Carbohydrates in Drug Discovery and Development

Written By Vinod K. Tiwari
Carbohydrates in Drug Discovery and Development
  • Publsiher : Elsevier
  • Release : 31 July 2020
  • ISBN : 0128166762
  • Pages : 714 pages
  • Rating : /5 from reviews
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Download or read book entitled Carbohydrates in Drug Discovery and Development by author: Vinod K. Tiwari which was release on 31 July 2020 and published by Elsevier with total page 714 pages . This book available in PDF, EPUB and Kindle Format. Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development
  • Author : Vinod K. Tiwari
  • Publisher : Elsevier
  • Release Date : 2020-07-31
  • Total pages : 714
  • ISBN : 0128166762
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Summary : Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy ...

Carbohydrate based Drug Discovery

Carbohydrate based Drug Discovery
  • Author : Chi-Huey Wong
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • Total pages : 980
  • ISBN : 0128166762
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Summary : To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > ...

Carbohydrate based Drug Discovery 2 Volume Set

Carbohydrate based Drug Discovery  2 Volume Set
  • Author : Chi-Huey Wong
  • Publisher : John Wiley & Sons
  • Release Date : 2003-10-17
  • Total pages : 980
  • ISBN : 0128166762
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Summary : To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > ...

Carbohydrate Chemistry

Carbohydrate Chemistry
  • Author : Laura Cipolla
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 506
  • ISBN : 0128166762
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Summary : The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed ...

Chitin and Chitosan Derivatives

Chitin and Chitosan Derivatives
  • Author : Se-Kwon Kim
  • Publisher : CRC Press
  • Release Date : 2013-12-04
  • Total pages : 527
  • ISBN : 0128166762
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Summary : A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and ...

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2016-10-11
  • Total pages : 332
  • ISBN : 0128166762
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Summary : Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores ...

Carbohydrate Based Vaccines and Immunotherapies

Carbohydrate Based Vaccines and Immunotherapies
  • Author : Zhongwu Guo,Geert-Jan Boons
  • Publisher : John Wiley & Sons
  • Release Date : 2009-06-09
  • Total pages : 442
  • ISBN : 0128166762
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Summary : The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a ...

Carbohydrate Recognition

Carbohydrate Recognition
  • Author : Binghe Wang,Geert-Jan Boons
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Total pages : 440
  • ISBN : 0128166762
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Summary : This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high ...

Carbohydrates 2018

Carbohydrates 2018
  • Author : Amélia Pilar Rauter,Nuno Manuel Xavier
  • Publisher : MDPI
  • Release Date : 2020-03-25
  • Total pages : 172
  • ISBN : 0128166762
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Summary : This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds ...

Aminoglycoside Antibiotics

Aminoglycoside Antibiotics
  • Author : Dev P. Arya
  • Publisher : John Wiley & Sons
  • Release Date : 2007-06-29
  • Total pages : 336
  • ISBN : 0128166762
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Summary : Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the ...

Carbohydrate based Synthetic Methodology and Polymer Development

Carbohydrate based Synthetic Methodology and Polymer Development
  • Author : Vishwanath Venkatesh Gaitonde
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 165
  • ISBN : 0128166762
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Summary : Carbohydrates are some of the most abundant organic molecules on earth. They are ubiquitous compounds, most commonly known for providing energy for working and are biologically stockpiled as glycogen. Modern Era advancement in disciplines of glycomics, glycobiology, and bio-renewable studies has played a pivotal role in generating robust interest in ...

Influenza Virus Sialidase A Drug Discovery Target

Influenza Virus Sialidase   A Drug Discovery Target
  • Author : Mark Itzstein
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-09-01
  • Total pages : 178
  • ISBN : 0128166762
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Summary : Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects ...

Carbohydrate spiro heterocycles

Carbohydrate spiro heterocycles
  • Author : László Somsák
  • Publisher : Springer Nature
  • Release Date : 2019-10-26
  • Total pages : 295
  • ISBN : 0128166762
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Summary : This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. ...

The Organic Chemistry of Sugars

The Organic Chemistry of Sugars
  • Author : Taylor & Francis Group
  • Publisher : CRC Press
  • Release Date : 2021-06-30
  • Total pages : 904
  • ISBN : 0128166762
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Summary : Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains ...

Clinical Biochemistry and Drug Development

Clinical Biochemistry and Drug Development
  • Author : Shashank Kumar
  • Publisher : CRC Press
  • Release Date : 2020-11-01
  • Total pages : 264
  • ISBN : 0128166762
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Summary : This new volume focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development. The book introduces cell animal and bacterial culture techniques and their potential uses as well ...