Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery

Written By Bowen Li
Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery
  • Publsiher : Unknown
  • Release : 17 April 2021
  • ISBN :
  • Pages : 237 pages
  • Rating : /5 from reviews
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Download or read book entitled Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery by author: Bowen Li which was release on 17 April 2021 and published by Unknown with total page 237 pages . This book available in PDF, EPUB and Kindle Format. The development of biotherapeutics, which hold promising potential to treat diverse disease, is limited by their inadequate circulation half-lives and inherent immunogenicity. Conjugation of non-ionic poly (ethylene glycol) (PEG), known as PEGylation, has been widely employed as the gold standard to ameliorate the pharmacokinetic (PK) and immunological profiles of proteins. Unfortunately, PEG grafted onto immunogenic proteins has been shown to induce anti-PEG antibodies (Abs) that could cause loss of efficacy and even lethal adverse reactions. To confront the "PEG dilemma", zwitterionic materials with superhydrophilicity are emerging as promising alternatives for PEG. This dissertation summarizes recent studies from the design, synthesis and characterization of zwitterionic polymers to the in vitro and in vivo studies of poly(zwitterion)- protein nanomedicine. The influence of PEG and zwitterionic poly(carboxy betaine) (PCB) on immune systems is firstly discussed, revealing the low immunogenic risk of zwitterionic materials. Based on this design principle, new protein-delivery tactics are proposed to avoid the generation of undesirable immune responses, either by completely shielding proteins from immune recognition or by actively inducing antigen-specific immune tolerance. Furthermore, new classes of naturally-inspired inert or immunomodulatory zwitterionic materials are developed to further improve the efficacy and safety of protein therapeutics, enriching the arsenal of biomaterial tools for drug delivery.

Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery

Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery
  • Author : Bowen Li
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 237
  • ISBN :
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Summary : The development of biotherapeutics, which hold promising potential to treat diverse disease, is limited by their inadequate circulation half-lives and inherent immunogenicity. Conjugation of non-ionic poly (ethylene glycol) (PEG), known as PEGylation, has been widely employed as the gold standard to ameliorate the pharmacokinetic (PK) and immunological profiles of proteins. ...

Biomaterials and Immune Response

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  • Author : Nihal Engin Vrana
  • Publisher : CRC Press
  • Release Date : 2018-07-20
  • Total pages : 249
  • ISBN :
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Summary : The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking ...

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  • Publisher : John Wiley & Sons
  • Release Date : 2003-04-14
  • Total pages : 248
  • ISBN :
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Summary : An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance ...

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  • Publisher : Woodhead Publishing
  • Release Date : 2021-07-15
  • Total pages : 345
  • ISBN :
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Summary : Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune ...

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  • Publisher : Bentham Science Publishers
  • Release Date : 2017-10-03
  • Total pages : 310
  • ISBN :
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Summary : This volume reviews the published knowledge about bioactive composites, protein scaffolds and hydrogels. Chapters also detail the production parameters and clarify the evaluation protocol for analysis or testing and scaffolding biomaterials. The volume concludes with a summary of applications of porous scaffold in medicine. Each chapter links basic scientific and ...

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  • Publisher : CRC Press
  • Release Date : 2008-05-28
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  • ISBN :
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Summary : Written by more than 400 subject experts representing diverse academic and applied domains, this multidisciplinary resource surveys the vanguard of biomaterials and biomedical engineering technologies utilizing biomaterials that lead to quality-of-life improvements. Building on traditional engineering principles, it serves to bridge advances in mat...

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  • Author : John Enderle, Ph.D.,Joseph Bronzino,Susan M. Blanchard
  • Publisher : Academic Press
  • Release Date : 2005-04-20
  • Total pages : 1118
  • ISBN :
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Summary : Since publication in 1999, the first edition of Introduction to Biomedical Engineering has dominated the market of biomedical engineering texts. Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with ...

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Summary : The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in ...

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  • Publisher : John Wiley & Sons
  • Release Date : 2014-04-14
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Summary : This book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine. Scientists, engineers and physicians are working together to replicate the sophisticated hierarchical organization and adaptability ...

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  • Author : Buddy D. Ratner
  • Publisher : Academic Press
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  • ISBN :
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Summary : "... This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue ...

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  • Release Date : 2014-11-05
  • Total pages : 932
  • ISBN :
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Summary : Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem ...

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  • Release Date : 2018-11-23
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Summary : This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction ...

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  • Author : Trans Tech Publications, Limited
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  • ISBN :
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Summary : The 36th volume of Journal of Biomimetics, Biomaterials and Biomedical Engineering includes papers that describe the results of scientific research and of some applied aspects in the fields of biomechanics, dental implantation, and utilization of modern biomaterials and some new research methods in the current biomedical practice. We hope that ...

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  • Publisher : Unknown
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Summary : Read online Tissue Engineering written by , published by which was released on 2008. Download full Tissue Engineering Books now! Available in PDF, ePub and Kindle....

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  • Publisher : Academic Press
  • Release Date : 2017-07-05
  • Total pages : 224
  • ISBN :
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Summary : Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with ...