An Innovative Approach to Understanding and Treating Cancer Targeting pH

Written By Tomas Koltai
An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Publsiher : Academic Press
  • Release : 16 January 2020
  • ISBN : 0128190604
  • Pages : 574 pages
  • Rating : /5 from reviews
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer Targeting pH


Download or read book entitled An Innovative Approach to Understanding and Treating Cancer Targeting pH by author: Tomas Koltai which was release on 16 January 2020 and published by Academic Press with total page 574 pages . This book available in PDF, EPUB and Kindle Format. An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release Date : 2020-01-16
  • Total pages : 574
  • ISBN : 0128190604
GET BOOK

Summary : An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of ...

Cancer Research Program Annual Report to the California State Legislature

Cancer Research Program Annual Report to the California State Legislature
  • Author : Cancer Research Program (Calif.)
  • Publisher : Unknown
  • Release Date : 2000
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Cancer Research Program Annual Report to the California State Legislature written by Cancer Research Program (Calif.), published by which was released on 2000. Download full Cancer Research Program Annual Report to the California State Legislature Books now! Available in PDF, ePub and Kindle....

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1997
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Cumulated Index Medicus written by , published by which was released on 1997. Download full Cumulated Index Medicus Books now! Available in PDF, ePub and Kindle....

Prostate Cancer Metabolism

Prostate Cancer Metabolism
  • Author : Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel
  • Publisher : Academic Press
  • Release Date : 2021-07-01
  • Total pages : 200
  • ISBN : 0128190604
GET BOOK

Summary : Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard ...

Wiley Encyclopedia of Chemical Biology Volume 3

Wiley Encyclopedia of Chemical Biology  Volume 3
  • Author : Tadhg P. Begley
  • Publisher : Wiley
  • Release Date : 2009-02-03
  • Total pages : 828
  • ISBN : 0128190604
GET BOOK

Summary : The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the ...

Genetic Engineering News

Genetic Engineering News
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Genetic Engineering News written by , published by which was released on 2005. Download full Genetic Engineering News Books now! Available in PDF, ePub and Kindle....

Journal of the National Cancer Institute

Journal of the National Cancer Institute
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1992-05
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Journal of the National Cancer Institute written by , published by which was released on 1992-05. Download full Journal of the National Cancer Institute Books now! Available in PDF, ePub and Kindle....

New Scientist

New Scientist
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online New Scientist written by , published by which was released on 2009. Download full New Scientist Books now! Available in PDF, ePub and Kindle....

Dissertation Abstracts International

Dissertation Abstracts International
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Dissertation Abstracts International written by , published by which was released on 2008. Download full Dissertation Abstracts International Books now! Available in PDF, ePub and Kindle....

International Journal of Oncology

International Journal of Oncology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online International Journal of Oncology written by , published by which was released on 2007. Download full International Journal of Oncology Books now! Available in PDF, ePub and Kindle....

Abstracts

Abstracts
  • Author : American Public Health Association. Annual Meeting
  • Publisher : Unknown
  • Release Date : 1992
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Abstracts written by American Public Health Association. Annual Meeting, published by which was released on 1992. Download full Abstracts Books now! Available in PDF, ePub and Kindle....

Comprehensive Dissertation Index

Comprehensive Dissertation Index
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1989
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Comprehensive Dissertation Index written by , published by which was released on 1989. Download full Comprehensive Dissertation Index Books now! Available in PDF, ePub and Kindle....

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by , published by which was released on 2007. Download full Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great ...

Acta Cytologica

Acta Cytologica
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Includes abstracts of papers of various symposia...

Advances in Breast Cancer Research

Advances in Breast Cancer Research
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2003
  • Total pages : 212
  • ISBN : 0128190604
GET BOOK

Summary : Read online Advances in Breast Cancer Research written by , published by which was released on 2003. Download full Advances in Breast Cancer Research Books now! Available in PDF, ePub and Kindle....