AGO Driven Non Coding RNAs

Written By Bibekanand Mallick
AGO Driven Non Coding RNAs
  • Publsiher : Academic Press
  • Release : 20 January 2019
  • ISBN : 0128156708
  • Pages : 387 pages
  • Rating : /5 from reviews
GET THIS BOOKAGO Driven Non Coding RNAs


Download or read book entitled AGO Driven Non Coding RNAs by author: Bibekanand Mallick which was release on 20 January 2019 and published by Academic Press with total page 387 pages . This book available in PDF, EPUB and Kindle Format. The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

AGO Driven Non Coding RNAs

AGO Driven Non Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Total pages : 387
  • ISBN : 0128156708
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Summary : The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily ...

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher : Springer Nature
  • Release Date : 2020-03-20
  • Total pages : 499
  • ISBN : 0128156708
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Summary : This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent ...

Non coding RNAs and Cancer

Non coding RNAs and Cancer
  • Author : Muller Fabbri
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-28
  • Total pages : 284
  • ISBN : 0128156708
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Summary : The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of ...

Long Non Coding RNAs and Immunity

Long Non Coding RNAs and Immunity
  • Author : Adam Williams,Jorge Henao-Mejia
  • Publisher : Frontiers Media SA
  • Release Date : 2021-06-29
  • Total pages : 212
  • ISBN : 0128156708
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Summary : We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased ...

Regulatory RNAs in the Nervous System 2nd Edition

Regulatory RNAs in the Nervous System  2nd Edition
  • Author : Tommaso Pizzorusso,Alessandro Cellerino,Laure Bally-Cuif
  • Publisher : Frontiers Media SA
  • Release Date : 2018-11-13
  • Total pages : 346
  • ISBN : 0128156708
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Summary : Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory ...

Micro RNAs in Cancer

Micro RNAs in Cancer
  • Author : Feng Yu
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 206
  • ISBN : 0128156708
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Summary : Non-coding RNAs have become a hot topic of cancer research in recent decades, with miRNAs being probably the most active area of research. However, the functions of short non-coding RNA (ncRNA) fragments commonly existing in cells remains less understood. Herein we explore the novel ncRNAs which play a role in ...

Regulation by non coding RNAs Volume 1

Regulation by non coding RNAs Volume 1
  • Author : Nicholas Delihas
  • Publisher : MDPI
  • Release Date : 2018-10-09
  • Total pages : 850
  • ISBN : 0128156708
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Summary : Printed Edition of the Special Issue Published in IJMS...

Long Non coding RNAs in Human Disease

Long Non coding RNAs in Human Disease
  • Author : Kevin V. Morris
  • Publisher : Springer
  • Release Date : 2016-04-13
  • Total pages : 262
  • ISBN : 0128156708
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Summary : This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play ...

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release Date : 2017-10-13
  • Total pages : 576
  • ISBN : 0128156708
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Summary : Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and ...

The Long and Short Non coding RNAs in Cancer Biology

The Long and Short Non coding RNAs in Cancer Biology
  • Author : Erwei Song
  • Publisher : Springer
  • Release Date : 2016-07-04
  • Total pages : 458
  • ISBN : 0128156708
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Summary : The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in ...

Non coding RNA and the Reproductive System

Non coding RNA and the Reproductive System
  • Author : Dagmar Wilhelm,Pascal Bernard
  • Publisher : Springer
  • Release Date : 2015-12-11
  • Total pages : 198
  • ISBN : 0128156708
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Summary : This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, ...

Regulation of Soluble Immune Mediators by Non Coding RNAs

Regulation of Soluble Immune Mediators by Non Coding RNAs
  • Author : Flavia Bazzoni,Daniela Bosisio
  • Publisher : Frontiers Media SA
  • Release Date : 2020-12-11
  • Total pages : 212
  • ISBN : 0128156708
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Summary : Read online Regulation of Soluble Immune Mediators by Non Coding RNAs written by Flavia Bazzoni,Daniela Bosisio, published by Frontiers Media SA which was released on 2020-12-11. Download full Regulation of Soluble Immune Mediators by Non Coding RNAs Books now! Available in PDF, ePub and Kindle....

The Orchid Genome

The Orchid Genome
  • Author : Fure-Chyi Chen
  • Publisher : Springer Nature
  • Release Date : 2021-07-24
  • Total pages : 212
  • ISBN : 0128156708
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Summary : Read online The Orchid Genome written by Fure-Chyi Chen, published by Springer Nature which was released on . Download full The Orchid Genome Books now! Available in PDF, ePub and Kindle....

Non coding RNAs in Colorectal Cancer

Non coding RNAs in Colorectal Cancer
  • Author : Ondrej Slaby,George A. Calin
  • Publisher : Springer
  • Release Date : 2016-08-29
  • Total pages : 252
  • ISBN : 0128156708
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Summary : This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of ...

Non coding RNAs in Cardiovascular Diseases

Non coding RNAs in Cardiovascular Diseases
  • Author : Junjie Xiao
  • Publisher : Springer Nature
  • Release Date : 2020-04-13
  • Total pages : 426
  • ISBN : 0128156708
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Summary : This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is ...