Genome Stability

Written By Igor Kovalchuk
Genome Stability
  • Publsiher : Academic Press
  • Release : 03 September 2016
  • ISBN : 0128033452
  • Pages : 712 pages
  • Rating : /5 from reviews
GET THIS BOOKGenome Stability


Download or read book entitled Genome Stability by author: Igor Kovalchuk which was release on 03 September 2016 and published by Academic Press with total page 712 pages . This book available in PDF, EPUB and Kindle Format. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability and its effect on human diseases Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release Date : 2016-09-03
  • Total pages : 712
  • ISBN : 0128033452
GET BOOK

Summary : Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made ...

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Pub
  • Release Date : 2014
  • Total pages : 399
  • ISBN : 0128033452
GET BOOK

Summary : "Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An ...

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Release Date : 2016-09-30
  • Total pages : 710
  • ISBN : 0128033452
GET BOOK

Summary : "Genome Stability: From Virus to Human Application" covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in ...

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release Date : 2013-12-16
  • Total pages : 416
  • ISBN : 0128033452
GET BOOK

Summary : Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An...

Genome Stability and Human Diseases

Genome Stability and Human Diseases
  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-11
  • Total pages : 340
  • ISBN : 0128033452
GET BOOK

Summary : Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the ...

Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle

Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle
  • Author : Jennifer Teresa Thomas
  • Publisher : Unknown
  • Release Date : 1999
  • Total pages : 141
  • ISBN : 0128033452
GET BOOK

Summary : Understanding how human papillomaviruses (HPVs) induce the proliferative lesions associated with genital warts and cervical cancers relies on our appreciation of the functions of the E6 and E7 viral proteins. These "oncoproteins" of the high risk HPV types interfere with the activities of cellular tumor suppressor proteins; E7 proteins act ...

Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer

Mobile Genetic Elements in Cellular Differentiation  Genome Stability  and Cancer
  • Author : Tammy A. Morrish,Jose Luis García Pérez
  • Publisher : Frontiers Media SA
  • Release Date : 2018-01-16
  • Total pages : 212
  • ISBN : 0128033452
GET BOOK

Summary : The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of ...

MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress

MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress
  • Author : Anca Macovei,Ignacio Rubio Somoza,Jorge Almiro P. Paiva,Susana Araújo,Mattia Donà
  • Publisher : Frontiers Media SA
  • Release Date : 2021-05-25
  • Total pages : 212
  • ISBN : 0128033452
GET BOOK

Summary : Read online MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress written by Anca Macovei,Ignacio Rubio Somoza,Jorge Almiro P. Paiva,Susana Araújo,Mattia Donà, published by Frontiers Media SA which was released on 2021-05-25. Download full MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress Books ...

Maintaining Genome Stability The Role of Helicases and Deaminases

Maintaining Genome Stability  The Role of Helicases and Deaminases
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 90
  • ISBN : 0128033452
GET BOOK

Summary : Both helicases and deaminases are enzymes that play an important role in maintaining genomic stability and immune responses. Errors in duplicating DNA can result in genomic instability, leading to various human diseases, such as cancer, immune system disorder, muscle dystrophy, and neurodegenerations. Thus, maintaining genomic integrity is vital to the ...

The Genome Stability is Preserved by a Stress Response Protein CCDC6

The Genome Stability is Preserved by a Stress Response Protein  CCDC6
  • Author : Chiara Luise,Angela Celetti
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2012-07
  • Total pages : 80
  • ISBN : 0128033452
GET BOOK

Summary : The maintenance of genomic stability is beneficial for the survival of an individual cell and crucial for cancer avoidance. Cells invest huge resources to maintain genomic stability, and cancer cells undergo an array of genetic changes to escape these barriers. The initiation of carcinogenesis represents a mutational event, which in ...

Promoting Genome Stability Via Multiple Dna Repair Pathways

Promoting Genome Stability Via Multiple Dna Repair Pathways
  • Author : Scott Cukras
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 212
  • ISBN : 0128033452
GET BOOK

Summary : ABSTRACT Maintaining genome integrity is indispensible for cells to prevent and limit accruement of deleterious mutations and to promote viable cell growth and proliferation. Cells possess a myriad of mechanisms to detect, prevent and repair incurred cellular damage. Here we discuss various proteins and their accompanying cellular pathways that promote ...

Trypanosoma Brucei BRCA2 in the Regulation of Genome Stability and DNA Repair

Trypanosoma Brucei BRCA2 in the Regulation of Genome Stability and DNA Repair
  • Author : Anna Louise Trenaman
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 316
  • ISBN : 0128033452
GET BOOK

Summary : Read online Trypanosoma Brucei BRCA2 in the Regulation of Genome Stability and DNA Repair written by Anna Louise Trenaman, published by which was released on 2012. Download full Trypanosoma Brucei BRCA2 in the Regulation of Genome Stability and DNA Repair Books now! Available in PDF, ePub and Kindle....

Functional Roles of Nucleases in DNA Metabolism and Genome Stability

Functional Roles of Nucleases in DNA Metabolism and Genome Stability
  • Author : Justin Lee Sparks
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 162
  • ISBN : 0128033452
GET BOOK

Summary : The work outlined in this dissertation focuses on two distinct areas that are important for genome stability. Both areas focus on DNA repair pathways that require the action of nucleases, specifically Exonuclease 5 and Ribonuclease H2. First, I describe the biochemical and molecular characterization of the novel Exonuclease 5 family of enzymes ...

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination
  • Author : Juan Argueso Almeida
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 296
  • ISBN : 0128033452
GET BOOK

Summary : Mismatch repair (MMR) systems correct mismatches formed during DNA replication and genetic recombination and as the result of DNA damage. MMR is initiated by a conserved family of MutS (MSH) and MutL (MLH) homolog proteins. MLH1 is unique among these proteins because it is also required for high levels of ...

Genome Instability and Transgenerational Effects

Genome Instability and Transgenerational Effects
  • Author : Igor Kovalchuk,Olga Kovalchuk (MD.)
  • Publisher : Nova Science Pub Incorporated
  • Release Date : 2010
  • Total pages : 472
  • ISBN : 0128033452
GET BOOK

Summary : Genome stability of every species depends on complex interaction of predefined and environmentally induced genetic and epigenetic states. Predefined states consist of chromatin structure and cell metabolic processes such as DNA repair, radical scavenging and cell signalling, whereas induced states depend on interactions with the environment. Organisms are able to ...