Cancer Leading Proteases

Written By Satya Prakash Gupta
Cancer Leading Proteases
  • Publsiher : Academic Press
  • Release : 03 February 2020
  • ISBN : 0128181680
  • Pages : 526 pages
  • Rating : /5 from reviews
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Download or read book entitled Cancer Leading Proteases by author: Satya Prakash Gupta which was release on 03 February 2020 and published by Academic Press with total page 526 pages . This book available in PDF, EPUB and Kindle Format. Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Cancer Leading Proteases

Cancer Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2020-02-03
  • Total pages : 526
  • ISBN : 0128181680
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Summary : Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical ...

Matrix Proteases in Health and Disease

Matrix Proteases in Health and Disease
  • Author : Niels Behrendt
  • Publisher : John Wiley & Sons
  • Release Date : 2012-09-10
  • Total pages : 416
  • ISBN : 0128181680
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Summary : Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs ...

Proteases and Their Inhibitors in Cancer Metastasis

Proteases and Their Inhibitors in Cancer Metastasis
  • Author : J-M. Foidart,R.J. Muschel
  • Publisher : Springer Science & Business Media
  • Release Date : 2002
  • Total pages : 256
  • ISBN : 0128181680
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Summary : In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. ...

Liquid Biopsies of Solid Tumors

Liquid Biopsies of Solid Tumors
  • Author : Madumali Kalubowilage
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 0128181680
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Summary : Cancer is a group of diseases that are characterized by uncontrolled growth and spread of cells. In order to treat cancer successfully, it is important to diagnose cancers in their early stages, because survival often depends on the stage of cancer detection. For that purpose, highly sensitive and selective methods ...

Proteases in Human Diseases

Proteases in Human Diseases
  • Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release Date : 2017-07-13
  • Total pages : 513
  • ISBN : 0128181680
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Summary : This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role ...

Autophagy

Autophagy
  • Author : Jessica L. Schwartz-Roberts,Robert Clarke
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-09-03
  • Total pages : 440
  • ISBN : 0128181680
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Summary : Autophagy is a major catabolic process used by cells to remove superfluous or damaged proteins and organelles. In the final stages of autophagy, acidic organelles (lysosomes) act to degrade autophagic cargo and to facilitate their recycling. Little is known about how cancer cells undergoing autophagy, often as a consequence of ...

The Role of Force Generation in Metastatic Cancer Progression

The Role of Force Generation in Metastatic Cancer Progression
  • Author : Casey Marie Kraning-Rush
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 205
  • ISBN : 0128181680
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Summary : Metastasis, or the process by which cancer cells escape a primary tumor and travel through the body to form secondary tumors, is believed to be responsible for over 90% of the 7.9 million annual cancer-related fatalities reported worldwide. To migrate from the original tumor, cancer cells must navigate an extremely dense and ...

Development of Phosphoramidate Inhibitors for Cell Surface Proteases in Metastatic Cancers

Development of Phosphoramidate Inhibitors for Cell Surface Proteases in Metastatic Cancers
  • Author : Desiree Ellene Mendes
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 142
  • ISBN : 0128181680
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Summary : The development of highly tuned diagnostic agents are critical for the early detection of cancer and are commonly designed to bind cell surface receptors. A small library of first-generation phosphoramidate inhibitors leading to sub-micromolar potency as determined by a FRET-based spectrophotometric assay were generated as peptide mimics with a scaffold ...

National Railways of Mexico the Most Important Railway System in Mexico Extending from the United States to the Guatemalan Frontier

National Railways of Mexico  the Most Important Railway System in Mexico  Extending from the United States to the Guatemalan Frontier
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1931
  • Total pages : 8
  • ISBN : 0128181680
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Summary : Read online National Railways of Mexico the Most Important Railway System in Mexico Extending from the United States to the Guatemalan Frontier written by , published by which was released on 1931. Download full National Railways of Mexico the Most Important Railway System in Mexico Extending from the United States to the ...

Mother Child

Mother   Child
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1998
  • Total pages : 212
  • ISBN : 0128181680
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Summary : Read online Mother Child written by , published by which was released on 1998. Download full Mother Child Books now! Available in PDF, ePub and Kindle....

Bioengineered Technological Platforms for Quantitative Understanding of Cancer

Bioengineered Technological Platforms for Quantitative Understanding of Cancer
  • Author : Aereas Aung
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 200
  • ISBN : 0128181680
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Summary : In the United States, cancer is the second leading cause of death only to be surpassed by heart diseases (1). Within 2016, an estimated 1.6 million new cases of cancer will be diagnosed and approximately 0.6 million individuals will die from this disease (1). The survival rate of individuals afflicted with cancer have increased over ...

The Cancer Degradome

The Cancer Degradome
  • Author : Dylan Edwards,Gunilla Hoyer-Hansen,Francesco Blasi,B.F. Sloane
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-09-16
  • Total pages : 926
  • ISBN : 0128181680
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Summary : This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy....

Biological Chemistry

Biological Chemistry
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 212
  • ISBN : 0128181680
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Summary : Read online Biological Chemistry written by , published by which was released on 2004. Download full Biological Chemistry Books now! Available in PDF, ePub and Kindle....

The Role of Twist1 Mediated Induction of FAP alpha in Invadopodia and Breast Cancer Metastasis

The Role of Twist1 Mediated Induction of FAP alpha in Invadopodia and Breast Cancer Metastasis
  • Author : Navneeta Pathak
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 122
  • ISBN : 0128181680
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Summary : Breast cancer metastasis, the dissemination of primary tumor cells to distant organs, is the leading cause of death among breast cancer patients. During metastasis, tumor cells must invade through the basement membrane and local tissues, intravasate into the circulatory system, travel to a distant organ, extravasate into the new tissue, ...

The Role of Proprotein Convertases in Cancer

The Role of Proprotein Convertases in Cancer
  • Author : Xiaowei Sun
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 0128181680
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Summary : "Cancer is a leading cause of death worldwide and accounts for about one fifth of all death in the Western world. In 2008, nearly 12.7 million new cancer cases and 7.6 million cancer deaths occurred worldwide. The development of cancer is a multistage process, during which cells acquire a series of mutations that ...