Description : M. Gabriel Khan, MD, concisely assembles in a reader friendly format all the clinically useful information that an internist needs in both his daily rounds and abusy office practice to find correct clinical diagnoses and choose optimal pharmacologic therapies for their patients. Highlights include a simplified method for recognition of, and a practical therapeutic approach to, arrhythmias, as well as a more logical approach to drug management of hypertension than that given by the Joint National Committee, instructive algorithms that simplify the diagnosis and treatment of syncope, and extensive diagnostic information on hypertrophic cardiomyopathy. A large number of illustrative electrocardiograms that help to clarify the most often misinterpreted of all cardiologic tests and extensive discussions of practical cardiovascular pharmacology complete this magisterial survey.
Description : Covers accessing and distilling PDF files; converting MicrosoftOffice documents; capturing paper documents and Web pages;printing, annotating, editing and securing PDF files; extractingtext and graphics; cataloging and distributing PDF files; creatinginteractive forms; and building multimedia presentations. Readers can convert any document to this universal file format,preserving all the fonts, formatting, graphics, and color of thesource document regardless of the application and platform used tocreate it. PDF files can be published and distributed anywhere: in print,attached to e-mail, on corporate servers, posted on Web sites, oron CD-ROM Adobe PDF is the emerging workflow standard in the $400 billionpublishing industry and plays a key role in financial services,regulated industries, and government, with more than 155 agenciesworldwide sharing Adobe PDF files.
Description : What happens when advances in technology allow many things to be produced for more or less nothing? And what happens when those things are then made available to the consumer for free? In his groundbreaking new book, The Long Tail author Chris Anderson considers a brave new world where the old economic certainties are being undermined by a growing flood of free goods - newspapers, DVDs, T shirts, phones, even holiday flights. He explains why this has become possible - why new technologies, particularly the Internet, have caused production and distribution costs in many sectors to plummet to an extent unthinkable even a decade ago. He shows how the flexibility provided by the online world allows producers to trade ever more creatively, offering items for free to make real or perceived gains elsewhere. He pinpoints the winners and the losers in the Free universe. And he demonstrates the ways in which, as an increasing number of things become available for free, our decisions to make use of them will be determined by two resources far more valuable than money: the popular reputation of what is on offer and the time we have available for it. In the future, he argues, when we talk of the 'money economy' we will talk of the 'reputation economy' and the 'time economy' in the same breath, and our world will never be the same again.
Description : If you're frustrated with your lack of success finding a publisher...if you've looked into companies that will publish your book for you and been appalled at what they charge...if you wish you better understood what the new printing and ebook technologies meant in terms of your options, then this little book can help. Author Diane Lau (aka Diana Laurence) gives the whole scoop on how she published her titles through her own small publishing house, and tells how you can too. "Do-It-YourSelf-Publishing" is a step-by-step blueprint through the entire process, to help you decide if this approach is right for you, and guide you to valuable resources that will enable you to become your own publisher. From estimating your costs to finding out the skills you need and how to acquire them, you'll learn how a previously published author found a more enjoyable and profitable way to sell her books: by publishing herself.
Description : An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.
Description : Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.
Description : Practicing specialists in pathology, laboratory medicine, and obstetrics comprehensively summarize the latest scientific findings and their experiences in the use and interpretation of laboratory testing in patients who are pregnant or experiencing recurrent pregnancy loss. Topics of interest include the effects of normal physiological changes on test results, test selection for diagnosis, changes in reference ranges, monitoring the pregnant patient, new technologies, and the limitations of laboratory testing. The authors not only clearly explain currently used test methods and technologies for the nontechnical reader, but also provide comprehensive details for laboratory professionals. The comprehensive appendix that compiles published normal reference ranges by first, second, and third trimester consttitutes an excellent resource for professionals caring for pregnant women.
Description : A novel about love. Raw important love. Small, beautiful love. And what happens when the person you love cannot be yours… Perfect for fans of Rowan Coleman, Jane Green and David Nicholls. Kate and Becca are cousins and best friends. They have grown up together and shared all the most important milestones in their lives: childhood birthday parties, eighteenth birthdays, and now a wedding day as they each marry their childhood sweethearts, Charlie and Julian. Kate has always loved Charlie - they were meant to be. Then she discovers that life never turns out quite how you expect it to. And love doesn't always follow the journey it should. But best friends are forever, and true love will find a way, won't it…? Praise for These Days of Ours: ‘Gloriously and irresistibly romantic, I devoured These Days of Ours in a single sitting. There's not just one compelling love story here but two; the twenty-year love story of Kate and Charlie, and also the lifelong friendship between Kate and her cousin Becca. It's like One Day with all the additional trials and tribulations of female friendship’ Hannah Beckerman 'Heart-felt, heart-breaking but ultimately heart-warming. Juliet Ashton has written the romance of the year' Chrissie Manby ‘Juliet Ashton dramatises the landmarks of a young woman’s life with an irresistible lightness of touch. Warm, witty and surprising’ Louise Candlish ‘A delicious story of love and loss that had me utterly entranced. It made me laugh and it made me weep, but most of all it made me relish the warmth of the human heart’ Kate Furnivall Praise for Juliet Ashton: 'Funny, original and wise' Katie Fforde 'Cecelia Ahern fans will love this poignant yet witty romance' Sunday Mirror 'You'll laugh and cry your way through this original and touching love story' Closer