Cellular Senescence in Disease

Written By Manuel Serrano
Cellular Senescence in Disease
  • Publsiher : Academic Press
  • Release : 15 September 2021
  • ISBN : 9780128225141
  • Pages : 350 pages
  • Rating : /5 from reviews
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Download or read book entitled Cellular Senescence in Disease by author: Manuel Serrano which was release on 15 September 2021 and published by Academic Press with total page 350 pages . This book available in PDF, EPUB and Kindle Format. Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Cellular Senescence and Inflammation in Aging and Age related Disease

Cellular Senescence and Inflammation in Aging and Age related Disease
  • Author : Rijksuniversiteit Groningen
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 212
  • ISBN : 9780128225141
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Summary : Read online Cellular Senescence and Inflammation in Aging and Age related Disease written by Rijksuniversiteit Groningen, published by which was released on 2015. Download full Cellular Senescence and Inflammation in Aging and Age related Disease Books now! Available in PDF, ePub and Kindle....

Cellular Senescence in Disease

Cellular Senescence in Disease
  • Author : Manuel Serrano,Daniel Munos
  • Publisher : Academic Press
  • Release Date : 2021-09-15
  • Total pages : 350
  • ISBN : 9780128225141
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Summary : Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents ...

Senolytics in Disease Ageing and Longevity

Senolytics in Disease  Ageing and Longevity
  • Author : Daniel Muñoz-Espin,Marco Demaria
  • Publisher : Springer Nature
  • Release Date : 2020-04-27
  • Total pages : 222
  • ISBN : 9780128225141
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Summary : This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to ...

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
  • Author : Suresh I.S. Rattan,Leonard Hayflick
  • Publisher : Springer
  • Release Date : 2016-05-09
  • Total pages : 364
  • ISBN : 9780128225141
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Summary : This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells ...

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease
  • Author : Sofía Ferreira-González
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 9780128225141
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Summary : Read online Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease written by Sofía Ferreira-González, published by which was released on 2017. Download full Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease Books now! Available in PDF, ePub and Kindle....

Aging and Age Related Disorders

Aging and Age Related Disorders
  • Author : Stephen Bondy,Kenneth Maiese
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-02
  • Total pages : 472
  • ISBN : 9780128225141
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Summary : Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further ...

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases
  • Author : Ryusaku Matsumoto
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 212
  • ISBN : 9780128225141
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Summary : A number of observations suggest a close connection between telomere length and mortality and age-related disease, suggesting that telomere length is a useful marker of individual biological aging and the shortening of telomere length is causally related with the pathogenesis in age-related diseases. To date, the significance of telomere length ...

Tumor Dormancy Quiescence and Senescence Volume 2

Tumor Dormancy  Quiescence  and Senescence  Volume 2
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-29
  • Total pages : 320
  • ISBN : 9780128225141
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Summary : In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is ...

Aging and Age Related Disorders

Aging and Age Related Disorders
  • Author : Stephen Bondy,Kenneth Maiese
  • Publisher : Humana Press
  • Release Date : 2010-09-08
  • Total pages : 472
  • ISBN : 9780128225141
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Summary : Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further ...

Cellular Aging and Cell Death

Cellular Aging and Cell Death
  • Author : Nikki J. Holbrook,George R. Martin,Richard A. Lockshin
  • Publisher : John Wiley & Sons
  • Release Date : 1995-12-20
  • Total pages : 336
  • ISBN : 9780128225141
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Summary : Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation ...

Metabolic Interventions Delay Cellular Senescence

Metabolic Interventions Delay Cellular Senescence
  • Author : Timothy Nacarelli
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 432
  • ISBN : 9780128225141
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Summary : Cellular homeostasis is progressively diminished in multiple tissues during aging. Proliferation-arrested senescent cells accumulate within tissues and contribute towards reduced maintenance and repair and increased inflammation, a universal hallmark of age-related pathologies. Indeed, senescent cells are found at sites of age-related pathologies and thought to be a major contributor to ...

Senescence and Senescence Related Disorders

Senescence and Senescence Related Disorders
  • Author : Wang Zhiwei,Hiroyuki Inuzuka
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-02-20
  • Total pages : 160
  • ISBN : 9780128225141
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Summary : Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related ...

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer
  • Author : K. Lenhard Rudolph
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-11-07
  • Total pages : 330
  • ISBN : 9780128225141
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Summary : Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular ...

Autophagy and Senescence in Cancer Therapy

Autophagy and Senescence in Cancer Therapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-04-26
  • Total pages : 382
  • ISBN : 9780128225141
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Summary : Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in ...

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging
  • Author : Marco Malavolta,Eugenio Mocchegiani
  • Publisher : Academic Press
  • Release Date : 2016-04-15
  • Total pages : 784
  • ISBN : 9780128225141
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Summary : Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual ...