High Throughput Bioanalytical Sample Preparation

Written By David A. Wells
High Throughput Bioanalytical Sample Preparation
  • Publsiher : Elsevier Science Limited
  • Release : 11 February 2003
  • ISBN :
  • Pages : 610 pages
  • Rating : /5 from reviews
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Download or read book entitled High Throughput Bioanalytical Sample Preparation by author: David A. Wells which was release on 11 February 2003 and published by Elsevier Science Limited with total page 610 pages . This book available in PDF, EPUB and Kindle Format. High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. · Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies · Thorough literature review and summary of published information · Detailed discussion and examples of the method development process

High Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation
  • Author : David A. Wells
  • Publisher : Elsevier Science Limited
  • Release Date : 2003-02-11
  • Total pages : 610
  • ISBN :
GET BOOK

Summary : High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. ...

Development and Validation of Automated Sample Preparation for High Throughput Bioanalysis

Development and Validation of Automated Sample Preparation for High Throughput Bioanalysis
  • Author : Robert Anthony Biddlecombe,University of Hertfordshire
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 212
  • ISBN :
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Summary : Read online Development and Validation of Automated Sample Preparation for High Throughput Bioanalysis written by Robert Anthony Biddlecombe,University of Hertfordshire, published by which was released on 2004. Download full Development and Validation of Automated Sample Preparation for High Throughput Bioanalysis Books now! Available in PDF, ePub and Kindle....

Sample Preparation in LC MS Bioanalysis

Sample Preparation in LC MS Bioanalysis
  • Author : Wenkui Li,Wenying Jian,Yunlin Fu
  • Publisher : John Wiley & Sons
  • Release Date : 2019-03-12
  • Total pages : 384
  • ISBN :
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Summary : Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass ...

Applied Biological Engineering

Applied Biological Engineering
  • Author : Ganesh R. Naik
  • Publisher : BoD – Books on Demand
  • Release Date : 2012-03-23
  • Total pages : 676
  • ISBN :
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Summary : Biological engineering is a field of engineering in which the emphasis is on life and life-sustaining systems. Biological engineering is an emerging discipline that encompasses engineering theory and practice connected to and derived from the science of biology. The most important trend in biological engineering is the dynamic range of ...

Sample Preparation in LC MS Bioanalysis

Sample Preparation in LC MS Bioanalysis
  • Author : Wenkui Li,Wenying Jian,Yunlin Fu
  • Publisher : John Wiley & Sons
  • Release Date : 2019-02-25
  • Total pages : 384
  • ISBN :
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Summary : Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass ...

Regulated Bioanalytical Laboratories

Regulated Bioanalytical Laboratories
  • Author : Michael Zhou
  • Publisher : John Wiley & Sons
  • Release Date : 2011-03-31
  • Total pages : 528
  • ISBN :
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Summary : This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on ...

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics E Book

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  • Author : Nader Rifai
  • Publisher : Elsevier Health Sciences
  • Release Date : 2017-01-16
  • Total pages : 1888
  • ISBN :
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Summary : The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the ...

Sample Preparation for Hyphenated Analytical Techniques

Sample Preparation for Hyphenated Analytical Techniques
  • Author : Jack Rosenfeld
  • Publisher : John Wiley & Sons
  • Release Date : 2009-02-12
  • Total pages : 240
  • ISBN :
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Summary : Linking “standard” but often mutually incompatible analytical techniques – so called hyphenation – generally leads to enhanced analytical performance, so hyphenated techniques are widely used in areas where samples are presented in complex matrices, eg environmental, pharmaceutical and biochemical analysis. With these hyphenated techniques, sample preparation is often the most time-consuming step ...

High Throughput Analysis in the Pharmaceutical Industry

High Throughput Analysis in the Pharmaceutical Industry
  • Author : Perry G. Wang
  • Publisher : CRC Press
  • Release Date : 2008-08-20
  • Total pages : 432
  • ISBN :
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Summary : The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the ...

Principles and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry
  • Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
  • Publisher : Elsevier
  • Release Date : 2018-06-26
  • Total pages : 216
  • ISBN :
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Summary : Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of ...

In tip Solid Phase Microextraction for High Throughput Drug Analysis

In tip Solid Phase Microextraction for High Throughput Drug Analysis
  • Author : Wei Xie
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 312
  • ISBN :
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Summary : This thesis describes the design of a convenient format of solid phase microextraction (SPME) for bioanalysis in pharmaceutical industry and the validation of the approach to the application. An automated in-tip SPME technique coupled with liquid chromatography (LC) and tandem mass spectrometry (MS/MS) for high throughout drug analysis has ...

Handbook of LC MS Bioanalysis

Handbook of LC MS Bioanalysis
  • Author : Wenkui Li,Jie Zhang,Francis L. S. Tse
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-03
  • Total pages : 704
  • ISBN :
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Summary : Consolidates the information LC-MS bioanalytical scientistsneed to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by newapproaches for developing bioanalytical methods, new liquidchromatographic (LC) techniques, and new mass spectrometric (MS)instruments. Moreover, there are a host of guidelines andregulations designed to ensure the quality of ...

Liquid Chromatography Mass Spectrometry

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  • Author : Wilfried M.A. Niessen
  • Publisher : CRC Press
  • Release Date : 2006-08-09
  • Total pages : 632
  • ISBN :
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Summary : A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and...

Modern Sample Preparation for Chromatography

Modern Sample Preparation for Chromatography
  • Author : Serban C. Moldoveanu,Victor David
  • Publisher : Elsevier
  • Release Date : 2014-10-18
  • Total pages : 453
  • ISBN :
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Summary : Sample preparation is applied to make real world samples amenable for chromatographic analysis, or to improve the results of this type of analysis. A wide variety of procedures are applied for this purpose, and their description is the main goal of the present book. The principles of these procedures are ...

Enzyme Inhibition in Drug Discovery and Development

Enzyme Inhibition in Drug Discovery and Development
  • Author : Chuang Lu,Albert P. Li
  • Publisher : John Wiley & Sons
  • Release Date : 2010-01-26
  • Total pages : 868
  • ISBN :
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Summary : The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug ...