues and four glycans. The synthesis of Epo is strongly stimulated by hypoxia. Epo deficiency is the primary cause ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : James Samanen
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Biotechnology has given rise to a broad range of biotherapies or biologics, including biomolecular drugs, vaccines, cell or gene therapies. This chapter focuses on biomolecular drugs, namely monoclonal antibodies (Mabs), cytokines, tissue growth factors and therapeutic proteins. Prior to the US approval of recombinant human insulin in 1982, biomolecular drugs were ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Matthew P. Coghlan,David Fairman
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The increasing global prevalence of type 2 diabetes represents a significant burden of disease for afflicted patients and for health care systems. In the developed world poorly controlled diabetes is the leading cause of non-traumatic amputation, blindness and end-stage renal disease requiring dialysis and kidney transplant. Additionally, diabetes represents a significant ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Andy Barker,David Anrews
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The epidermal growth factor receptor (EGFR) tyrosine kinase is a target for cancer chemotherapy. This chapter describes the discovery of small-molecule inhibitors of the kinase, their characterization and the medicinal chemistry programme that resulted in the identification of gefitinib. The development and studies undertaken to progress the drug in the ...

New Drug Development

New Drug Development
  • Author : J. Rick Turner
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-07-16
  • Total pages : 256
  • ISBN : 0123977703
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Summary : New Drug Development: Second Edition provides an overview of the design concepts and statistical practices involved in therapeutic drug development. This wide spectrum of activities begins with identifying a potentially useful drug candidate that can perhaps be used in the treatment or prevention of a condition of clinical concern, and ...

Handbook of Pharmaceutical Biotechnology

Handbook of Pharmaceutical Biotechnology
  • Author : Shayne C. Gad
  • Publisher : Wiley-Interscience
  • Release Date : 2007-06-11
  • Total pages : 1659
  • ISBN : 0123977703
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Summary : Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods....

The Science and Business of Drug Discovery

The Science and Business of Drug Discovery
  • Author : Edward D. Zanders
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-07-08
  • Total pages : 397
  • ISBN : 0123977703
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Summary : The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting ...

Bioinformatics and Computational Biology in Drug Discovery and Development

Bioinformatics and Computational Biology in Drug Discovery and Development
  • Author : William T. Loging
  • Publisher : Cambridge University Press
  • Release Date : 2016-02-29
  • Total pages : 248
  • ISBN : 0123977703
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Summary : A comprehensive overview of the use of computational biology approaches in the drug discovery and development process....

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 212
  • ISBN : 0123977703
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Summary : Read online Genetic Engineering Biotechnology News written by , published by which was released on 2009. Download full Genetic Engineering Biotechnology News Books now! Available in PDF, ePub and Kindle....

Drug Discovery and Development

Drug Discovery and Development
  • Author : H. P. Rang,Daniel Vasella
  • Publisher : Churchill Livingstone
  • Release Date : 2006
  • Total pages : 346
  • ISBN : 0123977703
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Summary : 'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful....

Biochemistry and Cell Biology

Biochemistry and Cell Biology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 0123977703
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Summary : Read online Biochemistry and Cell Biology written by , published by which was released on 2008. Download full Biochemistry and Cell Biology Books now! Available in PDF, ePub and Kindle....

The Small Molecule Microarray Synthesis Platform

The Small Molecule Microarray Synthesis Platform
  • Author : Matthew D. Bowman
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 308
  • ISBN : 0123977703
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Summary : Read online The Small Molecule Microarray Synthesis Platform written by Matthew D. Bowman, published by which was released on 2006. Download full The Small Molecule Microarray Synthesis Platform Books now! Available in PDF, ePub and Kindle....

Wiley Encyclopedia of Chemical Biology Volume 4

Wiley Encyclopedia of Chemical Biology  Volume 4
  • Author : Tadhg P. Begley
  • Publisher : Wiley-Blackwell
  • Release Date : 2009-02-03
  • Total pages : 828
  • ISBN : 0123977703
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Summary : The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the ...