Histone Modifications in Therapy

Written By Pedro Castelo-Branco
Histone Modifications in Therapy
  • Publsiher : Academic Press
  • Release : 21 August 2020
  • ISBN : 0128167408
  • Pages : 490 pages
  • Rating : /5 from reviews
GET THIS BOOKHistone Modifications in Therapy


Download or read book entitled Histone Modifications in Therapy by author: Pedro Castelo-Branco which was release on 21 August 2020 and published by Academic Press with total page 490 pages . This book available in PDF, EPUB and Kindle Format. Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists

Histone Modifications in Therapy

Histone Modifications in Therapy
  • Author : Pedro Castelo-Branco,Carmen Jeronimo
  • Publisher : Academic Press
  • Release Date : 2020-08-21
  • Total pages : 490
  • ISBN : 0128167408
GET BOOK

Summary : Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant ...

The Histone Code and Beyond

The Histone Code and Beyond
  • Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-01-19
  • Total pages : 215
  • ISBN : 0128167408
GET BOOK

Summary : Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The ...

The Histone Code and Beyond

The Histone Code and Beyond
  • Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
  • Publisher : Springer
  • Release Date : 2009-09-02
  • Total pages : 215
  • ISBN : 0128167408
GET BOOK

Summary : Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The ...

Epigenetics and Cancer

Epigenetics and Cancer
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2010-11-22
  • Total pages : 394
  • ISBN : 0128167408
GET BOOK

Summary : Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics ...

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy
  • Author : Steven Gray
  • Publisher : Academic Press
  • Release Date : 2015-07-01
  • Total pages : 748
  • ISBN : 0128167408
GET BOOK

Summary : Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the ...

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-05-18
  • Total pages : 518
  • ISBN : 0128167408
GET BOOK

Summary : Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ...

Personalized Epigenetics

Personalized Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2015-04-28
  • Total pages : 610
  • ISBN : 0128167408
GET BOOK

Summary : Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and ...

Epigenetic Modifications and Viral Infections

Epigenetic Modifications and Viral Infections
  • Author : Silvia Carolina Galvan,Alejandro García Carrancá,Félix Recillas-Targa,Jiuzhou Song
  • Publisher : Frontiers Media SA
  • Release Date : 2015-07-09
  • Total pages : 212
  • ISBN : 0128167408
GET BOOK

Summary : Epigenetics is defined as the study of modifications of the genome, heritable during cell division that does not involve changes in DNA sequences. Up to date, epigenetic modifications involve at least three general mechanisms regulating gene expression: histone modifications, DNA methylation, and non-coding RNAs (ncRNAs). For the past two decades, ...

Epigenetics in Human Disease

Epigenetics in Human Disease
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2018-05-18
  • Total pages : 1110
  • ISBN : 0128167408
GET BOOK

Summary : Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these ...

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release Date : 2015-11-19
  • Total pages : 498
  • ISBN : 0128167408
GET BOOK

Summary : Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found ...

Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell

Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell
  • Author : Yoshimasa Saito
  • Publisher : Frontiers E-books
  • Release Date : 2014-11-10
  • Total pages : 79
  • ISBN : 0128167408
GET BOOK

Summary : Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (...

Cancer Epigenetics

Cancer Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : CRC Press
  • Release Date : 2019-08-30
  • Total pages : 472
  • ISBN : 0128167408
GET BOOK

Summary : During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, ...

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer
  • Author : Michael Lübbert,Peter A. Jones
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-12-12
  • Total pages : 325
  • ISBN : 0128167408
GET BOOK

Summary : The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA ...

The Landscape of Histone Modification in Cancer Metastasis

The Landscape of Histone Modification in Cancer Metastasis
  • Author : Zhaoping Qiu
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0128167408
GET BOOK

Summary : Metastasis represents one of the most devastating aspects of cancer. Epithelial to mesenchymal transition (EMT) has been shown to play a critical role in tumorigenic metastasis. During metastatic progression, both genetic and epigenetic modifications endow cancer cells with properties that modulate the capacity for metastatic success. Histone modification is profoundly ...

Signal Transduction Pathways Chromatin Structure and Gene Expression Mechanisms as Therapeutic Targets

Signal Transduction Pathways  Chromatin Structure  and Gene Expression Mechanisms as Therapeutic Targets
  • Author : Marc Diederich
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 674
  • ISBN : 0128167408
GET BOOK

Summary : This volume describes recent findings in the field of fundamental signal transduction mechanisms, including protein kinesis as therapeutic targets as well as applied research toward angiogenesis, apoptosis, and chemopreventive agents....