Drug like Properties

Written By Li Di
Drug like Properties
  • Publsiher : Academic Press
  • Release : 12 January 2016
  • ISBN : 9780128010761
  • Pages : 580 pages
  • Rating : /5 from reviews
GET THIS BOOKDrug like Properties


Download or read book entitled Drug like Properties by author: Li Di which was release on 12 January 2016 and published by Academic Press with total page 580 pages . This book available in PDF, EPUB and Kindle Format. Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors' recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

Drug Like Properties

Drug Like Properties
  • Author : Li Di,Edward H Kerns
  • Publisher : Academic Press
  • Release Date : 2015-12-17
  • Total pages : 580
  • ISBN : 9780128010761
GET BOOK

Summary : Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like ...

Drug like Properties

Drug like Properties
  • Author : Li Di,Edward H. Kerns
  • Publisher : Academic Press
  • Release Date : 2016-01-12
  • Total pages : 580
  • ISBN : 9780128010761
GET BOOK

Summary : Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like ...

Optimizing the Drug Like Properties of Leads in Drug Discovery

Optimizing the  Drug Like  Properties of Leads in Drug Discovery
  • Author : Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens
  • Publisher : Springer
  • Release Date : 2006-09-25
  • Total pages : 512
  • ISBN : 9780128010761
GET BOOK

Summary : This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines ...

Optimizing the Drug Like Properties of Leads in Drug Discovery

Optimizing the  Drug Like  Properties of Leads in Drug Discovery
  • Author : Ronald Borchardt,Edward Kerns,Michael Hageman,Dhrien Thakker,James Stevens
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-31
  • Total pages : 512
  • ISBN : 9780128010761
GET BOOK

Summary : This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines ...

Discovering and Developing Molecules with Optimal Drug Like Properties

Discovering and Developing Molecules with Optimal Drug Like Properties
  • Author : Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E. Prisinzano
  • Publisher : Springer
  • Release Date : 2014-10-31
  • Total pages : 511
  • ISBN : 9780128010761
GET BOOK

Summary : This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an ...

ADMET for Medicinal Chemists

ADMET for Medicinal Chemists
  • Author : Katya Tsaioun,Steven A. Kates
  • Publisher : John Wiley & Sons
  • Release Date : 2011-02-15
  • Total pages : 512
  • ISBN : 9780128010761
GET BOOK

Summary : This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of ...

Optimization in Drug Discovery

Optimization in Drug Discovery
  • Author : Zhengyin Yan,Gary Caldwell
  • Publisher : Springer Science & Business Media
  • Release Date : 2004
  • Total pages : 418
  • ISBN : 9780128010761
GET BOOK

Summary : Recent reports of drug attrition rates have revealed that a significant number of drug candidates fail in the later stage of clinical development due to absorption, distribution, metabolism, elimination and toxicity issues. Lead optimization in drug discovery, a process of attempting to uncover and correct these defects, is highly beneficial ...

Absorption and Drug Development

Absorption and Drug Development
  • Author : Alex Avdeef
  • Publisher : John Wiley & Sons
  • Release Date : 2003-09-19
  • Total pages : 312
  • ISBN : 9780128010761
GET BOOK

Summary : Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, ...

Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
  • Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-07
  • Total pages : 214
  • ISBN : 9780128010761
GET BOOK

Summary : Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. ...

Drug like Properties Concepts Structure Design and Methods

Drug like Properties  Concepts  Structure Design and Methods
  • Author : Li Di,Edward H Kerns
  • Publisher : Elsevier
  • Release Date : 2010-07-26
  • Total pages : 552
  • ISBN : 9780128010761
GET BOOK

Summary : Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance ...

Optimization in Drug Discovery

Optimization in Drug Discovery
  • Author : Zhengyin Yan,Gary W. Caldwell
  • Publisher : Humana Press
  • Release Date : 2004-08-11
  • Total pages : 420
  • ISBN : 9780128010761
GET BOOK

Summary : Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is ...

Structure based Design of Drugs and Other Bioactive Molecules

Structure based Design of Drugs and Other Bioactive Molecules
  • Author : Arun K. Ghosh,Sandra Gemma
  • Publisher : John Wiley & Sons
  • Release Date : 2014-07-16
  • Total pages : 474
  • ISBN : 9780128010761
GET BOOK

Summary : Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary ...

Investigation of the Relationship Between Peptide Structure and Their Drug like Properties

Investigation of the Relationship Between Peptide Structure and Their Drug like Properties
  • Author : Oded Ovadia
  • Publisher : Unknown
  • Release Date : 2010
  • Total pages : 216
  • ISBN : 9780128010761
GET BOOK

Summary : Read online Investigation of the Relationship Between Peptide Structure and Their Drug like Properties written by Oded Ovadia, published by which was released on 2010. Download full Investigation of the Relationship Between Peptide Structure and Their Drug like Properties Books now! Available in PDF, ePub and Kindle....

Pharmacokinetic Profiling in Drug Research

Pharmacokinetic Profiling in Drug Research
  • Author : Bernard Testa,Stefanie D. Krämer,Heidi Wunderli-Allenspach,Gerd Folkers
  • Publisher : Wiley-VCH
  • Release Date : 2006-03-10
  • Total pages : 500
  • ISBN : 9780128010761
GET BOOK

Summary : Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of 'hits', which invade the databases like swarms of locusts. But far ...

Textbook of Drug Design and Discovery Fifth Edition

Textbook of Drug Design and Discovery  Fifth Edition
  • Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release Date : 2016-08-19
  • Total pages : 450
  • ISBN : 9780128010761
GET BOOK

Summary : Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is ...