DNA Repair in Cancer Therapy
  • Release Date : 19 March 2004
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 363 pages
  • ISBN 13 : 9781592597352
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Download or read book entitled DNA Repair in Cancer Therapy by author: Lawrence C. Panasci which was release on 19 March 2004 and published by Springer Science & Business Media with total page 363 pages . This book available in PDF, EPUB and Kindle Format. A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.