Astrocytes and Epilepsy

Written By Jacqueline A. Hubbard
Astrocytes and Epilepsy
  • Publsiher : Academic Press
  • Release : 05 July 2016
  • ISBN : 0128026243
  • Pages : 394 pages
  • Rating : /5 from reviews
GET THIS BOOKAstrocytes and Epilepsy


Download or read book entitled Astrocytes and Epilepsy by author: Jacqueline A. Hubbard which was release on 05 July 2016 and published by Academic Press with total page 394 pages . This book available in PDF, EPUB and Kindle Format. Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release Date : 2016-07-05
  • Total pages : 394
  • ISBN : 0128026243
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Summary : Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". ...

Crucial Role for Astrocytes in Epilepsy

Crucial Role for Astrocytes in Epilepsy
  • Author : Peter Bedner,Christian Steinhäuser
  • Publisher : Biota Publishing
  • Release Date : 2015-08-01
  • Total pages : 89
  • ISBN : 0128026243
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Summary : This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies ...

Examining the Role of Astrocyte Swelling and Swelling induced Glutamate Release in Two Models of Neuronal Hyperexcitability

Examining the Role of Astrocyte Swelling and Swelling induced Glutamate Release in Two Models of Neuronal Hyperexcitability
  • Author : Thomas Robert Murphy
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 160
  • ISBN : 0128026243
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Summary : Epilepsy, a spectrum of over 40 different disorders, is estimated to affect 1 in 26 people worldwide. It is generally characterized by the appearance of spontaneous, recurrent and unpredictable seizures. Approximately one-third of epileptic patients cannot control their seizures with current medications, while the remaining two-thirds of patients often experience negative cognitive side ...

Functional Properties of Reactive Astrocytes in an Animal Model of Epilepsy

Functional Properties of Reactive Astrocytes in an Animal Model of Epilepsy
  • Author : D. Koji Takahashi
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 334
  • ISBN : 0128026243
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Summary : Read online Functional Properties of Reactive Astrocytes in an Animal Model of Epilepsy written by D. Koji Takahashi, published by which was released on 2009. Download full Functional Properties of Reactive Astrocytes in an Animal Model of Epilepsy Books now! Available in PDF, ePub and Kindle....

Astrocytes in Patho Physiology of the Nervous System

Astrocytes in  Patho Physiology of the Nervous System
  • Author : Vladimir Parpura,Philip G. Haydon
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-11
  • Total pages : 738
  • ISBN : 0128026243
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Summary : Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with ...

Seizure Induced Gliogenesis in the Piriform Cortex microform

Seizure Induced Gliogenesis in the Piriform Cortex  microform
  • Author : Mani Vessal
  • Publisher : Library and Archives Canada = Bibliothèque et Archives Canada
  • Release Date : 2004
  • Total pages : 404
  • ISBN : 0128026243
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Summary : Complex partial epilepsy is a seizure disorder in which attacks frequently arise from foci located in the temporal lobes. The amygdala-kindling model is a widely used model of complex partial epilepsy with secondary generalization. The present study was designed to (1) quantitatively assess astrocytic changes in the rat piriform cortex in ...

Epilepsy

Epilepsy
  • Author : Mary A. B. Brazier
  • Publisher : Academic Press
  • Release Date : 2014-06-28
  • Total pages : 404
  • ISBN : 0128026243
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Summary : Epilepsy: Its Phenomena in Man is a 16-chapter text that covers the wide field of the phenomena of epilepsy in man. This book emerged from the manuscripts presented by the scientific program of an alumni reunion of the Brain Research Institute of the University of California, Los Angeles. The introductory ...

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
  • Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
  • Publisher : Academic Press
  • Release Date : 2017-06-14
  • Total pages : 1178
  • ISBN : 0128026243
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Summary : Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in ...

Epilepsy as a Dynamic Disease

Epilepsy as a Dynamic Disease
  • Author : John Milton,Peter Jung
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-17
  • Total pages : 417
  • ISBN : 0128026243
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Summary : The first book to bring together experts in epilepsy, bio-engineering and dynamical systems theory, to discuss the possibility of treating epilepsy by controlling mechanisms that cause seizures. It includes a unique reference database with more than 1000 references, including hard-to-access references in the Russian literature....

Novel Viral and Astrocytic Contributors to Epilepsy

Novel Viral and Astrocytic Contributors to Epilepsy
  • Author : Julie Chen
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 262
  • ISBN : 0128026243
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Summary : Epilepsy is a neurological seizure disorder affecting approximately 1% of the world's population. Seizure disorders are numerous, heterogeneous, and can develop from a multitude of physiological conditions including but not limited to interneuron dysfunction, ion channel mutations, irregular development and layering of the cerebral cortex, abnormalities in cell signaling pathways, brain ...

Encyclopedia of Basic Epilepsy Research

Encyclopedia of Basic Epilepsy Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2009-05-27
  • Total pages : 1832
  • ISBN : 0128026243
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Summary : As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of ...

Neuropathology of Epilepsy

Neuropathology of Epilepsy
  • Author : Francesco Scaravilli
  • Publisher : World Scientific
  • Release Date : 1998
  • Total pages : 599
  • ISBN : 0128026243
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Summary : Health Onlineturns a computer into your most important health tool. For newcomers, it makes going online easy by explaining e-mail and showing what’s on the big commercial online services. Later chapters explore Internet mailing lists, newsgroups, and World Wide Web pages. Even online veterans will benefit from the book’...

Clinical and Genetic Aspects of Epilepsy

Clinical and Genetic Aspects of Epilepsy
  • Author : Zaid Afawi
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-09-15
  • Total pages : 216
  • ISBN : 0128026243
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Summary : This book on Epilepsy was conceived and produced as a source of information on wide range of issues in epilepsy. We hope that it will help health care providers in daily practices and increase their understanding on diagnosis and treatment of epilepsies. The book was designed as an update for ...

Characterization of Human Astrocytes Cultured from Tumor Related Neocortical Seizure Foci

Characterization of Human Astrocytes Cultured from Tumor Related Neocortical Seizure Foci
  • Author : Subu Magge
  • Publisher : Unknown
  • Release Date : 1993
  • Total pages : 204
  • ISBN : 0128026243
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Summary : Read online Characterization of Human Astrocytes Cultured from Tumor Related Neocortical Seizure Foci written by Subu Magge, published by which was released on 1993. Download full Characterization of Human Astrocytes Cultured from Tumor Related Neocortical Seizure Foci Books now! Available in PDF, ePub and Kindle....

Morphological and Functional Alterations of Astrocytes Following Experimentally Induced Epilepsy

Morphological and Functional Alterations of Astrocytes Following Experimentally Induced Epilepsy
  • Author : Jay R. Vargas
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 104
  • ISBN : 0128026243
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Summary : Read online Morphological and Functional Alterations of Astrocytes Following Experimentally Induced Epilepsy written by Jay R. Vargas, published by which was released on 2011. Download full Morphological and Functional Alterations of Astrocytes Following Experimentally Induced Epilepsy Books now! Available in PDF, ePub and Kindle....