Basic Principles of Drug Discovery and Development

Written By Benjamin Blass
Basic Principles of Drug Discovery and Development
  • Publsiher : Elsevier
  • Release : 24 April 2015
  • ISBN : 012411525X
  • Pages : 580 pages
  • Rating : /5 from reviews
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Download or read book entitled Basic Principles of Drug Discovery and Development by author: Benjamin Blass which was release on 24 April 2015 and published by Elsevier with total page 580 pages . This book available in PDF, EPUB and Kindle Format. Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin Blass
  • Publisher : Elsevier
  • Release Date : 2015-04-24
  • Total pages : 580
  • ISBN : 012411525X
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Summary : Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in ...

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Release Date : 2020-11-15
  • Total pages : 750
  • ISBN : 012411525X
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Summary : Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, one that requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians and a host of experts from numerous additional fields. Enabling technologies ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
  • Publisher : Academic Press
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 012411525X
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Summary : Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the ...

Principles of CNS Drug Development

Principles of CNS Drug Development
  • Author : John Kelly
  • Publisher : John Wiley & Sons
  • Release Date : 2009-10-27
  • Total pages : 324
  • ISBN : 012411525X
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Summary : This title acts as a primer, giving students and newcomers to the field an opportunity to learn about the breadth of the CNS drug discovery. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in ...

Plant Bioactives and Drug Discovery

Plant Bioactives and Drug Discovery
  • Author : Valdir Cechinel-Filho
  • Publisher : John Wiley & Sons
  • Release Date : 2012-05-22
  • Total pages : 565
  • ISBN : 012411525X
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Summary : An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform ...

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Release Date : 2021-05-25
  • Total pages : 712
  • ISBN : 012411525X
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Summary : Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such ...

Oral Bioavailability

Oral Bioavailability
  • Author : Xiaoling Li
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-04
  • Total pages : 560
  • ISBN : 012411525X
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Summary : Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, ...

General and Molecular Pharmacology

General and Molecular Pharmacology
  • Author : Francesco Clementi,Guido Fumagalli
  • Publisher : John Wiley & Sons
  • Release Date : 2015-07-01
  • Total pages : 784
  • ISBN : 012411525X
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Summary : With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and ...

Mass Spectrometry in Drug Metabolism and Disposition

Mass Spectrometry in Drug Metabolism and Disposition
  • Author : Mike S. Lee,Mingshe Zhu
  • Publisher : John Wiley & Sons
  • Release Date : 2011-03-16
  • Total pages : 800
  • ISBN : 012411525X
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Summary : This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine ...

Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition

Molecular Imaging  Basic Principles And Applications In Biomedical Research  3rd Edition
  • Author : Markus Rudin
  • Publisher : World Scientific
  • Release Date : 2020-04-04
  • Total pages : 800
  • ISBN : 012411525X
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Summary : The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full ...

Molecular Imaging Basic Principles And Applications In Biomedical Research 2nd Edition

Molecular Imaging  Basic Principles And Applications In Biomedical Research  2nd Edition
  • Author : Rudin Markus
  • Publisher : World Scientific
  • Release Date : 2013-07-04
  • Total pages : 620
  • ISBN : 012411525X
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Summary : The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full ...

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release Date : 2013-10-31
  • Total pages : 622
  • ISBN : 012411525X
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Summary : This book features the latest on the design and development of new anticancer small molecules, including topics such as the identification of molecular targets, cancer genomics, and personalized medicine....

Drug Discovery and Development Volume 1

Drug Discovery and Development  Volume 1
  • Author : Mukund S. Chorghade
  • Publisher : Wiley-Interscience
  • Release Date : 2006-06-16
  • Total pages : 476
  • ISBN : 012411525X
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Summary : This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents ...

Pharmacokinetics in Drug Discovery and Development

Pharmacokinetics in Drug Discovery and Development
  • Author : Ronald D. Schoenwald
  • Publisher : CRC Press
  • Release Date : 2002-03-06
  • Total pages : 440
  • ISBN : 012411525X
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Summary : Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the ...

Pharmacokinetics and Metabolism in Drug Design

Pharmacokinetics and Metabolism in Drug Design
  • Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
  • Publisher : John Wiley & Sons
  • Release Date : 2006-05-01
  • Total pages : 207
  • ISBN : 012411525X
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Summary : In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant ...