Chemical Biology of the Genome

Written By Siddhartha Roy
Chemical Biology of the Genome
  • Publsiher : Academic Press
  • Release : 28 May 2021
  • ISBN : 0128176458
  • Pages : 350 pages
  • Rating : /5 from reviews
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Download or read book entitled Chemical Biology of the Genome by author: Siddhartha Roy which was release on 28 May 2021 and published by Academic Press with total page 350 pages . This book available in PDF, EPUB and Kindle Format. Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

Chemical Biology of the Genome

Chemical Biology of the Genome
  • Author : Siddhartha Roy,Tapas K. Kundu
  • Publisher : Academic Press
  • Release Date : 2021-05-28
  • Total pages : 350
  • ISBN : 0128176458
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Summary : Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance ...

Chemical Biology of Natural Products

Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher : CRC Press
  • Release Date : 2017-09-22
  • Total pages : 622
  • ISBN : 0128176458
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Summary : Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter ...

Advancing Development of Synthetic Gene Regulators

Advancing Development of Synthetic Gene Regulators
  • Author : Anandhakumar Chandran
  • Publisher : Springer
  • Release Date : 2017-09-19
  • Total pages : 114
  • ISBN : 0128176458
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Summary : This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class ...

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release Date : 2020-10-01
  • Total pages : 545
  • ISBN : 0128176458
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Summary : This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic ...

Chemical Genomics

Chemical Genomics
  • Author : Haian Fu
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 345
  • ISBN : 0128176458
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Summary : Advances in chemistry, biology, and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text with contributions from experts in the field discusses evolving concepts, essential techniques, and a wide range of applications to help further ...

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine
  • Author : Sheng Ding
  • Publisher : John Wiley & Sons
  • Release Date : 2008-02-08
  • Total pages : 272
  • ISBN : 0128176458
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Summary : Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, ...

Chemogenomics and Chemical Genetics

Chemogenomics and Chemical Genetics
  • Author : ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-21
  • Total pages : 256
  • ISBN : 0128176458
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Summary : Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new ...

Chemistry and the Human Genome

Chemistry and the Human Genome
  • Author : Ted Lister
  • Publisher : Royal Society of Chemistry
  • Release Date : 2002
  • Total pages : 46
  • ISBN : 0128176458
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Summary : This resource aims to show the chemical science behind the discovery for post-16 students of chemistry and biology, and places it in the context of science in the 21st century....

Drug Discovery from Natural Products

Drug Discovery from Natural Products
  • Author : Olga Genilloud,Francisca Vicente
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012-08-21
  • Total pages : 432
  • ISBN : 0128176458
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Summary : This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting ...

Chemical Synthetic Biology

Chemical Synthetic Biology
  • Author : Pier Luigi Luisi,Cristiano Chiarabelli
  • Publisher : John Wiley & Sons
  • Release Date : 2011-02-10
  • Total pages : 392
  • ISBN : 0128176458
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Summary : Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. ...

Chemical Genomics

Chemical Genomics
  • Author : Stefan Jaroch,Hilmar Weinmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-26
  • Total pages : 179
  • ISBN : 0128176458
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Summary : Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of ...

Data Mining in Drug Discovery

Data Mining in Drug Discovery
  • Author : Rémy D. Hoffmann,Arnaud Gohier,Pavel Pospisil
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-25
  • Total pages : 352
  • ISBN : 0128176458
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Summary : Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data ...

Chemical Genomics

Chemical Genomics
  • Author : Edward D. Zanders
  • Publisher : Humana Press
  • Release Date : 2010-10-28
  • Total pages : 280
  • ISBN : 0128176458
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Summary : Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical ...

Protein Targeting with Small Molecules

Protein Targeting with Small Molecules
  • Author : Hiroyuki Osada
  • Publisher : John Wiley & Sons
  • Release Date : 2009-07-31
  • Total pages : 312
  • ISBN : 0128176458
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Summary : Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug ...

Medicinal Plants

Medicinal Plants
  • Author : Hao Da,Xiao Jie Gu,Pei Gen Xiao
  • Publisher : Woodhead Publishing
  • Release Date : 2015-06-29
  • Total pages : 694
  • ISBN : 0128176458
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Summary : Medicinal Plants: Chemistry, Biology and Omics reviews the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plant tribes and genera, and their relevance to drug efficacy. Medicinal plants provide a myriad of pharmaceutically active components, which have been commonly used in traditional Chinese medicine and worldwide for thousands of ...