Antibody Fc

Written By Margaret Ackerman
Antibody Fc
  • Publsiher : Academic Press
  • Release : 06 August 2013
  • ISBN : 0123948185
  • Pages : 358 pages
  • Rating : /5 from reviews
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Download or read book entitled Antibody Fc by author: Margaret Ackerman which was release on 06 August 2013 and published by Academic Press with total page 358 pages . This book available in PDF, EPUB and Kindle Format. Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

Antibody Fc

Antibody Fc
  • Author : Margaret Ackerman,Falk Nimmerjahn
  • Publisher : Academic Press
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume ...

Antibody Fc

Antibody Fc
  • Author : Mattias Collin,Mogens Kilian
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector ...

Antibody Fc

Antibody Fc
  • Author : Victor Raúl Gómez Román,Joseph C. Murray,Louis M. Weiner
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Antibody-dependent cellular cytotoxicity (ADCC), also called antibody-dependent cell-mediated cytotoxicity, is an immune mechanism through which Fc receptor-bearing effector cells can recognize and kill antibody-coated target cells expressing tumor- or pathogen-derived antigens on their surface. Numerous associations between ADCC activity, Fc receptor polymorphisms, and clinical outcomes have been observed in both ...

Antibody Fc

Antibody Fc
  • Author : Theo Rispens,Gestur Vidarsson
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Immunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate. In humans, there are five classes of immunoglobulins, which differ in heavy-chain structure. Immunoglobulin G (IgG) is the major class of immunoglobulins in blood and can be further subdivided in subclasses. The four subclasses of ...

Antibody Fc

Antibody Fc
  • Author : Xiaojie Yu,Kavitha Baruah,Christopher N. Scanlan,Max Crispin
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : The antibody Fc region is posttranslationally modified by N-linked glycosylation. In immunoglobulin G (IgG), the processing of the glycans is restricted by the presence of extensive interaction with the protein surface. The resulting set of antibody glycoforms exhibit a range of effector functions. In this chapter, we outline the impact ...

Fc Localized Secondary Forces in Antigen antibody Precipitation

Fc Localized Secondary Forces in Antigen antibody Precipitation
  • Author : John D. Rodwell
  • Publisher : Unknown
  • Release Date : 1976
  • Total pages : 312
  • ISBN : 0123948185
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Summary : Read online Fc Localized Secondary Forces in Antigen antibody Precipitation written by John D. Rodwell, published by which was released on 1976. Download full Fc Localized Secondary Forces in Antigen antibody Precipitation Books now! Available in PDF, ePub and Kindle....

Antibody Fc

Antibody Fc
  • Author : Roy Jefferis
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Diversity of antigen-binding specificity may be considered the hallmark of antibodies; however, the human IgG-Fc region also exhibits binding specificity for multiple ligands. Evolution of the IgG-Fc has resulted in the generation of interaction sites for endogenous (self) ligands that recruit and activate mechanisms facilitating the removal and destruction of ...

Antibody Fc

Antibody Fc
  • Author : Falk Nimmerjahn
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Autoimmune disorders are characterized by the destruction of self-tissues by the immune system. Multiple checkpoints are in place to prevent autoreactivity under normal circumstances. Co-expression of activating and inhibitory Fc receptors (FcRs) represents such a checkpoint by establishing a threshold for immune cell activation. In many human autoimmune diseases, however, ...

Antibody Fc Engineering Towards Better Therapeutics

Antibody Fc Engineering  Towards Better Therapeutics
  • Author : Tianlei Ying,Rui Gong
  • Publisher : Frontiers Media SA
  • Release Date : 2018-12-21
  • Total pages : 212
  • ISBN : 0123948185
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Summary : Read online Antibody Fc Engineering Towards Better Therapeutics written by Tianlei Ying,Rui Gong, published by Frontiers Media SA which was released on 2018-12-21. Download full Antibody Fc Engineering Towards Better Therapeutics Books now! Available in PDF, ePub and Kindle....

Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen PSCA Expressing Xenografts in Vivo by MicroPET

Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen  PSCA   Expressing Xenografts in Vivo by MicroPET
  • Author : Victor Jeffrey Leyton
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 526
  • ISBN : 0123948185
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Summary : Read online Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen PSCA Expressing Xenografts in Vivo by MicroPET written by Victor Jeffrey Leyton, published by which was released on 2008. Download full Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen PSCA Expressing ...

Studies on the Specificity of Human Anti immunoglobulin G Antibodies

Studies on the Specificity of Human Anti immunoglobulin G Antibodies
  • Author : Sharon Hunt Gerardo
  • Publisher : Unknown
  • Release Date : 1990
  • Total pages : 208
  • ISBN : 0123948185
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Summary : Read online Studies on the Specificity of Human Anti immunoglobulin G Antibodies written by Sharon Hunt Gerardo, published by which was released on 1990. Download full Studies on the Specificity of Human Anti immunoglobulin G Antibodies Books now! Available in PDF, ePub and Kindle....

Human IgG Fc Receptors

Human IgG Fc Receptors
  • Author : Jan G Vande Winkel,Peter J. A. Capel
  • Publisher : Landes Bioscience
  • Release Date : 1996
  • Total pages : 241
  • ISBN : 0123948185
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Summary : Fc receptors in human placenta/human Fc receptors: ligand interactions/Fc receptors on platelets/soluble Fc receptors....

Activation of Antibody Synthesis in Human B Lymphocytes

Activation of Antibody Synthesis in Human B Lymphocytes
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1979
  • Total pages : 305
  • ISBN : 0123948185
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Summary : Read online Activation of Antibody Synthesis in Human B Lymphocytes written by , published by which was released on 1979. Download full Activation of Antibody Synthesis in Human B Lymphocytes Books now! Available in PDF, ePub and Kindle....

The Journal of Immunology

The Journal of Immunology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1989
  • Total pages : 212
  • ISBN : 0123948185
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Summary : Read online The Journal of Immunology written by , published by which was released on 1989. Download full The Journal of Immunology Books now! Available in PDF, ePub and Kindle....

Antibodies Complement Vaccines

Antibodies  Complement  Vaccines
  • Author : P. Gronski
  • Publisher : Unknown
  • Release Date : 1984
  • Total pages : 173
  • ISBN : 0123948185
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Summary : Read online Antibodies Complement Vaccines written by P. Gronski, published by which was released on 1984. Download full Antibodies Complement Vaccines Books now! Available in PDF, ePub and Kindle....