Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Written By Surendra Nimesh
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
  • Publsiher : Woodhead Publishing
  • Release : 04 April 2017
  • ISBN : 0081005636
  • Pages : 256 pages
  • Rating : /5 from reviews
GET THIS BOOKAdvances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids


Download or read book entitled Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids by author: Surendra Nimesh which was release on 04 April 2017 and published by Woodhead Publishing with total page 256 pages . This book available in PDF, EPUB and Kindle Format. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
  • Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
  • Publisher : Woodhead Publishing
  • Release Date : 2017-04-04
  • Total pages : 256
  • ISBN : 0081005636
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Summary : Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive ...

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  • ISBN : 0081005636
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Summary : Read online Advances in Material Design for Regenerative Medicine Drug Delivery and Targeting imaging written by V. Prasad Shastri, published by which was released on 2009. Download full Advances in Material Design for Regenerative Medicine Drug Delivery and Targeting imaging Books now! Available in PDF, ePub and Kindle....

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