Drug Discovery in Cancer Epigenetics

Written By Gerda Egger
Drug Discovery in Cancer Epigenetics
  • Publsiher : Academic Press
  • Release : 19 November 2015
  • ISBN : 0128024925
  • Pages : 498 pages
  • Rating : /5 from reviews
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Download or read book entitled Drug Discovery in Cancer Epigenetics by author: Gerda Egger which was release on 19 November 2015 and published by Academic Press with total page 498 pages . This book available in PDF, EPUB and Kindle Format. Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release Date : 2015-11-19
  • Total pages : 498
  • ISBN : 0128024925
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Summary : Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found ...

Epigenetics for Drug Discovery

Epigenetics for Drug Discovery
  • Author : Nessa Carey
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • Total pages : 321
  • ISBN : 0128024925
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Summary : This book will provide an invaluable guide to epigenetics, one of the fastest moving fields in drug discovery, for medicinal chemists working in academia and in the pharmaceutical industry....

Epigenetic Approaches in Drug Discovery Development and Treatment

Epigenetic Approaches in Drug Discovery  Development and Treatment
  • Author : Shibashish Giri,Chandravanu Dash
  • Publisher : Frontiers Media SA
  • Release Date : 2020-08-07
  • Total pages : 212
  • ISBN : 0128024925
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Summary : Establishment of a normal phenotype involves dynamic epigenetic regulation of gene expression that when affected contributes to human diseases. On a molecular level, epigenetic regulation is marked by specific covalent modifications (acetylation, methylation, phosphorylation, sumoylation, PARylation and ubiquitylation) of DNA and its associated histones. Studies also suggest the influence of ...

Cancer Epigenetics

Cancer Epigenetics
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : John Wiley & Sons
  • Release Date : 2011-10-07
  • Total pages : 448
  • ISBN : 0128024925
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Summary : Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences....

Epigenetic Drug Discovery

Epigenetic Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : John Wiley & Sons
  • Release Date : 2019-03-25
  • Total pages : 504
  • ISBN : 0128024925
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Summary : This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any ...

Epigenetic Pharmacology and Therapeutics

Epigenetic Pharmacology and Therapeutics
  • Author : Zacharoula Konsoula
  • Publisher : Elsevier
  • Release Date : 2014-11-12
  • Total pages : 128
  • ISBN : 0128024925
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Summary : Epigenetic Pharmacology and Therapeutics highlights the interface between epigenetics and pharmacology by examining the role of epigenetics in the regulation of ADME genes and metabolism and delineating the importance of epigenetic enzymes in nuclear receptors signaling. This book discusses in detail the current trends in epigenetic therapy in cancer, epigenetic ...

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer
  • Author : Michael Lübbert,Peter A. Jones
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-12-12
  • Total pages : 325
  • ISBN : 0128024925
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Summary : The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA ...

Epigenetics and Disease

Epigenetics and Disease
  • Author : Susan M. Gasser,En Li
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-10-17
  • Total pages : 270
  • ISBN : 0128024925
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Summary : Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system ...

DNA and Histone Methylation as Cancer Targets

DNA and Histone Methylation as Cancer Targets
  • Author : Atsushi Kaneda,Yu-ichi Tsukada
  • Publisher : Humana Press
  • Release Date : 2017-09-12
  • Total pages : 624
  • ISBN : 0128024925
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Summary : This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, ...

Gynecological Cancers

Gynecological Cancers
  • Author : Antonio Giordano,Marcella Macaluso
  • Publisher : Springer
  • Release Date : 2016-07-12
  • Total pages : 173
  • ISBN : 0128024925
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Summary : Facilitating the collaboration between the basic, translational, and clinical sciences, this book provides an overview of the genetic and epigenetic mechanisms underlying the formation and progression of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development gathers all of the molecular and cellular aspects of gynecological cancer together ...

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-05-18
  • Total pages : 518
  • ISBN : 0128024925
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Summary : Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ...

Pharmacoepigenetics

Pharmacoepigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-06-04
  • Total pages : 983
  • ISBN : 0128024925
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Summary : Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the ...

Successful Drug Discovery

Successful Drug Discovery
  • Author : János Fischer,Wayne E. Childers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-11-04
  • Total pages : 292
  • ISBN : 0128024925
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Summary : Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 ...

Epigenetic Targets in Drug Discovery

Epigenetic Targets in Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : Wiley-VCH
  • Release Date : 2009-08-03
  • Total pages : 314
  • ISBN : 0128024925
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Summary : Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via ...

Cancer Research

Cancer Research
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2009-02
  • Total pages : 212
  • ISBN : 0128024925
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Summary : Read online Cancer Research written by , published by which was released on 2009-02. Download full Cancer Research Books now! Available in PDF, ePub and Kindle....