A Practical Guide to Rational Drug Design

Written By Sun Hongmao
A Practical Guide to Rational Drug Design
  • Publsiher : Woodhead Publishing
  • Release : 01 October 2015
  • ISBN : 9780081000984
  • Pages : 292 pages
  • Rating : /5 from reviews
GET THIS BOOKA Practical Guide to Rational Drug Design


Download or read book entitled A Practical Guide to Rational Drug Design by author: Sun Hongmao which was release on 01 October 2015 and published by Woodhead Publishing with total page 292 pages . This book available in PDF, EPUB and Kindle Format. This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. Discusses various tactics applicable to daily drug design Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops Offers a unique viewpoint on drug discovery research due to the author's cross-discipline education background Explores the author's rich experiences in both pharmaceutical and academic settings

A Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design
  • Author : Sun Hongmao
  • Publisher : Woodhead Publishing
  • Release Date : 2015-10-01
  • Total pages : 292
  • ISBN : 9780081000984
GET BOOK

Summary : This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high ...

A Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design
  • Author : Sun Hongmao
  • Publisher : Woodhead Publishing
  • Release Date : 2015-10-05
  • Total pages : 292
  • ISBN : 9780081000984
GET BOOK

Summary : This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high ...

Big Data Machine Learning and Applications

Big Data  Machine Learning  and Applications
  • Author : Ripon Patgiri
  • Publisher : Springer Nature
  • Release Date : 2021-08-04
  • Total pages : 212
  • ISBN : 9780081000984
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Summary : Read online Big Data Machine Learning and Applications written by Ripon Patgiri, published by Springer Nature which was released on . Download full Big Data Machine Learning and Applications Books now! Available in PDF, ePub and Kindle....

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design
  • Author : Sanjeev Kumar Singh
  • Publisher : Springer Nature
  • Release Date : 2021-08-04
  • Total pages : 212
  • ISBN : 9780081000984
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Summary : Read online Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design written by Sanjeev Kumar Singh, published by Springer Nature which was released on . Download full Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design Books now! Available in PDF, ePub and ...

Computational Chemistry

Computational Chemistry
  • Author : David Young
  • Publisher : John Wiley & Sons
  • Release Date : 2004-04-07
  • Total pages : 408
  • ISBN : 9780081000984
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Summary : A practical, easily accessible guide for bench-top chemists, thisbook focuses on accurately applying computational chemistrytechniques to everyday chemistry problems. Provides nonmathematical explanations of advanced topics incomputational chemistry. Focuses on when and how to apply different computationaltechniques. Addresses computational chemistry connections to biochemicalsystems and polymers. Provides a prioritized list of methods ...

A Practical Guide To Cancer Systems Biology

A Practical Guide To Cancer Systems Biology
  • Author : Juan Hsueh-fen,Huang Hsuan-cheng
  • Publisher : World Scientific
  • Release Date : 2017-11-29
  • Total pages : 152
  • ISBN : 9780081000984
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Summary : Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis ...

A Practical Guide to Pharmacological Biotechnology

A Practical Guide to Pharmacological Biotechnology
  • Author : Jayanta Kumar Patra,Swagat Kumar Das,Gitishree Das,Hrudayanath Thatoi
  • Publisher : Springer
  • Release Date : 2019-03-25
  • Total pages : 142
  • ISBN : 9780081000984
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Summary : Pharmacological biotechnology is applied to and used to study drug development, working mechanisms, diagnosis, and therapies. This textbook covers the whole range of experiments related to pharmacology. It also contains basic laboratory safety guidelines along with the basic calculations and formulas used in a laboratory. Each chapter starts with an ...

A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery

A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery
  • Author : Taosheng Chen
  • Publisher : CRC Press
  • Release Date : 2009-12-21
  • Total pages : 291
  • ISBN : 9780081000984
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Summary : The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P...

Computational Drug Design

Computational Drug Design
  • Author : D. C. Young
  • Publisher : John Wiley & Sons
  • Release Date : 2009-01-28
  • Total pages : 344
  • ISBN : 9780081000984
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Summary : Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools ...

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis
  • Author : Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza
  • Publisher : Springer Nature
  • Release Date : 2019-11-09
  • Total pages : 560
  • ISBN : 9780081000984
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Summary : This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved ...

A Comprehensive Guide to Toxicology in Preclinical Drug Development

A Comprehensive Guide to Toxicology in Preclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2012-11-16
  • Total pages : 885
  • ISBN : 9780081000984
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Summary : A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide ...

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2016-11-03
  • Total pages : 986
  • ISBN : 9780081000984
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Summary : A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem ...

A Practical Guide to Scientific Data Analysis

A Practical Guide to Scientific Data Analysis
  • Author : David J. Livingstone
  • Publisher : John Wiley & Sons
  • Release Date : 2009-12-10
  • Total pages : 358
  • ISBN : 9780081000984
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Summary : Inspired by the author's need for practical guidance in the processes of data analysis, A Practical Guide to Scientific Data Analysis has been written as a statistical companion for the working scientist. This handbook of data analysis with worked examples focuses on the application of mathematical and statistical techniques and ...

Fragment Based Drug Discovery

Fragment Based Drug Discovery
  • Author : Edward R. Zartler,Michael Shapiro
  • Publisher : John Wiley & Sons
  • Release Date : 2008-11-20
  • Total pages : 296
  • ISBN : 9780081000984
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Summary : Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who ...

A Practical Guide to Combinatorial Chemistry

A Practical Guide to Combinatorial Chemistry
  • Author : Anthony W. Czarnik,Sheila Hobbs Dewitt
  • Publisher : Amer Chemical Society
  • Release Date : 1997
  • Total pages : 450
  • ISBN : 9780081000984
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Summary : Combinatorial chemistry is the ability to simultaneously synthesize vast numbers of diverse compounds. Its techniques have revolutionized the drug discovery process, and are widely used throughout the biotechnology community. Aimed at a wide audience, this text is a down-to-earth introductionto small molecule combinatorial chemistry. It uses a tutorial approach to ...