Developing Therapeutics for Alzheimer s Disease

Written By Michael S. Wolfe
Developing Therapeutics for Alzheimer s Disease
  • Publsiher : Academic Press
  • Release : 27 May 2016
  • ISBN : 0128021640
  • Pages : 676 pages
  • Rating : /5 from reviews
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Download or read book entitled Developing Therapeutics for Alzheimer s Disease by author: Michael S. Wolfe which was release on 27 May 2016 and published by Academic Press with total page 676 pages . This book available in PDF, EPUB and Kindle Format. Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Developing Therapeutics for Alzheimer s Disease

Developing Therapeutics for Alzheimer s Disease
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2016-05-27
  • Total pages : 676
  • ISBN : 0128021640
GET BOOK

Summary : Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that ...

Neurofibrillary Tangles as a Target for Developing New Therapeutics for Alzheimer s Disease

Neurofibrillary Tangles as a Target for Developing New Therapeutics for Alzheimer s Disease
  • Author : Howard M. Fillit,Lorenzo M. Refolo
  • Publisher : Unknown
  • Release Date : 2002
  • Total pages : 97
  • ISBN : 0128021640
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Summary : Read online Neurofibrillary Tangles as a Target for Developing New Therapeutics for Alzheimer s Disease written by Howard M. Fillit,Lorenzo M. Refolo, published by which was released on 2002. Download full Neurofibrillary Tangles as a Target for Developing New Therapeutics for Alzheimer s Disease Books now! Available in PDF, ePub ...

Pharmacological Mechanisms in Alzheimer s Therapeutics

Pharmacological Mechanisms in Alzheimer s Therapeutics
  • Author : A. Claudio Cuello
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-22
  • Total pages : 324
  • ISBN : 0128021640
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Summary : The need for effective therapy to treat Alzheimer’s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of ...

BACE

BACE
  • Author : Varghese John
  • Publisher : John Wiley & Sons
  • Release Date : 2010-03-05
  • Total pages : 272
  • ISBN : 0128021640
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Summary : BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers ...

Amyloid Protein Precursor in Development Aging and Alzheimer s Disease

Amyloid Protein Precursor in Development  Aging and Alzheimer   s Disease
  • Author : C.L. Masters,K. Beyreuther,Marc Trillet
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-17
  • Total pages : 257
  • ISBN : 0128021640
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Summary : This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding ...

BACE

BACE
  • Author : Varghese John
  • Publisher : John Wiley & Sons
  • Release Date : 2010-03-15
  • Total pages : 288
  • ISBN : 0128021640
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Summary : BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers ...

Therapeutic Opportunities in Alzheimer s Disease

Therapeutic Opportunities in Alzheimer s Disease
  • Author : Katherine Emory
  • Publisher : Unknown
  • Release Date : 1996-11-01
  • Total pages : 212
  • ISBN : 0128021640
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Summary : Read online Therapeutic Opportunities in Alzheimer s Disease written by Katherine Emory, published by which was released on 1996-11-01. Download full Therapeutic Opportunities in Alzheimer s Disease Books now! Available in PDF, ePub and Kindle....

Neuroprotection in Alzheimer s Disease

Neuroprotection in Alzheimer s Disease
  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release Date : 2016-12-30
  • Total pages : 342
  • ISBN : 0128021640
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Summary : Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together ...

Treatment Development Strategies for Alzheimer s Disease

Treatment Development Strategies for Alzheimer s Disease
  • Author : Thomas Crook,Raymond T. Bartus,Steven Ferris
  • Publisher : Unknown
  • Release Date : 1986
  • Total pages : 699
  • ISBN : 0128021640
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Summary : Read online Treatment Development Strategies for Alzheimer s Disease written by Thomas Crook,Raymond T. Bartus,Steven Ferris, published by which was released on 1986. Download full Treatment Development Strategies for Alzheimer s Disease Books now! Available in PDF, ePub and Kindle....

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • Total pages : 118
  • ISBN : 0128021640
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Summary : Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling ...

Preclinical and clinical issues in Alzheimer s disease drug research and development

Preclinical and clinical issues in Alzheimer   s disease drug research and development
  • Author : Cesare Mancuso,Silvana Gaetani
  • Publisher : Frontiers Media SA
  • Release Date : 2015-03-03
  • Total pages : 212
  • ISBN : 0128021640
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Summary : Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor ...

Breakthrough Business Models

Breakthrough Business Models
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Robert Giffin,Sally Robinson,Theresa Wizemann
  • Publisher : National Academies Press
  • Release Date : 2009-03-17
  • Total pages : 150
  • ISBN : 0128021640
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Summary : The process for developing new drug and biologic products is extraordinarily expensive and time-consuming. Although large pharmaceutical companies may be able to afford the cost of development because they can expect a large return on investment, organizations developing drugs to treat rare and neglected diseases are unable to rely on ...

Role of Misfolded Proteins in the Pathogenesis of Neurodegenerative Disorders and Challenges impacting the development of Novel Therapies An Overview

Role of Misfolded Proteins in the Pathogenesis of Neurodegenerative Disorders and Challenges impacting the development of Novel Therapies  An Overview
  • Author : Dr.Hakim Saboowala
  • Publisher : Dr.Hakim Saboowala
  • Release Date : 2020-11-09
  • Total pages : 70
  • ISBN : 0128021640
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Summary : Role of Misfolded Proteins in the Pathogenesis of Neurodegenerative Disorders and Challenges impacting the development of Novel Therapies. An Overview. A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic targeting of protein misfolding has generated unique ...

Global Clinical Trials for Alzheimer s Disease

Global Clinical Trials for Alzheimer s Disease
  • Author : Menghis Bairu,Michael Weiner
  • Publisher : Academic Press
  • Release Date : 2013-08-28
  • Total pages : 432
  • ISBN : 0128021640
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Summary : Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical ...

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release Date : 2016-09-20
  • Total pages : 316
  • ISBN : 0128021640
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Summary : Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and ...