Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Written By Pierfausto Seneci
Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Publsiher : Academic Press
  • Release : 12 January 2015
  • ISBN : 9780128019443
  • Pages : 260 pages
  • Rating : /5 from reviews
GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease


Download or read book entitled Chemical Modulators of Protein Misfolding and Neurodegenerative Disease by author: Pierfausto Seneci which was release on 12 January 2015 and published by Academic Press with total page 260 pages . This book available in PDF, EPUB and Kindle Format. This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. • Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds; • Provides discipline-specific chapters that cover medicinal chemistry and clinical applications; • Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder; • Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-12
  • Total pages : 260
  • ISBN : 9780128019443
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Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2014-10-07
  • Total pages : 314
  • ISBN : 9780128019443
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Summary : Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical ...

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-14
  • Total pages : 260
  • ISBN : 9780128019443
GET BOOK

Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release Date : 2019-11-18
  • Total pages : 384
  • ISBN : 9780128019443
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Summary : Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on ...

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders
  • Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
  • Publisher : IGI Global
  • Release Date : 2020-02-14
  • Total pages : 515
  • ISBN : 9780128019443
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Summary : Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of ...

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release Date : 2018-06-05
  • Total pages : 194
  • ISBN : 9780128019443
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Summary : Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways ...

Proteostasis and Chaperone Surveillance

Proteostasis and Chaperone Surveillance
  • Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
  • Publisher : Springer
  • Release Date : 2015-11-26
  • Total pages : 180
  • ISBN : 9780128019443
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Summary : Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, ...

Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Methods for Optical Imaging and Conjugation

Chemical Tools for Imaging  Manipulating  and Tracking Biological Systems  Diverse Methods for Optical Imaging and Conjugation
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-05-29
  • Total pages : 430
  • ISBN : 9780128019443
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Summary : Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation, Volume 639, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Fluorogenic detection ...

Protein Misfolding

Protein Misfolding
  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release Date : 2020-01-13
  • Total pages : 450
  • ISBN : 9780128019443
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Summary : Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein ...

Folding for the Synapse

Folding for the Synapse
  • Author : Andreas Wyttenbach,Vincent O'Connor
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-10-22
  • Total pages : 318
  • ISBN : 9780128019443
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Summary : Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of ...

Advances in Molecular Toxicology

Advances in Molecular Toxicology
  • Author : James C. Fishbein,Jacqueline M. Heilman
  • Publisher : Academic Press
  • Release Date : 2019-10-12
  • Total pages : 164
  • ISBN : 9780128019443
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Summary : Advances in Molecular Toxicology, Volume Thirteen, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest ...

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases
  • Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
  • Publisher : Springer
  • Release Date : 2016-09-20
  • Total pages : 496
  • ISBN : 9780128019443
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Summary : Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of ...

Using Old Solutions to New Problems

Using Old Solutions to New Problems
  • Author : Marianna Kulka
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-06-19
  • Total pages : 426
  • ISBN : 9780128019443
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Summary : The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a ...

Fundamentals of Neurodegeneration and Protein Misfolding Disorders

Fundamentals of Neurodegeneration and Protein Misfolding Disorders
  • Author : Martin Beckerman
  • Publisher : Springer
  • Release Date : 2015-11-06
  • Total pages : 378
  • ISBN : 9780128019443
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Summary : This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on ...

Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release Date : 2019-08-07
  • Total pages : 312
  • ISBN : 9780128019443
GET BOOK

Summary : Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on ...