Genomic Biomarkers for Pharmaceutical Development

Written By Yihong Yao
Genomic Biomarkers for Pharmaceutical Development
  • Publsiher : Academic Press
  • Release : 16 July 2013
  • ISBN : 0123977940
  • Pages : 208 pages
  • Rating : /5 from reviews
GET THIS BOOKGenomic Biomarkers for Pharmaceutical Development


Download or read book entitled Genomic Biomarkers for Pharmaceutical Development by author: Yihong Yao which was release on 16 July 2013 and published by Academic Press with total page 208 pages . This book available in PDF, EPUB and Kindle Format. Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs Authored by leading international experts from industry and academia

Genomic Biomarkers for Pharmaceutical Development

Genomic Biomarkers for Pharmaceutical Development
  • Author : Yihong Yao,Bahija Jallal,Koustubh Ranade
  • Publisher : Academic Press
  • Release Date : 2013-07-16
  • Total pages : 208
  • ISBN : 0123977940
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Summary : Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing ...

Genomic Biomarkers for Pharmaceutical Development

Genomic Biomarkers for Pharmaceutical Development
  • Author : Cornelis L. Verweij,Brandon W. Higgs,Yihong Yao
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-16
  • Total pages : 208
  • ISBN : 0123977940
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Summary : Autoimmune diseases constitute a wide range of mostly complex and multifactorial disorders that are difficult to treat. Increasing insight in the pathogenesis of autoimmune diseases has led to development of targeted therapies aimed at regulating key components of the disease pathways. In particular, the advent of biologic therapeutics has led ...

Genomic Biomarkers for Pharmaceutical Development

Genomic Biomarkers for Pharmaceutical Development
  • Author : Nicholas C. Dracopoli,Katie Streicher
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-16
  • Total pages : 208
  • ISBN : 0123977940
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Summary : The goal of personalized healthcare in the treatment of cancer is to reduce the attrition of novel oncology drugs and improve patient outcomes. The discovery and application of novel biomarkers is essential for the successful implementation of personalized healthcare for cancer patients. This chapter focuses on the types of biomarkers ...

Genomic Biomarkers for Pharmaceutical Development

Genomic Biomarkers for Pharmaceutical Development
  • Author : Yuping Wang,Jurgen Borlak,Weida Tong
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-16
  • Total pages : 208
  • ISBN : 0123977940
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Summary : Although we have seen increased spending on drug research and development, the submission of new drug applications to the US Food and Drug Administration (FDA) has steadily decreased over the past 15 years. Meanwhile, toxicology is celebrating the ten-year anniversary of the introduction of toxicogenomics, a field that was anticipated to ...

Genomic Biomarkers for Pharmaceutical Development

Genomic Biomarkers for Pharmaceutical Development
  • Author : Elizabeth Mambo,Anna E. Szafranska-Schwarzbach,Gary Latham,Alex Adai,Annette Schlageter,Bernard Andruss
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-16
  • Total pages : 208
  • ISBN : 0123977940
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Summary : The focus of this chapter is on the development of miRNA diagnostics and the process for miRNA biomarker development. We discuss pancreatic cancer as a model for the application of miRNA-based tests in different clinical biopsy specimen types. Asuragen’s miRInform® Pancreas test illustrates the development of a laboratory developed ...

Genomic Biomarkers for Pharmaceutical Development

Genomic Biomarkers for Pharmaceutical Development
  • Author : Philip Brohawn,Brandon W. Higgs,Koustubh Ranade,Bahija Jallal,Yihong Yao
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-16
  • Total pages : 208
  • ISBN : 0123977940
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Summary : This chapter presents the processes required for the translation of a biomarker discovery from the research laboratory into a validated diagnostic for clinical application. To fully investigate the topic of assay validation, a brief review of the current regulatory guidance will be discussed, and thereafter this is used as the ...

Genomics in Drug Discovery and Development

Genomics in Drug Discovery and Development
  • Author : Dimitri Semizarov,Eric Blomme
  • Publisher : John Wiley & Sons
  • Release Date : 2008-11-03
  • Total pages : 480
  • ISBN : 0123977940
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Summary : Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, ...

Biomarkers in Drug Discovery and Development

Biomarkers in Drug Discovery and Development
  • Author : Ramin Rahbari,Jonathan Van Niewaal,Michael R. Bleavins
  • Publisher : John Wiley & Sons
  • Release Date : 2020-02-28
  • Total pages : 608
  • ISBN : 0123977940
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Summary : This book continues the legacy of a well-established reference within the pharmaceutical industry – providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker characterization and validation and applications throughout drug discovery and development. • Explains where proper use of biomarkers can substantively impact ...

Biomarkers in Drug Development

Biomarkers in Drug Development
  • Author : Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-20
  • Total pages : 784
  • ISBN : 0123977940
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Summary : Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational ...

Handbook of Pharmaceutical Biotechnology

Handbook of Pharmaceutical Biotechnology
  • Author : Shayne C. Gad
  • Publisher : Wiley-Interscience
  • Release Date : 2007-06-11
  • Total pages : 1659
  • ISBN : 0123977940
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Summary : Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods....

Reasonable Rx

Reasonable Rx
  • Author : Stan Finkelstein,Stan N. Finkelstein,Peter Temin
  • Publisher : FT Press
  • Release Date : 2008
  • Total pages : 188
  • ISBN : 0123977940
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Summary : Explores the problem of high drug prices by taking a close look at the science of drug development, how the drug industry operates, how new drugs are discovered, and how the government affects and controls these processes. By examining recent changes in the pharmaceutical industry in more depth, the authors ...

The Path from Biomarker Discovery to Regulatory Qualification

The Path from Biomarker Discovery to Regulatory Qualification
  • Author : Federico Goodsaid,William B. Mattes
  • Publisher : Academic Press
  • Release Date : 2013-07-16
  • Total pages : 206
  • ISBN : 0123977940
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Summary : The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, ...

Predictive Approaches in Drug Discovery and Development

Predictive Approaches in Drug Discovery and Development
  • Author : J. Andrew Williams,Richard Lalonde,Jeffrey R. Koup,David D. Christ
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-10
  • Total pages : 408
  • ISBN : 0123977940
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Summary : Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with ...

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 212
  • ISBN : 0123977940
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Summary : Read online Genetic Engineering Biotechnology News written by , published by which was released on 2009. Download full Genetic Engineering Biotechnology News Books now! Available in PDF, ePub and Kindle....

Genetic Engineering News

Genetic Engineering News
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 0123977940
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Summary : Read online Genetic Engineering News written by , published by which was released on 2006. Download full Genetic Engineering News Books now! Available in PDF, ePub and Kindle....