Bursting Neurons and Fading Memories

Written By Michael R. D'Andrea
Bursting Neurons and Fading Memories
  • Publsiher : Academic Press
  • Release : 10 October 2014
  • ISBN : 0128019883
  • Pages : 170 pages
  • Rating : /5 from reviews
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Download or read book entitled Bursting Neurons and Fading Memories by author: Michael R. D'Andrea which was release on 10 October 2014 and published by Academic Press with total page 170 pages . This book available in PDF, EPUB and Kindle Format. Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release Date : 2014-10-10
  • Total pages : 170
  • ISBN : 0128019883
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Summary : Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with ...

Intracellular Consequences of Amyloid in Alzheimer s Disease

Intracellular Consequences of Amyloid in Alzheimer s Disease
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release Date : 2016-02-21
  • Total pages : 220
  • ISBN : 0128019883
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Summary : Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s ...

Alzheimer s Turning Point

Alzheimer   s Turning Point
  • Author : Jack C. de la Torre
  • Publisher : Springer
  • Release Date : 2016-06-25
  • Total pages : 251
  • ISBN : 0128019883
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Summary : This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a ...

Glia in Health and Disease

Glia in Health and Disease
  • Author : Tania Spohr
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-05-20
  • Total pages : 162
  • ISBN : 0128019883
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Summary : The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, ...

From Neuron to Cognition Via Computational Neuroscience

From Neuron to Cognition Via Computational Neuroscience
  • Author : Michael A. Arbib,James J. Bonaiuto
  • Publisher : MIT Press
  • Release Date : 2016-11-11
  • Total pages : 808
  • ISBN : 0128019883
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Summary : A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition....

Annual Editions

Annual Editions
  • Author : Karen L. Freiberg
  • Publisher : McGraw-Hill/Dushkin
  • Release Date : 2002-12
  • Total pages : 205
  • ISBN : 0128019883
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Summary : This annually updated reader is a compilation of carefully selected articles from magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others. This title is supported by Dushkin Online (www.dushkin.com/online/), a student Web site that ...

Advances in Natural Computation

Advances in Natural Computation
  • Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
  • Publisher : Springer
  • Release Date : 2006-09-28
  • Total pages : 992
  • ISBN : 0128019883
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Summary : This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural ...

Advances in Natural Computation

Advances in Natural Computation
  • Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-09-19
  • Total pages : 992
  • ISBN : 0128019883
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Summary : This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural ...

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
  • Author : Peter Whittle
  • Publisher : World Scientific Publishing Company
  • Release Date : 2010
  • Total pages : 244
  • ISBN : 0128019883
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Summary : Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an ...

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
  • Author : Peter Whittle
  • Publisher : World Scientific
  • Release Date : 2010-07-29
  • Total pages : 244
  • ISBN : 0128019883
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Summary : Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an ...

Advances in Neural Information Processing Systems 13

Advances in Neural Information Processing Systems 13
  • Author : Todd K. Leen,Thomas G. Dietterich,Volker Tresp
  • Publisher : MIT Press
  • Release Date : 2001
  • Total pages : 1106
  • ISBN : 0128019883
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Summary : The annual conference on Neural Information Processing Systems (NIPS) is the flagshipconference on neural computation. The conference is interdisciplinary, with contributions inalgorithms, learning theory, cognitive science, neuroscience, vision, speech and signal processing,reinforcement learning and control, implementations, and diverse applications. Only about 30 percentof the papers submitted are accepted for presentation ...

Knobil and Neill s Physiology of Reproduction

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  • Author : Tony M. Plant,Anthony J. Zeleznik
  • Publisher : Academic Press
  • Release Date : 2014-11-15
  • Total pages : 2684
  • ISBN : 0128019883
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Summary : The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of ...

Biological and Artificial Intelligence Environments

Biological and Artificial Intelligence Environments
  • Author : Bruno Apolloni,Maria Marinaro,Roberto Tagliaferri
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-11-04
  • Total pages : 406
  • ISBN : 0128019883
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Summary : Reports the proceedings of the 15th Italian workshop on neural networks issued by the Italian Society on Neural Networks SIREN. This volume contains papers in various fields, such as Pattern Recognition, Stochastic Optimization, Learning, Granular Computing, and more, with a bias toward bioinformatics operational applications....

Nature Inspired Problem Solving Methods in Knowledge Engineering

Nature Inspired Problem Solving Methods in Knowledge Engineering
  • Author : José Mira,José R. Álvarez
  • Publisher : Springer
  • Release Date : 2007-06-23
  • Total pages : 650
  • ISBN : 0128019883
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Summary : The second of a two-volume set, this book constitutes the refereed proceedings of the Second International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2007, held in La Manga del Mar Menor, Spain in June 2007. It contains all the contributions connected with biologically inspired methods and techniques for solving ...

Neuroscience for Clinicians

Neuroscience for Clinicians
  • Author : Eduardo E. Benarroch
  • Publisher : Oxford University Press
  • Release Date : 2021
  • Total pages : 832
  • ISBN : 0128019883
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Summary : "The aim of this book is to provide the clinician with a comprehensive and clinical relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms, at the molecular, cellular and system levels. The content of is based on the review of information ...